A5044847879- Pregnancy and preeclampsia studies
- Maternal and fetal healthcare
- Birth, Development, and Health
- Assisted Reproductive Technology and Twin Pregnancy
- Neonatal Respiratory Health Research
- Prenatal Screening and Diagnostics
- Trauma and Emergency Care Studies
- Gestational Diabetes Research and Management
- Maternal and Perinatal Health Interventions
- Neonatal and fetal brain pathology
- Hemophilia Treatment and Research
- Uterine Myomas and Treatments
- Pregnancy-related medical research
- Cardiovascular Issues in Pregnancy
- Ectopic Pregnancy Diagnosis and Management
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Cardiac Health and Mental Health
- Child and Adolescent Health
- Iron Metabolism and Disorders
- Breastfeeding Practices and Influences
- Endometrial and Cervical Cancer Treatments
- Reproductive Health and Technologies
- Pituitary Gland Disorders and Treatments
- Tumors and Oncological Cases
- Reproductive System and Pregnancy
Klinik für Frauenheilkunde
2019-2024
Universität Hamburg
2021-2024
University Medical Center Hamburg-Eppendorf
2021-2024
University Hospital of Bern
2014-2024
University of Bern
2018-2024
Universitäts Frauenklinik
2020
University Hospital of Zurich
2010
Background: Despite a range of available treatments, there is remaining unmet need for patients with severe post-partum hemorrhage (sPPH). Objective: This manuscript evaluated efficacy and safety recombinant activated factor VIIa (rFVIIa) in sPPH management. Methods: An open-label, multi-center, randomized controlled trial (RCT; NCT00370877) four observational studies (OS; OS-1 [NCT04723979], OS-2, OS-3 OS-4) were analyzed regarding (need subsequent invasive procedures, including uterine...
Abstract Purpose Peripartum hemorrhage (PPH) remains one of the main causes maternal mortality worldwide. Treatment includes administration packed red blood cells (RBC) in severe cases and patient management (PBM) may reduce it significantly. In our study, we wanted to retrospectively assess cell PPH evaluate impact PBM Switzerland. Methods Using data from Swiss obstetric hospital registry (Arbeitsgemeinschaft Schweizer Frauenkliniken, ASF), included patients with deliveries 1998 2016. We...
Abstract Hypertensive disorders of pregnancy (HDP) contribute substantially to perinatal morbidity and mortality. Epigenetic changes point towards cardio-metabolic dysregulation for these vascular disorders. In early pregnancy, epigenetic using cell free DNA (cfDNA) are largely unexplored. We aimed investigate in HDP between 11 14 weeks gestation by analysis cfDNA methylation profiles patients with hypertensive identified without chronic hypertension but subsequent development preeclampsia...
Postpartum hemorrhage (PPH) is a leading cause of maternal morbidity and mortality. Routine treatment PPH includes uterotonics, tranexamic acid, curettage, uterine (balloon) tamponade, compression sutures, artery ligation, and, if available, transcatheter arterial embolization (TAE). In cases severe refractory to standard medical surgical management, hysterectomy usually the ultima ratio, equally associated with higher rate complications. addition, this sudden loss fertility, especially in...
OBJECTIVE Late preterm infants (born between 34 0/7 and 36 6/7 weeks of gestation) have been shown to a higher morbidity mortality than term infants. Furthermore, twins, both preterm, neonatal singletons. The aim our study was examine if late twins consequently twice the when risk factors prematurity multiple pregnancy are present. STUDY DESIGN A retrospective single-centre conducted compare outcome singletons born gestation as well with gestational age from 37 41 weeks. Primary length...
Postpartum hemorrhage (PPH) remains a major cause of maternal morbidity and mortality. While PPH treatment guidelines exist, data on their effect reduction in red blood cell (RBC) transfusions use hemostatic products are scarce. Continuous evaluation management is important to assess potential pitfalls incorporate new options. We retrospectively compared administration RBC before after international guideline implementation. The primary endpoint was for PPH. Secondary endpoints were...
Background: Despite a range of available treatments, it is still sometimes challenging to treat patients with severe post-partum hemorrhage (sPPH). Objective: This study evaluated the efficacy and safety recombinant activated factor VIIa (rFVIIa) in sPPH management. Methods: An open-label, multi-center, randomized controlled trial (RCT; NCT00370877) four observational studies (OS; OS-1 (NCT04723979), OS-2, OS-3, OS-4) were analyzed regarding (need for subsequent invasive procedures,...
Abstract Aim Breastfeeding has numerous advantages. Our aim was to investigate whether breastfeeding initiation and duration in women with pregnancies conceived through vitro fertilisation differ from spontaneously pregnancies. Methods This is a comparative cross‐sectional study about behaviour performed at the Bern University Hospital including mothers of singletons by (n = 198) or without gonadotropin stimulation between 2010 2016 (in group). They were compared population‐based control...
Objectives: Management of severe postpartum hemorrhage (PPH) includes transcatheter pelvic arterial embolization (TAE). Data regarding subsequent fertility and obstetrical outcomes is limited, as most derive from TAE in uterine fibroma. The purpose our study was to evaluate the long-term patients undergoing TAE, particularly concerning following pregnancies. Material methods: We included 28 who underwent for PPH at institution between 2009 2018 a retrospective cohort study. were assessed by...
<b><i>Introduction:</i></b> To determine the accuracy of estimated fetal weight (EFW) at limit viability in a delivery room setting and its impact on prediction neonatal outcome. <b><i>Material Methods:</i></b> In this retrospective, single-center cohort study we included patients with preterm birth between 23<sup>0</sup>/<sub>7</sub> 26<sup>0</sup>/<sub>7</sub> weeks gestation. Neonates were...
Abstract The aim of our study was to compare maternal, chorionicity and neonatal complications in monochorionic (MC) twins between spontaneously conceived (SC) assisted reproductive technologies (ART) pregnancies. This a retrospective cohort January 2010 December 2019 at tertiary referral University center. All consecutive pregnancies with MC that delivered hospital were included. Maternal, recorded compared SC ART 393 included for final analysis, including 353 (89.8%) 40 (10.2%) after ART....
Iron deficiency (ID) and iron anemia (IDA) are very common in women during their reproductive life, but often these conditions remain unrecognized left untreated, particularly low/ middle income countries (LMICs). Heavy menstrual bleeding (HMB) pregnancy associated with ID/IDA, influencing health the physical social lives of individuals. Cross discipline expertise has considered evidence presented here pathophysiological mechanisms, symptoms, diagnostic criteria therapeutic approaches to...
Zielsetzung: Maternale kardiovaskuläre Fehlanpassungen können zu einer gestörten Plazentation mit oft untergewichtiger Plazenta und entsprechenden Schwangerschaftskomplikationen (SSK) führen. Bei Frauen vorbestehenden oder kongenitalen Herzerkrankungen (HEK) scheint die Inzidenz dieser Komplikationen erhöht sein. Ziel der retrospektiven Studie war es, Verteilung Plazentagewichte in diesem Kollektiv untersuchen.
Zielsetzung: Angeborene Herzfehler (AHF) sind die häufigsten angeborenen Malformationen weltweit. Hierbei kann eine veränderte feto-plazentare Hämodynamik zur gestörten Plazentation führen und das fetale Wachstum beeinträchtigen. Ziel dieser retrospektiven Studie war es, Korrelation zwischen Plazenta- Geburtsgewicht bei Kindern mit AHF zu untersuchen.
We previously showed that the umbilical artery (UA) time-averaged maximum velocity (TAMXV) measured within first trimester seems to be a "Marker" of utero-placental development as it correlated with uterine pulsatility index. Aim our study was construct reference range for TAMXV trimester.
Objective: To identify possible confounding factors that have a negative impact on the accuracy of fetal weight estimation (FWE) in very low gestational age infants and to determine FWE neonatal outcome.
Einleitung C-reaktives Protein (CRP) ist ein sogenanntes Akut-Phase Protein. Bei Entzündungen oder Gewebeverletzungen steigt es schnell und signifikant im Blutserum an. Gesunde Schwangerschaften sind mit einem leichtgradigen Entzündungszustand assoziiert, jedoch hinsichtlich der Rolle von CRP in Schwangerschaft, insbesondere Kontext hypertensiven Schwangerschaftserkrankungen wie Präeklampsie (PE) wenig bekannt [1]. Studien haben gezeigt, dass PE eine Folge einer Überspitzung maternalen...