A5080878091- Pancreatic and Hepatic Oncology Research
- RNA modifications and cancer
- Eosinophilic Esophagitis
- Asthma and respiratory diseases
- Renal cell carcinoma treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- RNA Research and Splicing
- IL-33, ST2, and ILC Pathways
- Gastrointestinal Tumor Research and Treatment
- Renal and related cancers
- Cancer Immunotherapy and Biomarkers
- Gallbladder and Bile Duct Disorders
- Cancer-related gene regulation
- PI3K/AKT/mTOR signaling in cancer
- Advanced Computing and Algorithms
- MRI in cancer diagnosis
- Radiomics and Machine Learning in Medical Imaging
- Peptidase Inhibition and Analysis
- Gastrointestinal disorders and treatments
- Central Venous Catheters and Hemodialysis
- Hedgehog Signaling Pathway Studies
- Cancer-related molecular mechanisms research
- RNA and protein synthesis mechanisms
- Immune Cell Function and Interaction
- Pediatric health and respiratory diseases
State Key Laboratory of Oncogene and Related Genes
2022-2024
Shanghai Jiao Tong University
2022-2024
Ningbo Medical Center Lihuili Hospital
2016-2023
Eye & ENT Hospital of Fudan University
2021-2022
The People's Hospital of Guangxi Zhuang Autonomous Region
2017-2018
Guangxi University of Chinese Medicine
2016
Colonic mucosal barrier dysfunction is one of the major causes inflammatory bowel disease (IBD). However, mechanisms underlying are poorly understood. N6-methyladenosine (m6A) mRNA modification an important modulator epitranscriptional regulation gene expression, participating in multiple physiological and pathological processes. function m6A colonic epithelial cells stem unknown. Here, we show that essential for maintaining homeostatic self-renewal cells. Specific deletion methyltransferase...
Abstract RNA-binding proteins (RBPs) can recognize thousands of RNAs that help to maintain cell homeostasis, and RBP dysfunction is frequently observed in various cancers. However, whether specific RBPs are involved tumor immune evasion by regulating programmed death ligand-1 (PD-L1) unclear. Here, we perform targeted CRISPR/Cas9 screening identify density regulated re-initiation release factor (DENR) as a PD-L1 regulator. DENR-depleted cancer cells exhibit reduced expression vitro vivo....
Abstract Macrophage hyperactivation is a hallmark of inflammatory diseases, yet the role alternative polyadenylation (APA) mRNAs in regulating innate immunity remains unclear. In this study, we focused on 3’UTR-APA and demonstrated that Nudt21, crucial RNA-binding component machinery, significantly upregulated various conditions. By utilizing myeloid-specific Nudt21-deficient mice, revealed protective effect Nudt21 depletion against colitis severe hyperinflammation, primarily through...
The aim of the present study was to investigate antitumor properties N-(N-[3,5-difluorophenacetyl]-1-alanyl)-S-phenylglycine t-butyl ester (DAPT) against hepatocellular carcinoma (HCC), as well underlying mechanism.Immunohistochemistry and quantitative reverse transcription polymerase chain reaction (qRT-PCR) assay were used determine expression Notch1 in HCC tissues. 3 cell lines evaluated by qRT-PCR Western blot. proliferation ability cells detected...
To establish the murine models of local allergic rhinitis (LAR) and (AR) by using ovalbumin (OVA), to investigate relationship between them.Thirty BALB/c mice were divided into 5 groups, (1) nasally sensitized group (group A1) that was challenged with OVA a 10 d procedure, (2) control A1 phosphate-buffered saline (PBS), (3) A2) 25 (4)the A2 PBS, (5) intraperitoneally B) .The numbers sneezing after final challenge counted, serum OVA-specific immunoglobulin E (OVA-sIgE), interleukin (IL) -4,...
Background: In pancreatic cancer surgery, tumor violation of blood vessels is often considered a contraindication to especially laparoscopic surgery. We have completed 17 cases major venous repair or reconstruction during and we believe that this surgical method may be safe feasible based on the skilled techniques. Materials Methods: Between January 2014 March 2022, prospective cohort patients underwent in our department. Among them, 15 pancreaticoduodenectomy, 1 case distal pancreatectomy,...
Background: Since the first laparoscopic pancreaticoduodenectomy (LPD) was performed in 1994, feasibility and safety of total (TLPD) have been confirmed by several single-institutional series. However, a standard approach is still lacking. Here, we present our initial experience TLPD.Methods: We retrospectively reviewed 27 consecutive patients who had undergone TLPD one operator between January 2013 August 2016 at Ningbo Medical Centre Lihuili Hospital.Results: A LPD were carried out,...
MicroRNA (miRNA/miR)-3677 has been indicated to be negatively associated with the survival of patients hepatocellular carcinoma (HCC) based on The Cancer Genome Atlas database. However, as a novel miRNA, role miR-3677-5p in HCC remained elucidated. In present study, expression was assessed tissues and cell lines using reverse transcription-quantitative PCR. Survival analysis performed Kaplan-Meier curves. Furthermore, prognostic significance evaluated Cox regression analysis. effects...
Background: Since the first laparoscopic pancreaticoduodenectomy (LPD) was performed in 1994, feasibility and safety of total (TLPD) have been confirmed by several single-institutional series. However, a standard approach is still lacking. Here, we present our initial experience TLPD. Methods: We retrospectively reviewed 27 consecutive patients who had undergone TLPD one operator between January 2013 August 2016 at Ningbo Medical Centre Lihuili Hospital. Results: A LPD were carried out,...
Objective To compare the safety and efficacy of retrograde antegrade techniques in laparoscopic left hemihepatectomy. Methods Of 65 patients who underwent hemihepatectomy between January 2016 to June 2018 at Ningbo Li Huili Hospital Medical Center, was carried out 31 patients, 34 patients. The perioperative data, duration operation, intraoperative blood loss, postoperative complications (including major bleeding, abdominal abscess bile leakage), post-operative hospital stay were...
Abstract Background In pancreatic cancer surgery, tumor violation of blood vessels is often considered a contraindication especially laparoscopic surgery. We had completed 17 cases major venous repair or reconstruction during and we that this surgical method was safe feasible based on the skilled techniques. Methods Between January 2014 March 2022. A prospective cohort patients underwent reconstruction. Among them, 15 pancreaticoduodenectomy (LPD), 1 case distal pancreatectomy (LDP) central...