A5101844231- Advanced MRI Techniques and Applications
- Atomic and Subatomic Physics Research
- Cardiac Imaging and Diagnostics
- Healthcare professionals’ stress and burnout
- Acute Lymphoblastic Leukemia research
- Influenza Virus Research Studies
- Medical and Health Sciences Research
- Cancer therapeutics and mechanisms
- Diabetic Foot Ulcer Assessment and Management
- Functional Brain Connectivity Studies
- Obstructive Sleep Apnea Research
- Bioinformatics and Genomic Networks
- Soft Robotics and Applications
- Healthcare cost, quality, practices
- Foot and Ankle Surgery
- Single-cell and spatial transcriptomics
- Cardiac, Anesthesia and Surgical Outcomes
- Traumatic Ocular and Foreign Body Injuries
- Intravenous Infusion Technology and Safety
- Advanced Proteomics Techniques and Applications
- UAV Applications and Optimization
- NMR spectroscopy and applications
- Posttraumatic Stress Disorder Research
- Teaching and Learning Programming
- Respiratory viral infections research
Kansas City University
2021
University of California, San Diego
2009-2020
Rush University Medical Center
2020
UCSF Benioff Children's Hospital
2019
University of California, San Francisco
2013-2019
University of Georgia
2015-2018
UCSF Helen Diller Family Comprehensive Cancer Center
2016
Center for Theoretical Biological Physics
2009
University of Hawaiʻi at Mānoa
2009
University of Hawaii System
2009
A comprehensive knowledge of proteomic states is essential for understanding biological systems. Using mass spectrometry, we mapped an atlas developing maize seed proteotypes comprising 14,165 proteins and 18,405 phosphopeptides (from 4,511 proteins), quantified across eight tissues. We found that many the most abundant are not associated with detectable levels their mRNAs, provide evidence three potential explanations: transport between tissues; diurnal, out-of-phase accumulation mRNAs...
Abstract Acute lymphoblastic leukemia (ALL) is the most common cancer in children. The highest rates of treatment failure occur specific genetic subsets ALL, including hypodiploid B-cell ALL (B-ALL), for which effective alternative therapies to current intensive chemotherapy treatments have yet be developed. Here, we integrated biochemical and genomic profiling with functional drug assays select agents therapeutic potential against B-ALL. ABT-199, a selective Bcl-2 inhibitor, was reducing...
Hemagglutinins (HA's) from duck, swine, and human influenza viruses have previously been shown to prefer avian glycan receptor analogues with distinct topological profiles, pentasaccharides LSTa (α-2,3 linkage) LSTc (α-2,6 linkage), in comparative molecular dynamics studies. On the basis of detailed analyses dynamic motions binding domains (RBDs) interaction energy profiles individual residues, we identified ∼30 residue positions RBD that present analogues. Glycan constrained conformational...
Unmanned aerial vehicle (UAV) systems are experiencing a period of rapid growth as potential for industrial and commercial applications arising. Conventional UAV technologies focus on outdoor large area navigation, utilising global positioning system, which has proven to be less effective in enclosed environments. The authors aim develop an indoor navigation specifically require custom sensing aid pilot navigation. A array, featuring ultrasonic transceivers, was developed localise drone...
Microscopic medical robots capable of translating in a bloodstream or similar liquid represent new type therapeutic technology for surgical interventions. This study aims to characterize MRI compliant method propulsion swimming using the magnetohydrodynamic effect (MHD). An MHD drive is employing only electromagnetic elements, without need moving mechanical parts. By utilizing voltages induced within magnetic field, opportunity propel device and provide imaging simultaneously presented. We...
<h3>PURPOSE</h3> We sought to compare and contrast patterns of change toward patient-centered medical homes (PCMHs) in 5 New Orleans primary care safety net clinics the aftermath Hurricane Katrina. assessed general direction practice discover possible reasons for differences change, identify impediments change. <h3>METHODS</h3> Data collection consisted semiannual telephone interviews with clinic leadership over 2.5 years supplemented by administrative audits. used standard survey indexes...
Background: Blood volume assessment is a valuable clinical metric, which can diagnostically be used to assess tissue health, monitor patient rehabilitation, and track the progression of wound healing. Currently there exists several methods flow (MRI, US), but are either limited in cost or portability, may require injection contrast agents. Magnetohydrodynamic voltages (VMHD) induced through blood interactions with an external magnetic field, have been successfully measured using modified ECG...
Higher risk patient populations require continuous physiological monitoring and, in some cases, connected life-support systems, during magnetic resonance imaging examinations. While recently there has been a shift toward wireless technology, of the devices are still to outside using cabling that could interfere with imaging’s radio frequency scanning, resulting excessive heating. We developed passive method for suppression on may assist making these compatible. A barrel-shaped strongly...
"Sustainable futures: propelling innovative ecosystems" was the theme intended for Ninth Annual National Academy of Inventors Meeting. With meeting cancelled, content conference is being distributed online and in print format. Indeed, rather than shifting conference's theme, COVID-19 pandemic has required us to examine ecosystems a new context that likely would not have been fully explored otherwise. Makerspaces, an important part innovation ecosystem, rose alongside maker movement as...
Blood flow in a clinical metric with variety of uses, namely, the diagnosing and longitudinal monitoring patients or at risk cardiovascular disease. Currently, blood is able to be quantified through techniques including Doppler ultrasound (DUS), computer tomography (CT), magnetic resonance imaging (MRI). The majority these methods require an expensive, immobile device (MRI CT) skilled technician operate (DUS, MRI, CT), thus are accessible very few need technology.One diseases mainly...
Poor sleep quality is associated with metabolic dysregulation and impaired healing. The purpose of the current study was to quantify prevalence poor in patients atraumatic foot ankle (F&A) conditions determine whether surgical treatment improvement.Patients scheduled for management F&A were enrolled by 4 fellowship-trained orthopaedic surgeons between May 2018 April 2019. Patients completed Pittsburgh Sleep Quality Index (PSQI) pre- postoperatively. PSQI ranges from 0 21, a score ≥5...
The electrocardiogram (ECG) is commonly utilized for patient monitoring during magnetic resonance imaging (MRI) despite known magnetohydrodynamic voltage (VMHD) overlays, which often eclipse the true sinus rhythm and render signal to be non-diagnostic. This can complicate MRI gating at-risk monitoring, causing alternative low-fidelity signals become preferred. We aimed develop a method of isolating from VMHD in order enable use high-fidelity ECGs procedures. Twelve-lead were acquired two...
<div>Abstract<p><b>Purpose:</b> p27 localization and expression has prognostic predictive value in cancer. Little is known regarding patterns of renal cell carcinoma (RCC) or how participates disease progression response to therapy.</p><p><b>Experimental Design:</b> RCC-derived lines, primary tumors, normal epithelial cells were analyzed for expression, phosphorylation (T157 the NLS), subcellular localization. lines treated with...
The magnetohydrodynamic (MHD) effect is observed in flowing electrolytic fluids and their interactions with magnetic fields. field (B0), when perpendicular the fluid flow (μ), causes shift of charged particles to across length vessel (L) normal plane B0 flow, creating a voltage (VMHD) observable through potential measurements (Eqn. 1)[1].(1)VMHD=∫0Lu⇀×B0⇀·dL⇀In medical field, this phenomenon commonly encountered inside human body an MRI machine (Fig. 1). appears most prominently aortic arch...
Category: Prescription Practices Introduction/Purpose: Opioid abuse has recently reached the conscience of US healthcare system and news cycle. This epidemic is in part propagated by surgeon over-prescription for common procedures. The purpose this study to examine postoperative opioid use following outpatient foot ankle surgery order potentially guide prescription patterns narcotics. Methods: Patients undergoing or surgery, performed one four fellowship-trained orthopedic surgeons from a...
Abstract Understanding the complexity of cell interactions in tumor microenvironment (TME) requires ability to distinguish each type, and is a prerequisite personalized cancer treatments. Here, we use fully integrated system for single RNA sequencing, simultaneously profile transcriptome, surface proteins immune repertoire cells from primary colorectal (CRC), non-small lung (NSCLC), mucosa-associated lymphoid tissue (MALT) lymphoma. Each varied type proportion its cellular components,...
Patients are often made weightbearing as tolerated (WBAT) in a controlled ankle motion (CAM) boot for the management of various foot and conditions. The CAM causes leg length discrepancy (LLD) between booted (longer) contralateral (shorter) lower extremities. This can potentially cause balance problems, undue strain on joints, discomfort patients. We hypothesized that length-evening orthotic placed plantar aspect shoe improves among patients who WBAT boot.Patients were randomized to either...