A5040484891- Phytochemicals and Antioxidant Activities
- Phytochemistry and Biological Activities
- Essential Oils and Antimicrobial Activity
- Biochemical and Structural Characterization
- Natural product bioactivities and synthesis
- Medicinal Plant Research
- Antioxidant Activity and Oxidative Stress
- Medicinal plant effects and applications
- Bee Products Chemical Analysis
- Pharmacological Effects of Natural Compounds
- Traditional Chinese Medicine Analysis
- Garlic and Onion Studies
- Alkaloids: synthesis and pharmacology
- Streptococcal Infections and Treatments
- Food Quality and Safety Studies
- Phytochemical Studies and Bioactivities
- Psoriasis: Treatment and Pathogenesis
- Microbial Metabolism and Applications
- Botanical Research and Chemistry
- Sirtuins and Resveratrol in Medicine
- Berberine and alkaloids research
- Glycosylation and Glycoproteins Research
- Spectroscopy and Chemometric Analyses
- Fermentation and Sensory Analysis
- Plant Toxicity and Pharmacological Properties
Iuliu Hațieganu University of Medicine and Pharmacy
2012-2024
Hypoxia is a critical pathological factor in variety of retinal diseases, including age-related macular degeneration. It upregulates angiogenic growth factors and promotes neovascularization. changes the cellular redox state activates class III histone deacetylase sirtuin1 (SIRT1). Activated SIRT1 signals hypoxia inducible (HIF)-2α, which transactivates vascular endothelial (VEGF) erythropoietin. In this study, we investigated role induced choroidal neovascularization relation to...
The aim of this paper was to evaluate the antioxidant and antimicrobial activities polyphenolic content Schisandra chinensis (Turcz.) Baill. leaves fruits. are an important source flavonoids (35.10 ± 1.23 mg RE/g plant material). Qualitative quantitative analyses compounds were achieved using a HPLC-UV-MS method. main flavonoid from isoquercitrin (2486.18 5.72 μg/g material), followed by quercitrin (1645.14 2.12 Regarding fruit composition, dominant compound there rutin (13.02 0.21 but...
Several Ajuga species are used in Romanian folk medicine for their antioxidant, antimicrobial and anti-inflammatory properties, to treat pain, fever or arthritis. Still, the active compounds responsible these effects mechanism of action scarcely known. This research was designed investigate phytochemical profile (e.g. iridoids, polyphenolic compounds, phytosterols), as well biological potential (antioxidant, antibacterial, antifungal, properties) two selected collected from different regions...
In the Romanian folk medicine, aerial parts of Ajuga laxmanii ("nobleman's beard", – "barba boierului" or "avrămească" "creștinească") is traditionally used as a galactogogue and anti-inflammatory agent. The present study was aimed to evaluate chemical composition (polyphenols, iridoids, phytosterols), antioxidant, antimicrobial in vivo activity different extracts A. parts. major identified bioactive compounds were rutin, 8-O-acetylharpagide β-sitosterol. antioxidant laxmannii evaluated...
Solidago species are often used in traditional medicine as anti-inflammatory, diuretic, wound-healing and antimicrobial agents. Still, the bioactive compounds biological activities of some have not been studied. The present work aimed to investigate polyphenolic profile properties graminifolia L. Salisb., a poorly explored medicinal plant. hydroalcoholic extracts from aerial parts were evaluated for total phenolic content (TPC), flavonoid (TFC) investigated by HPLC-MS. antioxidant potential...
The use of antioxidants and antibacterials in food industry has become increasingly necessary to ensure the high quality food. Grape pomace is main by-product winemaking that concentrates bioactive metabolites with more studied antioxidant activity possible antibacterial activity. grape contains fragmented skin, broken cells, pulp remains, stalks seeds amount phenolic compounds due their poor extraction during process. Anthocyanins, catechins, flavonol glycosides, acids, alcohols stilbenes...
Epilobium species are used in Romanian folk medicine as tinctures, tea, or tablets for ameliorating the symptoms of benign prostate hyperplasia (BPH), but scientific-based evidence is scarce this other endemic plants same genus. Therefore, aims research were to evaluate phytochemical profile five (E. hirsutum L., E. parviflorum Schreb., palustre L. dodonaei Vill., and angustifolium L.) assess their vitro biological activity. For enhanced recovery polyphenols, a D-optimal experimental plan...
Five Allium species (Allium obliquum L., A. senescens L. subsp. montanum (Fries) Holub, schoenoprasum schoenoprasum, fistulosum and ursinum L.) were analysed in order to determine the presence of 19 polyphenolic compounds through an HPLC method coupled with UV mass spectrometry detection. The pattern phenol carboxylic acids indicates p-coumaric ferulic all species. Isoquercitrin was found obliquum, fistulosum, rutin whereas quercitrin only so they represent potential taxonomic markers that...
The present research investigated the in vivo anti-inflammatory and cardioprotective activities, as well antioxidant potential of Taraxacum officinale tincture (TOT), relation to polyphenolic composition. Chromatographic spectrophotometric techniques were used determine profile TOT activity was preliminarily assessed vitro by DPPH• FRAP methods. activities studied rat turpentine-induced inflammation isoprenaline-induced myocardial infarction (MI) models. main compound identified cichoric...
The purpose of this work was to evaluate chemical constituents, antioxidant and antimicrobial activities Artabotrys hildebrandtii, an endemic medicinal plant from Madagascar. Ethanol extracts the leaves stem bark were tested DPPH free radical scavenging, using butylated hydroxytoluene quercetin as standard antioxidants. An high-performance liquid chromatography/mass spectrometry method developed investigate presence phenolic compounds in studied samples; gentisic acid, chlorogenic...
Backround:Ajuga species have been used in traditional medicine for their diuretic, anti-inflammatory, wound-healing, and hepatoprotective properties. Purpose: The phytochemical profile anticancer potential of three Ajuga sp. (A. genevensis, A. chamaepitys, laxmannii) from Romania was investigated. Materials Methods: phytochemicals were extracted the aerial parts by using different solvents methods. hydroalcoholic extracts examined total phenolic, flavonoid iridoid contents, HPLC/MS to...
Epilobium hirsutum L., commonly known as hairy willowherb, is a perennial herbaceous plant native to Europe and Asia. In Romania, the genus includes 17 species that are used in folk medicine for various purposes. This study aimed investigate anti-inflammatory antitumor potential of optimized extract (EH) animal models. The first investigated properties EH model was carrageenan-induced paw inflammation. Wistar rats were divided into three groups: negative control, positive control treated...
Nowadays, there is an increasing interest in the study of medicinal and aromatic plants, due to their therapeutic properties that correlate with presence different active compounds. Agastache species (sp.) are plants belong Lamiaceae family, originating from North America East Asia. The present aimed evaluate composition essential oils (EOs) obtained Romanian cultivated sp. investigate antibacterial cytotoxic activities. gas chromatography-mass spectrometry (GC–MS) screening revealed...
Abstract Saponins from defatted root-extract of Securidaca longipedunculata were systematically entrapped in emulsion monolayer-barrier and finally recovered pure form through demulsification. First, their molecules dispersed water to engineer a monomolecular film architecture, via self-assembly. Emulsifying with ethyl-ether resulted swollen micelles engendered phase-inversion phase-separation, by disrupting the thermodynamic equilibrium. As positive outcome, Winsor II system was obtained,...
Solidago virgaurea L. is a perennial plant used in European traditional medicine as diuretic or remedy for inflammatory conditions of the urinary tract but also gout, especially Balkans. The present study was focused on preclinical, vivo evaluation antihyperuricemic, anti-inflammatory, and antihypertensive effects dry extract from S. (ESV). Colorimetric HPLC–MS techniques were to identify main chemical constituents ESV. Antihyperuricemic effect ESV assessed rat model hyperuricemia induced by...