A5040862875- HIV/AIDS Research and Interventions
- HIV, Drug Use, Sexual Risk
- Adolescent Sexual and Reproductive Health
- Reproductive tract infections research
- Reproductive Health and Contraception
- Sex work and related issues
- Renal Diseases and Glomerulopathies
- Influenza Virus Research Studies
- HIV Research and Treatment
- HIV-related health complications and treatments
- Syphilis Diagnosis and Treatment
- HIV/AIDS drug development and treatment
- Disaster Management and Resilience
- Viral Infections and Outbreaks Research
- Hepatitis C virus research
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV/AIDS Impact and Responses
- T-cell and Retrovirus Studies
- Healthcare Systems and Challenges
- Chronic Kidney Disease and Diabetes
- Ureteral procedures and complications
- Female Genital Mutilation/Cutting Issues
- Animal Disease Management and Epidemiology
- Hepatitis Viruses Studies and Epidemiology
- Air Quality and Health Impacts
Newcastle upon Tyne Hospitals NHS Foundation Trust
2020-2024
Newcastle University
2015-2023
Clinical Research Institute
2023
University of Newcastle Australia
2023
Newcastle upon Tyne Hospital
2022
Barts Health NHS Trust
2022
County Durham and Darlington NHS Foundation Trust
2016-2018
Mount Sinai Hospital
2018
Institute for Health Metrics and Evaluation
2017
Durham University
2015
The NADPH oxidase (NOX) family of enzymes catalyzes the formation reactive oxygen species (ROS). NOX not only have a key role in variety physiological processes but also contribute to oxidative stress certain disease states. To date, while numerous small molecule inhibitors been reported (in particular for NOX2), none demonstrated inhibitory activity vivo. As such, there is need identification improved enable further evaluation biological functions vivo as well therapeutic potential...
Objective To examine the level of stated compliance with public health pandemic influenza control measures and explore factors influencing cooperation for in Australia.Methods A computer-assisted telephone interview survey was conducted by professional interviewers to collect information on Australian public's knowledge willingness comply measures.The sample randomly selected using an electronic database printed directories ensure representativeness from all states territories.After we...
The WHO recommends that men who have sex with (MSM) reporting unprotected receptive anal intercourse (RAI) and either multiple partners or a partner sexually transmitted infection (STI) in the past 6 months should be presumptively treated for asymptomatic rectal Neisseria gonorrhoeae (NG) Chlamydia trachomatis (CT) infections. We evaluated this recommendation cohort of 'high-risk' MSM Coastal Kenya.We assessed presence genitourinary symptoms, determined prevalence 3-month incidence NG CT...
Introduction Young people aged 18–24 years old are a key demographic target for eliminating HIV transmission globally. Pre-exposure prophylaxis (PrEP), prevention medication, reduces transmission. Despite good uptake by gay and bisexual men who have sex with men, hesitancy to use PrEP has been observed in other groups, such as young from ethnic minority backgrounds. The aim of this study was explore people’s perceptions attitudes using PrEP. Design A qualitative transcendental...
We have recently reported high levels of fluoroquinolone resistance in a single region Kenya. In this article, we report prevalence (53.2%) Neisseria gonorrhoeae isolates from 4 clinics 3 additional regions These findings highlight the need to change first-line treatment these settings and evaluate empirical management guidelines for gonococcal infection
Background While bacterial sexually transmitted infections (STIs) are important cofactors for HIV transmission, STI control has received little attention in recent years. The aim of this study was to assess treatment and testing referral practices among health providers Kenya. Methods In 2011 we assessed quality case management male urethritis at pharmacies, private clinics government facilities coastal Kenya using simulated visits pharmacies interviews facilities. Quality Ministry Health...
<h2>Summary</h2><h3>Objectives</h3> HTLV-1 is predominantly a sexually-transmitted infection but testing not mentioned in HIV-PrEP guidelines. We ascertained HTLV-1/HTLV-2 seroprevalence amongst users England. <h3>Methods</h3> An unlinked anonymous study. <h3>Results</h3> Amongst 2015 users, 95% were men, 76% of white ethnicity and 83% had been born Europe. There no seropositive cases (95% confidence interval 0% – 0.18%). <h3>Conclusions</h3> HTLV positive cases, likely reflecting the...
BASHH guidelines recommend that ‘the hepatitis A virus total antibody test can be offered to at-risk patients whose immune status is unknown … depending on local funding arrangements’. We sought measure the prevalence of anti-hepatitis (HAV) IgG in HIV-negative men who have sex with (MSM), inform utility pre-vaccination screening. assessed anti-HAV MSM attended sexual health services County Durham and Darlington, UK, from March August 2017. Data were extracted electronic patient records...
Background Establishing effective postnatal contraception is essential for HIV-seropositive women to avoid the risk of unwanted pregnancy and minimise HIV transmission HIV-seronegative partners. The authors describe their experience providing who attend a community-based integrated sexual health clinic. Methods performed retrospective case note review all received care in term at clinic from September 2000 October 2010. Results A total 107 pregnancies among 95 were eligible review....
In 2019 the British Association for Sexual Health and HIV (BASHH) guidelines management of gonorrhoea were updated. Epidemiological treatment was reserved sexual contacts presenting within 14 days exposure only. The aim this evaluation to review potential implications new on contacts. For retrospective service evaluation, all two UK health services in 2018 identified using Genitourinary Medicine Clinic Activity Dataset (GUMCAD) code Partner notification: contact (PNG). Demographics, clinical...
Hypophosphataemia with tenofovir (TDF) treatment has been well described. The role of HIV infection and other antiretroviral (ART) agents in hypophosphataemia received less attention. aim this study was to determine the prevalence HIV-positive adults. We measured fasting plasma phosphate level estimated glomerular filtration rate (eGFR) 123 patients. A total 26% had 11% grades 2-4 (0.65 mmol/L or less). any grade more frequent those who were ART-treated than ART-naive (35% versus 10%; P =...
Professional bodies in the UK (BASHH/BHIVA) do not currently recommended pre‐exposure prophylaxis (PREP) to prevent HIV aquisition for men who have sex with (MSM) [ 1 ]. Conversely, although Federal Drug Administration approval is awaited, Centers Disease Control (CDC) issued clinicians USA interim guidance facilitate PREP prescriptions 2 Increasingly patients search internet information on treatment, but disparate international policy can lead confusing patient messages. This study was...
The management of HIV in pregnancy has evolved significantly over the past 10 years as our experience combination antiretroviral therapy (ART) grown. We reviewed 109 pregnancies which were managed at community-based integrated and sexual health clinic to investigate preconception antenatal care, trends ART time. document an increasing proportion mother was aware her status pre-conception conception on ART. Pre-conception care sought a minority cases, many women did not present for first...
Background Several preclinical and clinical studies demonstrated a strong correlation between androgen receptor (AR) signaling bladder tumorigenesis. This study aims to evaluate the prognostic significance of AR expression in metastatic urothelial carcinoma (mUC). Methods Samples from phase III trial (LaMB, NCT00949455) which compared maintenance lapatinib versus placebo after completion first-line platinum-based chemotherapy patients with HER 1/2-positive mUC were collected. Corresponding...
A re-audit of prescribing post-exposure prophylaxis for HIV following sexual exposure in the Thames Valley demonstrated that an updated proforma has led to significant improvements clinician-led outcomes, but had no impact on completion or follow-up rates.
<h3>Background/introduction</h3> County Durham and Darlington NHS Foundation Trust (CDDFT) recently published local standards of care for patients disclosing sexual assault within the health service. CDDFT is sole provider services throughout county, offering fully integrated GUM, Family Planning HIV clinics. <h3>Aim(s)/objectives</h3> This study aims describe current management Sexual Health Services. <h3>Methods</h3> Patients who disclosed an alleged from 01.01.2014–31.12.2014 were...
Abstract The mortality associated with HIV has declined since the introduction of combination antiretroviral therapy (cART) and life expectancy for those who begin treatment early enough is now approaching that general population. However, key concerns in maintaining long‐term control are side‐effects convenience/adherence. This review will discuss available recently introduced treatments, potential future therapies currently under investigation.
<h3></h3> Since 2004, we have run a fortnightly in-reach sexual health clinic in medium security male prison which houses 1200 inmates, with specific wing for men who committed drugs related offences. In 2007, reported that the prevalence of Hepatitis C (HCV) prisoners tested was 9% [1]. then, there has been increased awareness burden HCV settings and new recommendations to increase testing [2]. We aimed review current local prisoner screens, compare this firstly, our previous 2007 estimate,...
treatment is restarted and continued for a further 12 weeks.We agree with the authors that selfadministered subcutaneous heparin safe effective has revolutionised manage- ment of thromboembolism pregnancy; we would encourage patients on long-term anticoagulants to discontinue oral warfarin change self-administered well before conception takes place.