A5035212343- Corneal Surgery and Treatments
- Ocular Surface and Contact Lens
- Advanced Drug Delivery Systems
- Electrospun Nanofibers in Biomedical Applications
- Biosensors and Analytical Detection
- Advanced biosensing and bioanalysis techniques
- Advanced Biosensing Techniques and Applications
- 3D Printing in Biomedical Research
- Nanoparticle-Based Drug Delivery
- Chemokine receptors and signaling
- Nanoplatforms for cancer theranostics
- Tissue Engineering and Regenerative Medicine
- Retinal Development and Disorders
- Cancer Immunotherapy and Biomarkers
- Corneal surgery and disorders
- Inflammatory Biomarkers in Disease Prognosis
- Infectious Aortic and Vascular Conditions
- Innovative Microfluidic and Catalytic Techniques Innovation
- Retinal Diseases and Treatments
- Lanthanide and Transition Metal Complexes
- Hernia repair and management
- Wound Healing and Treatments
- Polymer Surface Interaction Studies
- Dendrimers and Hyperbranched Polymers
- Bacillus and Francisella bacterial research
Baylor College of Medicine
2015-2024
Rice University
2022-2024
Houston Methodist
2012-2017
Ocular Surface Center
2015
Methodist Hospital
2012
Purdue University West Lafayette
2003-2010
Mayo Clinic
2007
Akina (United States)
2006
RIKEN
2003
Presently, eye injuries are treated by topical drop therapy. Because of the ocular surface barriers, drops must be applied several times in a day, causing side effects such as glaucoma, cataract, and poor patient compliance. This article presents development nanowafer drug delivery system which polymer work synergistically to elicit an enhanced therapeutic efficacy with negligible adverse immune responses. The is small transparent circular disc that contains arrays drug-loaded...
The mechanism by which immune cells regulate metastasis is unclear. Understanding the role of in will guide development treatments improving patient survival.We used syngeneic orthotopic mouse tumour models (wild-type, NOD/scid and Nude), employed knockout (CD8 CD4) administered CXCL4. Tumours lungs were analysed for cancer bioluminescence, circulating isolated from blood. Immunohistochemistry on tumours was performed to confirm cell type, a tissue microarray with 180 TNBCs human relevance....
Abstract Development of inflammation modulating polymer scaffolds for soft tissue repair with minimal postsurgical complications is a compelling clinical need. However, the current standard care meshes hernia highly inflammatory and initiates dysregulated process causing visceral adhesions complications. Herein, development an biomaterial scaffold (bioscaffold) presented. The bioscaffold design based on idea that, if excess proinflammatory cytokines are sequestered from site injury by...
We describe an integrated approach for detection of diagnostic markers using in situ assembled optical diffraction gratings combination with immunomagnetic capture. Folate receptor (FR), a serum protein indicative various cancers, was chosen as model system to demonstrate the potential method. Magnetic beads coupled FR antibody were used capture from serum. The FR-bound magnetic self-assembled onto microcontact-printed folate-coupled BSA (F−BSA) patterns form which served detect by measuring...
Purpose: To evaluate the efficacy of a controlled release dexamethasone delivery system for suppressing inflammation in an ocular burn + desiccating stress (OB+DS) model. Methods: Nanowafers (NW) loaded with Dexamethasone (Dex, 10 μg) or vehicles (2.5% Methylcellulose; MC) were fabricated using hydrogel template strategy. C57BL/6 mice subjected to unilateral alkali concomitant 2 5 days and topically treated either μL 0.1% Dex vehicle four times per day compared that had MC-NW Dex-NW placed...
Inherited retinal degeneration (IRD) can cause a wide range of different forms vision loss and blindness, in spite extensive advancements gene therapy research, therapeutic approaches for targeting IRDs are still lacking. We have recently developed an approach the intravitreal co-delivery hyaluronic-acid nanospheres (HA-NSs) with sulfotyrosine (ST), effectively reaching outer retina from vitreal cavity. Here, our goal was to understand whether DNA-filled HA-NSs could generate expression...
High-risk (HR) corneal transplantation presents a formidable challenge, with over 50% of grafts experiencing rejection despite intensive postoperative care involving frequent topical eyedrop administration up to every 2 h, gradually tapering 6-12 months, and ongoing maintenance dosing. While clinical evidence underscores the potential benefits inhibiting angiogenesis, effective antiangiogenesis therapy remains elusive in this context. Here, we engineered controlled-release nanomedicine...
We report a broadly applicable optical method for rapid and label-free detection of as few 45 cells. In this method, bacterial cells are detected by measuring the amount laser light transmitted through small glass well functionalized with antibodies which specifically recognize capture The described approach is simple, rapid, economical, promising portable high-throughput wide variety pathogenic infectious
Current methods to screen for bacterial contamination involve using costly reagents such as antibodies or PCR time-costly growth in cultures. There is need portable, real-time, multiplex pathogen detection technology that can predict the safety of food. Surface plasmon resonance (SPR) imaging a sensitive, label-free method detect binding an analyte surface by changes refractive index occur upon binding. We have designed hybrid microfluidic biochip perform multiplexed single-celled pathogens...
A synergy between the polymer biomaterial and drug plays an important role in enhancing therapeutic efficacy, improving stability, minimizing local immune responses development of delivery systems. Particularly, case ocular delivery, need for synergistic system becomes more pronounced because wet mucosal surface highly innervated cornea, which elicit a strong inflammatory response to instilled formulations. This article presents cysteamine nanowafer treat corneal cystinosis. Corneal...
Diseases affecting the retina, such as age-related macular degeneration (AMD), diabetic retinopathy, edema, and retinal vein occlusions, are currently treated by intravitreal injection of drug formulations. These disease pathologies driven oxidative damage due to chronic high concentrations reactive oxygen species (ROS) in retina. Intravitreal injections often induce detachment, intraocular hemorrhage, endophthalmitis. Furthermore, severe eye pain associated with these lead patient...
Nonfunctionalized and functionalized fluorographene systems are studied of which acid system shows greater magnetic moment. This is experimentally verified the hysteresis low temperature studies reveal paramagnetic behaviour. The inherent paramagnetism along with fluorine content utilized in its development as a dual modal agent for proton 19F MRI. As service to our authors readers, this journal provides supporting information supplied by authors. Such materials peer reviewed may be...
The authors report experiments with a diffraction-based biosensor based on self-assembly of target-containing nanobeads that form optical diffraction gratings. They demonstrate the signal is function bead size, and noise minimized by normalizing intensities modes. characterize dependence equivalent size potential scheme in detecting biologically significant molecules.
An optical biosensor integrated with short peptide ligands for detection of Bacillus anthracis spores is described. A that can bind specifically to B. was synthesized and used as the ligand. With this approach, a minimum 34 anthracis, captured on sensor, were detected by measuring laser light transmission intensity verified scanning confocal fluorescence microscopy. The differential nature measurement reduces incidence false positives. process, from capturing sensor surface measurements,...
I saw the SAH: Clinically relevant concentrations of S-adenosyl homocysteine (SAH) can be rapidly detected using self-assembled diffraction gratings. SAH bound to antibody-conjugated (Ab) microbeads (see picture) and then incubated with a gold chip functionalized SAH-specific aptamer in alternating line patterns produces gratings that are by optical intensity measurements (detection limit: 64 pmol L−1). Supporting information for this article is available on WWW under...
Surgical wound healing applications require bioprosthetics that promote cellular infiltration and vessel formation, metrics associated with increased mechanical strength resistance to infection. Porcine acellular lung matrix is a novel tissue scaffold known cell adherence while minimizing inflammatory reactions. In this study, we evaluate the capacity of porcine sustain cellularization neovascularization in rat model subcutaneous implantation chronic hernia repair. We hypothesize that,...
Our previous studies on low molecular weight hydrotropes showed that nicotinamide derivatives increased the aqueous solubility of paclitaxel by several orders magnitude. We were interested in knowing whether polymeric forms those could maintain hydrotropic properties. N-Picolylnicotinamide (PNA) was one best identified for paclitaxel, and polymers based PNA synthesized tested their The pendent moieties attached to polymer backbone through either an oligo(ethylene glycol) or a phenyl group as...