A5047490964- Extracellular vesicles in disease
- RNA Interference and Gene Delivery
- Immune Response and Inflammation
- Hepatocellular Carcinoma Treatment and Prognosis
- Asthma and respiratory diseases
- PI3K/AKT/mTOR signaling in cancer
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- interferon and immune responses
- Ocular Diseases and Behçet’s Syndrome
- Cytomegalovirus and herpesvirus research
- Salmonella and Campylobacter epidemiology
- Lung Cancer Treatments and Mutations
- COVID-19 Impact on Reproduction
- Cell Adhesion Molecules Research
- Neonatal Respiratory Health Research
- Liver physiology and pathology
- Immune cells in cancer
- Cancer-related Molecular Pathways
- Cancer, Hypoxia, and Metabolism
- Legionella and Acanthamoeba research
- Advanced Drug Delivery Systems
- Cancer Mechanisms and Therapy
- Antimicrobial Peptides and Activities
- Nanoplatforms for cancer theranostics
- Biopolymer Synthesis and Applications
Bilkent University
2010-2025
Activation of the PI3K/Akt/mTOR pathway is an important signaling mechanism involved in development and progression liver cancer stem cell (LCSC) population during acquired Sorafenib resistance advanced hepatocellular carcinoma (HCC). Therefore, identification novel therapeutic targets involving this acting on LCSCs highly essential. Here, we analyzed bioactivities molecular pathways action small-molecule inhibitors comparison with Sorafenib, DNA intercalators, DAPT (CSC inhibitor)...
This study aimed to develop and evaluate a CpG oligodeoxynucleotide (CpG ODN)-adjuvanted trivalent inactivated Salmonella vaccine including S. enterica subsp. Enterica serovar Typhimurium, Enteritidis, serotype Infantis, for its immunogenic efficacy in chickens. The immunomodulatory effects of various ODNs were assessed based on proinflammatory cytokine secretion the expression levels CD80, CD86, MHC-II chicken cell lines HD11 DT40. According results, D35 3CG PO, MB, 1466 Acore K3 which...
Recognition of pathogen‐derived nucleic acids by immune cells is critical for the activation protective innate responses. Bacterial cyclic dinucleotides (CDNs) are small that directly recognized cytosolic DNA sensor STING (stimulator IFN genes), initiating a response characterized proinflammatory cytokine and type I production. Strategies to improve stimulatory activities CDNs can further their potential clinical development. Here, we demonstrate simple complex cylic‐di‐GMP with...
<b><i>Background:</i></b> Obese asthma is a complex syndrome with certain phenotypes that differ in children and adults. There no clear evidence regarding the presence of additive or synergistic pathological interaction between obesity children. <b><i>Objectives:</i></b> Our aim was to demonstrate terms airway systemic inflammation by controlled observational study. <b><i>Methods:</i></b> Four groups were formed: obese...
Behçet's disease (BD) activity is characterised by sustained, over-exuberant immune activation, yet the underlying mechanisms leading to active BD state are poorly defined. Herein, we show that human cathelicidin derived antimicrobial peptide LL37 associates with and directs plasma extracellular vesicles (EV) cells, thereby enhanced activation aggravating pathology. Notably, was correlated elevated levels of circulating EV concentration. Stimulation healthy PBMC patient EVs induced...
Reduced immune activation or immunosuppression is seen in patients withneurological diseases. Urinary and respiratory infections mainly manifested as septicemia pneumonia are the most frequent complications following spinal cord injuries they account for majority of deaths. The underlying reason these losses believed to arise due impaired responses pathogens. Here, we hypothesized that susceptibility chronic injured (SCI) might be impairment recognition pathogen associated molecular patterns...
The effects of the bcsE gene and BcsE protein on bacterial physiology pathogenicity in SalmonellaTyphimurium Salmonella Group C1 were investigated. It was observed that biofilm pellicle formation did not occur mutants wild-type strains. Besides, 'rdar' (red, dry, rough) morphotype strains changed significantly mutants. In terms gene, swimming swarming motility mutant showed a dramatic increase compared to cloned into Escherichia coli BL21, his-tagged produced this strain purified obtain...
Eksozomlar bilinen tüm hücreler tarafından ortama salınan nanokeseciklerdir.1980'li yıllarda ilk keşiflerini takiben sadece istenmeyen molekülleri hücre dışına atmaktan sorumlu artıkları olarak anılsalar da son 20 yılda yapılan çalışmalar bu keseciklerin önemli fizyolojik görevleri olduğunu ortaya çıkarmıştır
Background The COVID-19 pandemic has caused significant morbidity and mortality globally. role of plasma-derived extracellular vesicles (EVs) in pediatric patients remains unclear.
Abstract Liver cancer stem cells (LCSCs) are derived from damaged and transformed Hepatic progenitor (HPCs) during precancerous cirrhosis stage. Ras/Raf/MAPK PI3K/AKT/mTOR signaling pathways significantly deregulated in liver cancer. The activation of pathway LCSC population is one the reasons for acquired resistance to Sorafenib advanced Hepatocellular carcinoma (HCC) patients. Therefore, identifying novel inhibitors targeting this acting on LCSCs highly essential. We therefore elucidated...
Abstract Liver cancer stem cells (LCSCs) are derived from damaged and transformed hepatic progenitor (HPCs) during precancerous cirrhosis stage. Ras/Raf/MAPK PI3K/AKT/mTOR signaling pathways significantly deregulated in liver cancer. The activation of pathway LCSC population is one the reasons for acquired resistance to sorafenib advanced hepatocellular carcinoma (HCC) patients. Therefore, identifying novel inhibitors targeting this acting on LCSCs highly essential. We, therefore, elucidated...
Abstract Microparticles (MP) are small vesicles secreted from immune and non-immune cells their diameter ranges 200 to 700nm. Studies demonstrated that MP number source varies in several disease conditions. Therefore, we plan characterize the cell source, activation state levels of MPs different clinical states Behcet`s Syndrome (BS) asthma. Isolated were stained with Annexin V specific CD markers (i.e. CD42a, CD69, CD105, CD31 CD146). Number marker MP/ml blood was detected by FACS. In case...
Congress of the European-Academy-of-Allergy-and-Clinical-Immunology (EAACI) - MAY 26-30, 2018 Munich, GERMANY