A5111775703- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Parathyroid Disorders and Treatments
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Hematological disorders and diagnostics
- Respiratory Support and Mechanisms
- Diabetic Foot Ulcer Assessment and Management
- Clinical Laboratory Practices and Quality Control
- Blood groups and transfusion
- Diabetes Treatment and Management
- Inflammatory Biomarkers in Disease Prognosis
- Pancreatitis Pathology and Treatment
- Healthcare Systems and Public Health
- Pericarditis and Cardiac Tamponade
- Potassium and Related Disorders
- Advanced Scientific Research Methods
- Intensive Care Unit Cognitive Disorders
- Advanced Computational Techniques in Science and Engineering
- Blood properties and coagulation
- Cardiac Imaging and Diagnostics
- Heparin-Induced Thrombocytopenia and Thrombosis
- Blood Pressure and Hypertension Studies
- Platelet Disorders and Treatments
Medical University of Vienna
2019-2024
Hôtel-Dieu de Paris
1980-1987
Background: In patients with transthyretin amyloid cardiomyopathy, tafamidis was shown to slow the decline in 6-minute walking distance as compared placebo. We aimed define impact of and optimal background treatment on functional capacity determined by cardiopulmonary exercise testing (CPET). Methods: Seventy-eight consecutive were enrolled study. They underwent CPET at baseline, outcome defined death or heart failure hospitalization obtained for a time period up 30 months. Fifty-four...
We aimed to identify cardiopulmonary long-term effects after severe COVID-19 disease as well predictors of Long-COVID in a prospective registry. A total 150 consecutive, hospitalized patients (February 2020 and April 2021) were included six months post hospital discharge for clinical follow-up. Among them, 49% experienced fatigue, 38% exertional dyspnea 75% fulfilled criteria Long-COVID. Echocardiography detected reduced global longitudinal strain (GLS) 11% diastolic dysfunction 4%. Magnetic...
Abstract Background Pericardial and pleural effusion are common findings in patients with cardiac amyloidosis (CA). It is not known, whether effusions correlate right ventricular (RV) function these patients. Furthermore, data on the prognostic significance of pericardial CA scarce. Methods Patients transthyretin (ATTR) light chain (AL) were included a clinical registry. All underwent transthoracic echocardiography at baseline. The presence was determined every patient. endpoint defined as...
This study sought to characterize cardiac amyloidosis (CA) patients with respect hemodynamic parameters and asses their prognostic impact in different CA cohorts. Intracardiac pulmonary arterial pressures (PAPs) are among the strongest predictors of outcomes heart failure (HF). Despite that, profiles relation prognosis have rarely been investigated. Invasive hemodynamic, clinical, laboratory assessment, as well magnetic resonance imaging were performed our cohort. A total 61 patients, 35...
Introduction SARS-CoV-2 infection affects the cardiopulmonary system in acute as well long-term phase. The aim of present study was to comprehensively assess symptoms and possible impairments 6 18 months after hospitalization for severe COVID-19 infection. Methods This prospective registry included patients with PCR-confirmed requiring hospitalization. Follow-up approximately post discharge comprised a detailed patient history, clinical examination, transthoracic echocardiography,...
Abstract Aims Amyloid cardiomyopathy is caused by the deposition of light chain (AL) or transthyretin amyloid (ATTR) fibrils, that leads to a restrictive cardiomyopathy, often resulting in heart failure (HF) with preserved reduced ejection fraction. This study aimed determine whether cardiac output reduction ventilation inefficiency plays predominant role limiting exercise patients cardiomyopathy. Methods We conducted multicentre prospective AL ATTR who underwent cardiopulmonary testing...
Drugs which interact with the renin angiotensin aldosterone system (RAAS) aim to reduce negative effects of (Ang) II. Treatment these drugs anticipate a compensatory up-regulation renin; however, it has been shown that there is large variability in circulating plasma (PRA), even patients optimal medical therapy heart failure (HF) reduced ejection fraction (HFrEF). Our was measure activity (PRA-S), its response RAAS inhibitor (RAASi) therapies and on outcome HF preserved (HFpEF). For this...
Abstract Background SARS-CoV-2 infection affects the cardiopulmonary system in both acute and long-term phase. This study aimed to comprehensively assess symptoms potential longterm impairments 6, 18 30 months patients previously hospitalized for severe Covid-19 infection. Methods prospective registry included PCR-confirmed Approximately 6 post-discharge, follow-up examination patient history, clinical examination, echocardiography, electrocardiogram, cardiac magnetic resonance imaging...
Background Little evidence is available about heart rate (HR) response to exercise as well its relationship with functional capacity in amyloid cardiomyopathy. Then, a multicentre cohort of patients cardiomyopathy, we investigated the prevalence chronotropic incompetence (CI) and relationships cardiopulmonary testing (CPET) variables. Methods Data from 172 outpatients cardiomyopathy who performed maximal CPET had no significant rhythm disorders were analysed. Results The CI differed...
Abstract Background Transthyretin amyloid cardiomyopathy (ATTR-CA) is caused by deposition of fibrils in the myocardium. The occurs when transthyretin (TTR) becomes unstable and misfolds. Tafamidis a kinetic stabilizer TTR that prevents tetramer dissociation amyloidogenesis TTR. Methods Eighteen patients with diagnosis ATTR-CA (hATTR or wtATTR) from our national amyloidosis registry were treated 20 mg tafamidis for period six months. In explorative analysis we aimed to evaluate effects...
In a previous work, we have compared two automated techniques for platelet‐rich plasma using thrombocounter or whole blood with the continuous flow instrument Auto‐analyzer (AA). More recently, tested instruments blood: first one, fully automated: Coulter S+; and other semi‐automated: Clay‐Adams. present these 4 methods are to phase contrast microscope technique, used as reference. The coefficients of variation ranged betweeen 2 13 per cent. correlation between different were 0.92 0.96....
Abstract Background Apical sparing describes a reduced longitudinal strain in the basal segments and preserved or supranormal apical of left ventricular (LV) myocardium. This pattern has been described as typical finding patients with cardiac amyloidosis (CA) restrictive cardiomyopathy. However, is not quantitative parameter fairly subjective to echocardiographer's judgement. It known, if certain degree also present only mild LV hypertrophy diastolic dysfunction such it heart failure...
Abstract Background Established heart failure (HF) treatments have shown no effects in HF and preserved ejection fraction (HFpEF). Subgroup analyses of the HFpEF populations suggest that certain patients benefit from treatments. This underlines importance individualized therapy regimens HFpEF. Sodium-glucose transporter 2 (SGLT-2) inhibitors are emerging as a promising treatment HF. The mechanisms leading to improved outcomes include 1) diabetes, 2) osmodiuresis preventing volume overload,...
An original observation of platelet agglutination was found in a 63 y.o. man during 5 years following, without spontaneous bleeding. Low counts (10 × 109/liter) and large agglutinates were observed on blood specimens collected into EDTA (1 to 15 mg/ml whole WB), citrate (1/10 volume 0.11 M), sodium heparin (100 units/ml plus acetyl salicylic acid (5 100 prostacyclin (Upjohn 10−5 10−6 M)? buffering anticoagulant (0.8 M citrate, pH 4.65). count also capillary obtained by finger puncture kept...