A5027974014- Soil and Environmental Studies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Agricultural Productivity and Crop Improvement
- Parathyroid Disorders and Treatments
- Soil Carbon and Nitrogen Dynamics
- Agriculture and Biological Studies
- Heart Failure Treatment and Management
- Peptidase Inhibition and Analysis
- Environmental Sustainability and Technology
- Pulmonary Hypertension Research and Treatments
- Cardiovascular Function and Risk Factors
- Marine and environmental studies
- Remote Sensing in Agriculture
- Scientific Research Methodologies and Applications
- Diabetes Treatment and Management
- Medical Imaging and Pathology Studies
- Blood Pressure and Hypertension Studies
- Dialysis and Renal Disease Management
- Economic and Technological Systems Analysis
- Advanced MRI Techniques and Applications
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Lung Cancer Treatments and Mutations
- Sarcoidosis and Beryllium Toxicity Research
- Lung Cancer Diagnosis and Treatment
- Cardiovascular Issues in Pregnancy
Medical University of Vienna
2023-2025
V.V. Dokuchaev Soil Science Institute
2019-2024
Background: This study assessed the prognostic value of submaximal cardiopulmonary exercise testing (CPET) in cardiac amyloidosis and explored CPET as an alternative to 6-min walk test (6MWT).
Abstract Aims We aimed to establish one-minute sit-to-stand test (1-min STST) cut-off values that align with the guideline-recommended six-minute walk (6MWT) thresholds (165m and 440m) for one-year mortality risk stratification in pulmonary hypertension (PH) patients. Furthermore, we compare clinical characteristics long-term among patients stratified by these proposed 1-min STST cut-offs. Methods All performed 6MWT. Receiver operating analysis was determine cut-offs corresponding 6MWT...
Introduction. Several randomised double-blind placebo-controlled phase III trials (RCT) explore disease-modifying therapeutics in transthyretin amyloid cardiomyopathy (ATTR-CM). However, it is currently unclear whether patients eligible to participation the RCT are representative of real-world patients. Methods. ATTR-CM presenting a tertiary referral centre for cardiac amyloidosis at Medical University Vienna between March 2012 and May 2024 were included prospective registry. Inclusion...
Sodium-glucose cotransporter 2 inhibitors (SGLT2i) have been found to potential hematopoietic effects in patients with heart failure (HF). However, these benefits not studied cardiac amyloidosis (CA). CA present HF symptoms and often suffer from iron deficiency, which has a negative impact on erythropoiesis leads lower hemoglobin hematocrit levels. We sought determine the of SGLT2i hematological parameters functional capacity (FC) patients. A prospective analysis was conducted compare who...
Aims Patients with transthyretin amyloid cardiomyopathy (ATTR-CM) experience reduced functional capacity. We evaluated changes in capacity over extensive follow-up using cardiopulmonary exercise testing (CPX). Methods ATTR-CM patients underwent CPX and blood at baseline, first [V1, 8 (6–10) months] second (V2) 35 (26–41) months after start of disease-specific therapy. Results included 34 patients, aged 77 (±6) years (88.2% men). showed two patterns improvement V1 deterioration V2. Peak work...
Heart failure with preserved ejection fraction (HFpEF) is associated heart (HF) hospitalizations and death. Previous studies have shown that altered muscle composition higher risk of adverse outcome in HFpEF patients.
Transthyretin amyloid cardiomyopathy (ATTR-CM) is associated with severely impaired health-related quality of life (HRQL). HRQL an independent predictor outcome in heart failure (HF), but data on patients ATTR-CM scarce. This study therefore aims to evaluate the association ATTR-CM.
Background: The pathophysiology of heart failure (HF) with preserved ejection fraction (HFpEF) is suggested to be influenced by inflammation. Leukocyte indices, including the neutrophil–lymphocyte ratio (NLR), monocyte–lymphocyte (MLR), and pan-immune inflammation value (PIV), can utilized as biomarkers systemic Their prognostic utility yet fully understood. Methods: Between December 2010 May 2023, patients presenting a tertiary referral center for HFpEF were included into prospective...
Abstract Aims Quantification of cardiac [99mTc]-3,3-diphosphono-1,2-propanodicarboxylic acid (DPD) uptake enhances diagnostic capabilities and may facilitate prognostic stratification in patients with transthyretin amyloidosis (ATTR-CA). This study aimed to evaluate the association quantitative left ventricular (LV) DPD myocardial structure function, their implications on outcome ATTR-CA. Methods Results Consecutive ATTR-CA (n=100) undergoing planar scintigraphy Perugini grade 2 or 3,...
Abstract Aims Amyloid cardiomyopathy is caused by the deposition of light chain (AL) or transthyretin amyloid (ATTR) fibrils, that leads to a restrictive cardiomyopathy, often resulting in heart failure (HF) with preserved reduced ejection fraction. This study aimed determine whether cardiac output reduction ventilation inefficiency plays predominant role limiting exercise patients cardiomyopathy. Methods We conducted multicentre prospective AL ATTR who underwent cardiopulmonary testing...
Abstract. The research aim is to assess the degree of deflation when comparing traditional crop cultivation technology using soil treatment and no-till. Object located on territory Ipatovsky district Stavropol territory, where method evaluating ordinary chernozems (WRB 2006 Voronic Chernozems Pachic) by morphometric indicators properties profile has been tested example 2 farms different technologies. Methods. In this research, a for estimating was used, based measuring capacity humus horizon...
Abstract Introduction Cardiac magnetic resonance imaging (cMRI) stands as a crucial non-invasive diagnostic tool for monitoring disease progression in individuals with cardiac amyloidosis (CA). Limited functional capacity (FC), assessed by cardiopulmonary exercise testing (CPET) has been described CA several studies. The aim of this study was to identify potential concurrent relationships between the two modalities. Methods 112 patients diagnosed (CA) were evaluated. Patients aged 77 ± 7...
Abstract Introduction Pulmonary hypertension (PH) often leads to reduced functional capacity, commonly assessed by the six-minute walk test (6MWT). The 1-min sit-to-stand (1-min STST) is a shorter with smaller space requirements. Despite its potential utility, our knowledge no studies have determined optimal cut-off value for STST in patients PH. Aim This study aimed assess utilizing three established 6MWT thresholds (165m, 320m, and 440m) recommended current European PH guidelines published...
Abstract Introduction Cardiac transthyretin amyloidosis (ATTR) represents a heart failure phenotype often accompanied by pulmonary hypertension. The artery to aorta ratio (PA/Ao), as assessed on cardiac computed tomography or magnetic resonance (CMR), has demonstrated indicate risk for adverse events in variety of cardiovascular diseases, particularly and However, its prognostic value ATTR remains unknown. Aim We aimed investigate the PA/Ao patients with ATTR. Methods Data consecutive...
Abstract Background Along with the aging population, incidence of concomitant heart failure preserved ejection fraction (HFpEF) and cancer, is increasing. However, little known about typical characteristics patients both HFpEF a history oncologic disease. Aim We aimed to characterize distinctive outcomes cancer within prospective registry. Methods analyzed data from 491 unselected our tertiary university center between 2010 2022 followed until 2023. Laboratory parameters comorbidities were...
Abstract Introduction The indexed total extracellular volume of the myocardium (iECV) has recently been proposed to be superior in predicting adverse outcome severe aortic stenosis as compared conventional (ECV). So far, no study assessed comparative predictive performance both measures transthyretin amyloid cardiomyopathy (ATTR-CM). Aim We aimed assess and compare ECV against iECV determining outcomes patients with ATTR-CM. Methods From 2012 2023, ATTR-CM undergoing contrast cardiac...
Abstract Introduction Sodium–glucose cotransporter 2 inhibitors (SGLT2i) have been revealed to potential hematopoietic effects in patients with heart failure (HF), leading an improvement clinical outcome. However, these benefits not studied cardiac amyloidosis (CA), despite CA often causing symptoms of (HF) and contributing iron-deficient state, which further complicates by limiting erythropoiesis lowering haemoglobin haemotocrit levels. We aimed determine the SGLT2i improving haematological...
Abstract Background Exercise oscillatory ventilation (EOV) signals multiple abnormalities in hemodynamics and ventilatory control which may predict poor outcome patients with cardiac diseases. Purpose To assess whether EOV (+) amyloid cardiomyopathy show higher mortality rates compared to their counterparts without EOV. Methods We analyzed cardiopulmonary exercise testing results for defined by continuous (>60% of duration) oscillations minute (VE), cycling a frequency one an...