A5038184224- Amyloidosis: Diagnosis, Treatment, Outcomes
- Parathyroid Disorders and Treatments
- Pulmonary Hypertension Research and Treatments
- Cardiovascular Function and Risk Factors
- Medical Imaging and Pathology Studies
- Heart Failure Treatment and Management
- Blood Pressure and Hypertension Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiovascular and exercise physiology
- Cardiomyopathy and Myosin Studies
- Peptidase Inhibition and Analysis
- Sarcoidosis and Beryllium Toxicity Research
- Diabetes Treatment and Management
- Advanced MRI Techniques and Applications
- Dialysis and Renal Disease Management
- Cardiac, Anesthesia and Surgical Outcomes
- Lung Cancer Treatments and Mutations
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Lung Cancer Diagnosis and Treatment
- Eosinophilic Disorders and Syndromes
- Inflammatory Biomarkers in Disease Prognosis
- Chronic Myeloid Leukemia Treatments
- Cardiac Imaging and Diagnostics
- Protein Kinase Regulation and GTPase Signaling
- Cystic Fibrosis Research Advances
Medical University of Vienna
2023-2025
Centro Cardiologico Monzino
2025
University of Milan
2025
University Clinic of Traumatology
2023
Vienna General Hospital
2023
Background The one-minute sit-to-stand-test (1-min STST) is a quick, space saving test to evaluate functional capacity. Exercise testing plays an important role in the long-term follow-up of pulmonary hypertension (PH) patients and currently evaluated using six-minute-walk-test (6MWT). aim study was assess convergent validity 1-min STST with PH its association markers severity. Methods We 106 1-min-STST 6MWT measured cardiorespiratory parameters (heart rate, blood pressure, oxygen...
Novel ribonucleic acid interference (RNAi) therapeutics such as patisiran and inotersen have been shown to benefit neurologic disease course quality of life in patients with hereditary transthyretin amyloidosis (ATTRv). We aimed determine the impact RNAi on myocardial amyloid load using quantitative single photon emission computed tomography/computed tomography (SPECT/CT) imaging ATTRv-related cardiomyopathy (ATTRv-CM). furthermore compared them wild-type ATTR-CM (ATTRwt-CM) treated tafamidis.
Background: This study assessed the prognostic value of submaximal cardiopulmonary exercise testing (CPET) in cardiac amyloidosis and explored CPET as an alternative to 6-min walk test (6MWT).
Abstract Aims We aimed to establish one-minute sit-to-stand test (1-min STST) cut-off values that align with the guideline-recommended six-minute walk (6MWT) thresholds (165m and 440m) for one-year mortality risk stratification in pulmonary hypertension (PH) patients. Furthermore, we compare clinical characteristics long-term among patients stratified by these proposed 1-min STST cut-offs. Methods All performed 6MWT. Receiver operating analysis was determine cut-offs corresponding 6MWT...
Sodium-glucose cotransporter 2 inhibitors (SGLT2i) have been found to potential hematopoietic effects in patients with heart failure (HF). However, these benefits not studied cardiac amyloidosis (CA). CA present HF symptoms and often suffer from iron deficiency, which has a negative impact on erythropoiesis leads lower hemoglobin hematocrit levels. We sought determine the of SGLT2i hematological parameters functional capacity (FC) patients. A prospective analysis was conducted compare who...
Background Cardiopulmonary exercise testing (CPET) is essential for assessing patients with hypertrophic cardiomyopathy (HCM), but the role of pulmonary function (PFT) in refining patient stratification remains underexplored. This study investigates relationship between PFT and CPET parameters HCM. Methods In this prospective two-centre study, 102 clinically stable HCM underwent CPET. Spearman’s correlation multiple linear regression were used to assess relationships (forced vital capacity...
Background/Objectives: Patients with transthyretin amyloid cardiomyopathy (ATTR-CM) often experience significantly reduced functional capacity due to myocardial involvement. Cardiopulmonary exercise testing (CPET) is the gold standard quantify capacity, and 99mTc-DPD scintigraphy SPECT/CT have proven be highly effective tools for diagnostic disease monitoring. We aimed investigate complementary role correlation between both methods, focusing on their combined potential as a strong prognostic...
Aims Patients with transthyretin amyloid cardiomyopathy (ATTR-CM) experience reduced functional capacity. We evaluated changes in capacity over extensive follow-up using cardiopulmonary exercise testing (CPX). Methods ATTR-CM patients underwent CPX and blood at baseline, first [V1, 8 (6–10) months] second (V2) 35 (26–41) months after start of disease-specific therapy. Results included 34 patients, aged 77 (±6) years (88.2% men). showed two patterns improvement V1 deterioration V2. Peak work...
Heart failure with preserved ejection fraction (HFpEF) is associated heart (HF) hospitalizations and death. Previous studies have shown that altered muscle composition higher risk of adverse outcome in HFpEF patients.
Transthyretin amyloid cardiomyopathy (ATTR-CM) is associated with severely impaired health-related quality of life (HRQL). HRQL an independent predictor outcome in heart failure (HF), but data on patients ATTR-CM scarce. This study therefore aims to evaluate the association ATTR-CM.
The pathophysiological hallmark of wild-type transthyretin amyloid cardiomyopathy (ATTRwt-CM) is the deposition within myocardium.
Background: The pathophysiology of heart failure (HF) with preserved ejection fraction (HFpEF) is suggested to be influenced by inflammation. Leukocyte indices, including the neutrophil–lymphocyte ratio (NLR), monocyte–lymphocyte (MLR), and pan-immune inflammation value (PIV), can utilized as biomarkers systemic Their prognostic utility yet fully understood. Methods: Between December 2010 May 2023, patients presenting a tertiary referral center for HFpEF were included into prospective...
Abstract Aims Quantification of cardiac [99mTc]-3,3-diphosphono-1,2-propanodicarboxylic acid (DPD) uptake enhances diagnostic capabilities and may facilitate prognostic stratification in patients with transthyretin amyloidosis (ATTR-CA). This study aimed to evaluate the association quantitative left ventricular (LV) DPD myocardial structure function, their implications on outcome ATTR-CA. Methods Results Consecutive ATTR-CA (n=100) undergoing planar scintigraphy Perugini grade 2 or 3,...
Abstract Aims Amyloid cardiomyopathy is caused by the deposition of light chain (AL) or transthyretin amyloid (ATTR) fibrils, that leads to a restrictive cardiomyopathy, often resulting in heart failure (HF) with preserved reduced ejection fraction. This study aimed determine whether cardiac output reduction ventilation inefficiency plays predominant role limiting exercise patients cardiomyopathy. Methods We conducted multicentre prospective AL ATTR who underwent cardiopulmonary testing...
Growing interest has accrued in the co-existence of cardiac amyloidosis and valvular heart disease. Amyloid infiltration from either transthyretin (ATTR) or light chain (AL) origin may affect any structure heart, including valves. Recent literature mainly focused on aortic stenosis amyloidosis, improving our understanding epidemiology, diagnosis, treatment prognosis this dual pathology. Even though high clinical relevance, data mitral/tricuspid regurgitation is rather scarce mostly limited...
Growing interest has accrued in the co-existence of cardiac amyloidosis and valvular heart disease. Amyloid infiltration from either transthyretin (ATTR) or light chain (AL) origin may affect any structure heart, including valves. The recent literature mainly focused on aortic stenosis amyloidosis, improving our understanding epidemiology, diagnosis, treatment prognosis this dual pathology. Despite being high clinical relevance, data mitral/tricuspid regurgitation are rather scarce mostly...
Patients with pulmonary hypertension (PH) have an impaired functional capacity and poor health-related quality of life (HRQoL). The one-minute sit-to-stand test (1-min STST) can be used for the assessment capacity.
Abstract Introduction Cardiac magnetic resonance imaging (cMRI) stands as a crucial non-invasive diagnostic tool for monitoring disease progression in individuals with cardiac amyloidosis (CA). Limited functional capacity (FC), assessed by cardiopulmonary exercise testing (CPET) has been described CA several studies. The aim of this study was to identify potential concurrent relationships between the two modalities. Methods 112 patients diagnosed (CA) were evaluated. Patients aged 77 ± 7...
Abstract Background The pathophysiological hallmark of transthyretin amyloid cardiomyopathy (ATTR-CM) is the deposition within myocardium. However, association between myocardial load and quantitative cardiac 99mTc-3,3-diphosphono-1,2-propanodicarboxylic acid (99mTc-DPD) uptake barely investigated. Purpose We aimed to investigate relationship 99mTc-DPD load, assessed by extracellular volume (ECV) on magnetic resonance (CMR) imaging, along with function in patients ATTR-CM. Methods Forty...
Abstract Introduction Pulmonary hypertension (PH) often leads to reduced functional capacity, commonly assessed by the six-minute walk test (6MWT). The 1-min sit-to-stand (1-min STST) is a shorter with smaller space requirements. Despite its potential utility, our knowledge no studies have determined optimal cut-off value for STST in patients PH. Aim This study aimed assess utilizing three established 6MWT thresholds (165m, 320m, and 440m) recommended current European PH guidelines published...
Abstract Introduction Cardiac transthyretin amyloidosis (ATTR) represents a heart failure phenotype often accompanied by pulmonary hypertension. The artery to aorta ratio (PA/Ao), as assessed on cardiac computed tomography or magnetic resonance (CMR), has demonstrated indicate risk for adverse events in variety of cardiovascular diseases, particularly and However, its prognostic value ATTR remains unknown. Aim We aimed investigate the PA/Ao patients with ATTR. Methods Data consecutive...
Abstract Background Along with the aging population, incidence of concomitant heart failure preserved ejection fraction (HFpEF) and cancer, is increasing. However, little known about typical characteristics patients both HFpEF a history oncologic disease. Aim We aimed to characterize distinctive outcomes cancer within prospective registry. Methods analyzed data from 491 unselected our tertiary university center between 2010 2022 followed until 2023. Laboratory parameters comorbidities were...
Abstract Introduction The indexed total extracellular volume of the myocardium (iECV) has recently been proposed to be superior in predicting adverse outcome severe aortic stenosis as compared conventional (ECV). So far, no study assessed comparative predictive performance both measures transthyretin amyloid cardiomyopathy (ATTR-CM). Aim We aimed assess and compare ECV against iECV determining outcomes patients with ATTR-CM. Methods From 2012 2023, ATTR-CM undergoing contrast cardiac...