A5050971103- Adipokines, Inflammation, and Metabolic Diseases
- Nuclear Structure and Function
- Peroxisome Proliferator-Activated Receptors
- Adipose Tissue and Metabolism
- RNA Research and Splicing
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Metabolism, Diabetes, and Cancer
- Hormonal Regulation and Hypertension
- Lipoproteins and Cardiovascular Health
- Cancer, Lipids, and Metabolism
- Lipid metabolism and biosynthesis
- Blood properties and coagulation
- Apelin-related biomedical research
- Blood Pressure and Hypertension Studies
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Regulation of Appetite and Obesity
- Cardiovascular Disease and Adiposity
- Renal Diseases and Glomerulopathies
- Endoplasmic Reticulum Stress and Disease
- Liver Diseases and Immunity
- Lipid metabolism and disorders
- Cholesterol and Lipid Metabolism
- S100 Proteins and Annexins
- Cell Adhesion Molecules Research
- Adrenal Hormones and Disorders
Rijnstate Hospital
2018-2022
Amsterdam UMC Location University of Amsterdam
2001-2018
Amsterdam University Medical Centers
2018
University Medical Center Utrecht
2011-2014
Utrecht University
2011-2012
University of Amsterdam
1996-2009
Noninvasive diagnostic methods are urgently required in disease stratification and monitoring nonalcoholic fatty liver (NAFLD). Multiparametric magnetic resonance imaging (MRI) is a promising technique to assess hepatic steatosis, inflammation, fibrosis, potentially enabling noninvasive identification of individuals with active advanced stages NAFLD. To examine the performance multiparametric MRI for assessment severity along NAFLD spectrum comparison histological scores. Prospective,...
Familial partial lipodystrophy (FPLD) results from coding sequence mutations either in LMNA, encoding nuclear lamin A/C, or PPARG, peroxisome proliferator-activated receptor-gamma (PPARgamma). The LMNA form is called FPLD2 (MIM 151660) and the PPARG FPLD3 604367).Our objective was to investigate whether clinical phenotype of this proband due mutation(s) PPARgamma.This a case report. Patient Setting: A 31-yr-old female with FPLD3, i.e. early childhood diabetes extreme insulin resistance...
Abstract Context Primary aldosteronism (PA) confers an increased risk of cardiovascular disease (CVD), independent blood pressure. Animal models have shown that aldosterone accelerates atherosclerosis through proinflammatory changes in innate immune cells; human data are scarce. Objective The objective this article is to explore whether patients with PA arterial wall inflammation, systemic and reprogramming monocytes. Design A cross-sectional cohort study compared vascular inflammation on...
Familial partial lipodystrophy (FPLD) is a rare metabolic disorder with clinical features that may not be readily recognised. As FPLD patients require specific therapeutic approach, early identification warranted. In the present study we aimed to identify cases of among non-obese type 2 diabetes mellitus and marked insulin resistance. We searched databases three diabetic outpatient clinics for resistance, arbitrarily defined as use ≥100 U insulin/day, BMI ≤ 27 kg/m2. all patients, variables...
Abstract Peroxisome proliferator-activated receptor γ (PPARγ) is the master regulator of adipocyte differentiation, and mutations that interfere with its function cause lipodystrophy. PPARγ a highly modular protein, structural studies indicate domains engage in several intra- inter-molecular interactions. How these interactions modulate PPARγ’s ability to activate target genes cellular context currently poorly understood. Here we take advantage two previously uncharacterized lipodystrophy...
The nuclear receptor PPARγ is the master regulator of adipocyte differentiation, distribution, and function. In addition, induces terminal differentiation several epithelial cell lineages, including colon epithelia. Loss-of-function mutations in PPARG result familial partial lipodystrophy subtype 3 (FPDL3), a rare condition characterized by aberrant adipose tissue distribution severe metabolic complications, diabetes. Mutations have also been reported sporadic colorectal cancers, but...
Increased production of chemokines by adipose tissue and defective oxygenation as a result obesity may induce leucocyte infiltration subsequent systemic inflammation.1-To determine the relation between amount visceral subcutaneous chemokine interferon-γ-inducible protein 10 (IP-10) angiogenic factor hepatocyte growth (HGF). 2-To metabolic syndrome IP-10 well HGF.Patients originated from Secondary Manifestations ARTerial disease (SMART) cohort. In this study, cohort 1251 patients with...
We investigated the postprandial changes in plasma levels of adipocytokines overweight patients with metabolic syndrome after an oral fat load. After load and during a prolonged fast, blood was drawn at 0, 2, 3, 4 8 h for measurement adiponectin, adipsin, cathepsin S, chemerin, hepatic growth factor, interferon-γ-inducible protein-10, leptin, macrophage chemoattractant protein-1, migration inhibitory nerve retinol binding protein-4, resistin, serum amyloid A1, tissue inhibitor...
It is conceivable that the extent and spatio-temperal expression of dozens or even a few hundred genes are significantly altered during development progression atherosclerosis as compared to normal circumstances. Differential gene in vascular cells blood cells, due gene-gene gene-environment interactions can be considered molecular basis for this disease. To comprehend coherence complex genetic response systemic local atherosclerotic challenges, one needs accessible high through-put...
Obesity is associated with a prothrombotic state, which may contribute to the increased risk of thrombotic events.To assess effects (pre)adipocyte-derived adipokines on fibrinogen, plasminogen activator inhibitor-1 (PAI-1) and tissue factor (TF) production by hepatocytes.HepG2 hepatocytes were incubated conditioned media (CM) derived from preadipocytes adipocytes, had been untreated or prestimulated tumor necrosis (TNF)-α, interleukin (IL)-1β IL-6. After 24 h, supernatants cell lysates...
Crypt abscesses allow prolonged apposition of activated neutrophils to the epithelial surface colon. Adhesion both vascular endothelium and basolateral membrane share common effector molecules but are distinct processes. This study aimed define mechanisms that effect adhesion, independent transmigration, apical epithelium. HT29 (cl 19A) cells were grown confluency incubated with under conditions of: (i) neutrophil stimulation phorbol-myristate-acetate; (ii) monolayer interferon gamma, tumour...
Genetic lipodystrophies are a group of rare syndromes associated with major metabolic complications - including severe insulin resistance, type 2 diabetes mellitus, and hypertriglyceridemia which classified according to the distribution adipose tissue. Lipodystrophies can be present at birth or develop during life range from local partial general. With least 18 different genes implicated so far, definite diagnosis challenging due clinical genetic heterogeneity. In an adult female patient...
We investigated whether plasma ferritin levels through the pro-inflammatory effects of free iron are associated with adipose tissue dysfunction in a relevant population patients manifest vascular disease who would potentially benefit most from further aetiological insights.In cohort 355 diseases, association between and adiponectin was quantified using linear regression analysis. Interleukin-6 were measured medium pre-adipocytes adipocytes after incubation increasing concentrations...
The inverse correlation between HDL-C and atherosclerotic vascular disease is well established lately research has focused on HDL as a potential target in the treatment of disease. Traditionally, reverse cholesterol transport considered to be most important mechanism by which protects against atherosclerosis. However, recent findings indicate that role an antiatherogenic particle much more complex additional protective mechanisms, such anti-inflammatory antioxidative characteristics. these...