A5100329179- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer-related gene regulation
- RNA modifications and cancer
- Photosynthetic Processes and Mechanisms
- Epigenetics and DNA Methylation
- Algal biology and biofuel production
- Biocrusts and Microbial Ecology
- Plant Virus Research Studies
- Genomics and Phylogenetic Studies
- RNA and protein synthesis mechanisms
- Hedgehog Signaling Pathway Studies
- Tea Polyphenols and Effects
- Traditional Chinese Medicine Analysis
- Vascular anomalies and interventions
- CRISPR and Genetic Engineering
- Meat and Animal Product Quality
- Identification and Quantification in Food
- Pediatric Urology and Nephrology Studies
- Kruppel-like factors research
- Supramolecular Self-Assembly in Materials
- Inflammasome and immune disorders
- Macrophage Migration Inhibitory Factor
- Animal Nutrition and Physiology
- Wnt/β-catenin signaling in development and cancer
Qingdao University
2024
Yuhuangding Hospital
2019-2024
Yunnan Agricultural University
2022-2024
Yangzhou University
2024
Anhui Medical University
2023
ZheJiang Academy of Agricultural Sciences
2022
Jilin University
2022
Tianjin University
2021
Jilin Province Tumor Hospital
2017-2021
Beijing Normal University
2020-2021
Background Zika virus (ZIKV) is an emerging flavivirus that may cause innate microcephaly or neurological disturbances. Yet no antiviral has been approved by FDA against ZIKV infection. It was shown some unsaturated fatty acids could inactivate enveloped viruses including SARS-CoV-2. However, studies investigating the effect of eicosapentaenoic acid (EPA) on infection are lacking. This study aims to evaluate EPA and other viruses. Methods We first explored toxicities in vitro vivo . Then we...
Although a plethora of nonviral gene vectors have been developed for potential therapy, imageable gemini surfactants with stimuli-responsiveness and high transfection efficiency are still scarce delivery. Herein, three amphiphiles (DEDPP-4/8/12) consisting an aggregation-induced emission (AIE) central fluorophore: 5,6-diphenylpyrazine-2,3-diester (DEDPP), decorated triazole-[12]aneN3 as the hydrophilic moiety alkyl chains various lengths hydrophobic moiety, were designed synthesized...
Abstract Vascular calcification (VC) is highly prevailing in cardiovascular disease, diabetes mellitus, and chronic kidney disease and, when present, associated with events mortality. The osteogenic differentiation of vascular smooth muscle cells (VSMCs) regarded as the foundation for mediating VC. Related transcriptional enhancer factor (RTEF-1), also named enhanced associate domain (TEAD) 4 or factor-3 (TEF-3), a nuclear potent effect on diseases, apart from its oncogenic role canonical...
This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). retracted at the request of Editor-in-Chief. An Expression Concern for this was previously published while an investigation conducted (see related editorial: https://doi.org/10.1016/j.biopha.2022.113812). retraction notice supersedes earlier. raised about reliability heart images shown in Figure 1A, which appear to contain similar features those found other...
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by abnormal synovial hyperplasia and the release of inflammatory cytokines. NLRP12 member family nod-like receptor (NLR) families that are activators inflammation. However, role in fibroblast-like synoviocytes (FLSs) still unclear. In present study, we have investigated (FLSs). The results demonstrated overexpression inhibited proliferation promoted cell apoptosis RA-FLSs. Moreover, repressed inflammation...
Rice seeds are an important energy source for humans. Seed traits difficult to observe and controlled by complex networks. Therefore, mutant libraries enriched in seed vital interpreting gene functions during development as well grain yield quality formation. Using the simple efficient genomic editing tool, several CRISPR/Cas9-based have been generated rice (Chen et al., 2022; Lu 2017; Meng 2017), other crops (Bai 2020; Jacobs Liu 2020). Genome-wide mutants some disadvantages (Gaillochet...
Background: Lysine demethylase 3A ( KDM3A ) has been increasingly recognized as an important epigenetic regulator involved in cancer development. This study aims to explore the relevance of cervical (CC) progression and molecules involved. Materials Methods: Tumor adjacent tissues from CC patients were collected. expression cell lines its correlation with survival prognosis determined. Malignant potentials cells angiogenesis ability HUVECs measured evaluate function on progression. The...
Abstract Emerging evidence suggests the important involvements of circular RNAs (circRNAs) in cancer progression. This study focuses on function Circ_0109046 malignancy endometrial carcinoma (EC) cells and molecules involved. First, high expression was found EC tissues compared to adjacent tissues, it predicted unfavorable prognosis patients. Similarly, confirmed relative that normal epithelial cells. Silencing AN3‐CA inhibited proliferation aggressiveness but increased apoptosis mainly...
Panax notoginseng is an important functional health product, and has been used worldwide because of a wide range pharmacological activities, which the taproot main edible or medicinal part. However, technologies for origin discrimination still need to be further studied. In this study, ICP-MS/MS method accurate determination 49 elements was established, whereby instrumental detection limits (LODs) were between 0.0003 7.716 mg/kg, whereas quantification (LOQs) 0.0011 25.7202 recovery in...
Hepatocellular carcinoma (HCC) accounts for a majority of primary liver cancer and is one the most common forms worldwide. Aberrant signaling FGF19-FGFR4 pathway leads to HCC in mice hypothesized be driver FGF19 amplified humans. Multiple small molecule inhibitors have been pursued as targeted therapies recent years, including several selective FGFR4 that are currently being evaluated clinical trials. Herein, we report novel series highly selective, covalent...
Introduction.The Berkeley Structural Genomics Center (BSGC) has focused on Mycoplasma as its structural genomics target organisms because of their compact genome size well relevance to human and animal pathogenicity (http://www.strgen.org). The gene for transfer RNA (m1G37) methyltransferase Aquifex aeolicus (GI number 2983865) is one the targets BSGC that been selected a homolog pneumoniae (MP) MPN183, trmD (http://www.strgen.org/status/mptargets.html). protein structures coded by either...
The developed species-specific polymerase chain reaction-lateral flow immunoassay (PCR-LFI) method allows the rapid, low-cost, highly sensitive and specific detection of donkey DNA for meat authentication, adopted by government laboratories.
Shanxi-aged vinegar, a traditional Chinese grain-fermented food that is rich in polyphenols, has been shown to have therapeutic effects on variety of diseases. However, there no comprehensive evaluation the anti-inflammatory activity polyphenols extracted from vinegar (SAVEP) date. The activities SAVEP, both RAW 264.7 macrophages and mice, were extensively investigated for potential application SAVEP as novel agent. In order confirm notion could improve inflammatory symptoms, was firstly...
The objective of this study was to investigate the effects tributyrin supplementation on liver fat metabolism in broiler chickens. Two hundred and forty broilers were randomly allocated into two experimental groups (6 replicates per treatment; 20 chickens each replicate): control group (CN), which received a basal diet, (TB), diet supplemented with 1 g/kg tributyrin. period lasted 37 days. results showed that liver, had higher content high-density lipoprotein cholesterol (HDL-C) (p < 0.05)....