Hepatitis C virus (HCV) recurrence after orthotopic liver transplantation (OLT) is universal. We aimed to evaluate the efficacy and safety of pegylated interferon (PEG-IFN) ribavirin (RIB) in treatment post-OLT HCV recurrence.Thirty-seven patients with recurrent OLT were screened began treatment. Nineteen have completed therapy. PEG-IFN was started at a dose 0.5 microg/kg per week titrated toward maximum 1.5 week. RIB 400 mg day 1000 day, as tolerated. Therapy continued for 1 year...

Patients with solid organ transplants (SOTs) have been excluded from programmed death protein-1 (PD-1)/programmed ligand-1 (PD-L1) inhibitor clinical trials due to concern for allograft rejection. The use of immune checkpoint therapy remains controversial in transplant patients.A retrospective pilot evaluation was conducted assess the safety and efficacy PD-1 inhibitors patients liver transplantation (LT). primary endpoint rate Secondary endpoints included overall response (ORR), progression...

Our aim was to determine outcomes with transplanting kidneys from deceased donors acute kidney injury, defined as a donor terminal serum creatinine ≥2.0 mg/dL, or requiring renal replacement therapy. We included all patients who received transplant June 2004 October 2013. There were 162 AKI recipients (21% of transplants): 139 in the standard criteria (SCD) and 23 expanded (ECD) cohort. 71% had stage 3 (severe AKI), based on injury network (AKIN) staging. Protocol biopsies done at 1, 4, 12...

Background and objectives: Hyperglycemia new-onset diabetes occurs frequently after kidney transplantation. The stress of surgery exposure to immunosuppression medications have metabolic effects can cause or worsen preexisting hyperglycemia. To our knowledge, hyperglycemia in the immediate posttransplantation period has not been studied. Design, setting, participants, & measurements: We conducted a retrospective, observational study characterize prevalence assess pharmacologic management...

Our aim was to study the impact of subclinical inflammation on development interstitial fibrosis and tubular atrophy (IF/TA) a 1-year protocol biopsy in patients rapid steroid withdrawal (RSW). A total 256 were classified based findings at months 1 or 4. Group is 172 with no inflammation, group 2 50 (SCI), 3 19 acute rejection (SAR) 4 15 clinical (CAR). On biopsy, more (SCI) (34%, p = 0.004) (53%, 0.0002), had an IF/TA score > compared (control) (15%). not increased (CAR) (20%). The percent...

Approximately two-thirds of kidney transplant recipients with no previous history diabetes experience inpatient hyperglycemia immediately after surgery; whether predicts future new onset (NODAT) is not established.A retrospective study was conducted to determine the risk conferred by on development NODAT within 1 year posttransplant. All adult nondiabetic between June 1999 and January 2008 were included. Posttransplant defined as any bedside capillary blood glucose > or = 200 mg/dl insulin...

As the population in United States continues to age, an increase number of potential donation after circulatory death (DCD) donors with advanced chronological age can be expected. The aim this study was analyze a multi-institutional experience liver transplantation using DCD 50 years or older.All transplant (LT) performed at Mayo Clinic Florida, Rochester, and Arizona from 2002 2016 were included. Recipients LT divided into 2 groups: those older (N = 155) younger than years(N 316).Graft...

There is controversy regarding the impact of delayed graft function (DGF) on kidney transplant outcomes. We hypothesize that duration DGF, rather than DGF itself, associated with long-term function.We analyzed all deceased donor transplants (DDKT) done at our center between 2008 to 2020. determined factors duration. was assessed three 14-day intervals: < 14 days, 14-27 > 28 days. studied survival and resource utilization, including hospital length stay readmissions.1714 DDKT recipients were...

CT has made it possible to determine the contour of pancreatic duct, measure its caliber, and detect dilatation duct. scans 75 patients with carcinoma 45 chronic pancreatitis were obtained. Dilatation duct was seen in 56% carcinoma, 70% those tumors confined head body. Smooth (43%) or beaded (40%) most commonly associated carcinoma. Ductal present 58% pancreatitis, irregular 73% this group. About half who had calculi within ducts. The similar that 27% cases pancreatitis. There a significant...

OBJECTIVE New-onset diabetes after kidney transplantation (NODAT) has adverse clinical and economic implications. A risk score for NODAT could help identify research subjects intervention studies. RESEARCH DESIGN AND METHODS We conducted a single-center retrospective cohort study using pretransplant laboratory measurements to construct NODAT. was defined by hemoglobin A1c (HbA1c) ≥6.5%, fasting serum glucose ≥126 mg/dL, or prescribed therapy within 1 year posttransplant. Three multivariate...

Brief Reports1 January 1980Fanconi's Syndrome and Distal Renal Tubular Acidosis After Glue SniffingALVlN H. MOSS, M.D., PATRICIA A. GABOW, WILLIAM D. KAEHNY, STEPHEN I. GOODMAN, LEWIS L. HAUT, MARK R. HAUSSLER, Ph.D.ALVlN Ph.D.Author, Article, Disclosure Informationhttps://doi.org/10.7326/0003-4819-92-1-69 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptGlue, paint, or toluene sniffers may develop signs of...

Millions of Americans regularly use herbal supplements, but many are unaware the potential hidden dangers. Numerous supplements have been associated with hepatotoxicity and, indeed dietary/herbal represent an increasingly common source acute liver injury. We report a case failure requiring transplantation Garcinia cambogia, supplement widely promoted for weight loss. When patients present hepatitis or from unknown etiology, careful history should be performed.

Kidneys from deceased donors with acute kidney injury (AKI) are more likely to be discarded because of concerns for poor outcomes after transplantation. The aim this study was determine the long-term a large cohort patients transplanted utilizing kidneys AKI.All receiving donor transplant during recent 10-year period were included. Acute Kidney Injury Network (AKIN) criteria used classify donors. Donor >10% cortical necrosis or than mild chronic changes discarded. primary outcome is combined...

BackgroundGiven the potentially additive risk from using donor livers that are both steatotic and a donation after circulatory death (DCD) donor, there is paucity of data on outcome DCD liver transplantation (LT) utilizing with macrosteatosis.MethodsAll LT performed at Mayo Clinic-Florida, Clinic-Arizona, Clinic-Rochester 1999 to 2019 were included (N = 714). Recipients divided into 3 groups: those moderate macrosteatosis (30%-60%), mild (5%-30%), no steatosis (<5%).ResultsPatients had...

Pre-emptive kidney transplants have not been favored in some centers because of concern about possible increased noncompliance and allegedly inferior long-term results. We analyzed our experience with pre-emptive to determine whether such concerns are justified.Between January 1, 1984, June 30, 1998, we performed 1849 adult primary transplants: 385 (recipients undergoing dialysis, ND) 1464 non-pre-emptive D). Results were subdivided by donor source: cadaver (CAD) living (LD). ND recipients...

ALMOND, P. S.; GILLINGHAM, K. J.; SIBLEY, R.; MOSS, A.; MELIN, M.; LEVENTHAL, MANIVEL, C.; KYRIAKIDES, P.; PAYNE, W. D.; DUNN, D. L.; SUTHERLAND, E. GORES, F.; NAJARIAN, J. MATAS, A. Author Information

Cardiovascular disease (CVD) is a leading cause of post–liver transplant death, and variable care patterns may affect outcomes. We aimed to describe epidemiology outcomes inpatient CVD across US hospitals. Using merged data set from the 2002‐2011 Nationwide Inpatient Sample American Hospital Association Annual Survey, we evaluated liver patients admitted primarily with myocardial infarction (MI), stroke (cerebrovascular accident [CVA]), congestive heart failure (CHF), dysrhythmias, cardiac...

Noninvasive biomarker profiles of acute rejection (AR) could affect the management liver transplant (LT) recipients. Peripheral blood was collected following LT for discovery (Northwestern University [NU]) and validation (National Institute Allergy Infectious Diseases Clinical Trials in Organ Transplantation [CTOT]-14 study). Blood gene profiling paired with biopsies showing AR or ADNR (acute dysfunction no rejection) as well stable graft function samples (Transplant eXcellent-TX). CTOT-14...

Abstract Kidney transplant (KT) outcomes from high kidney donor profile index (KDPI ≥85%) donors with acute injury (AKI) remain underreported. KT 172 KDPI Acute Injury Network (AKIN) stage 0‐1 and 76 AKIN 2‐3 a single center were retrospectively assessed. The cohort had more delayed graft function (71% vs. 37%, p &lt; .001). At one year, there no differences in the estimated glomerular filtration rate (44 ± 17 46 18, = .42) or fibrosis on protocol biopsy (ci, .85). Donor terminal creatinine...

Sixty-one consecutive patients suspected of having pancreatic neoplasms had endoscopic retrograde cholangiopancreatography (ERCP) and computed tomography (CT). The ERCP results were 62% accurate, 8% false negative, 3% failure. overall accuracy in cases successful duct cannulation was 88%. CT 76% correct, 5% positive, 13% 6% indeterminate. Excluding failure, the CT-ERCP diagnosis identical 67%. When findings identical, rate 93%, high than that either study alone. ERCP-CT examinations often...