During the last few years, there has been an extraordinary increase in publications describing manifold applications of monoolein, one most important lipids fields drug delivery, emulsion stabilization and protein crystallization. In this perspective we present a comprehensive review phase behavior 'magic lipid'. An account various mesophases formed presence water collection formulae for calculation their nano-structural parameters are provided. Effects chemical biological molecules...

Many amphiphile–water mixtures will self-assemble into three-dimensional soft condensed structures known as inverse bicontinuous cubic phases. These are found in nature and have applications nanotechnology. Here we show that by systematically varying amphiphile chain splay, able to control the relative stability of phases a homologous series monoglycerides predictable manner. In particular, demonstrate decreasing splay leads appearance primitive phase while increasing reduces channel size...

Three-dimensionally organized lipid cubic self-assemblies and derived oil-in-water emulsions called "cubosomes" are attractive for various biotechnological applications due to their ability be loaded with functional molecules associated sustained release properties. Here, we employed both of these lipid-based systems the delivery a model drug, aspirin, under comparable conditions. Studies were performed by varying drug-to-lipid ratio type medium, water phosphate buffer saline (PBS). Release...

In recent years, lipid based nanostructures have increasingly been used as model membranes to study various complex biological processes. For better understanding of such phenomena, it is essential gain much information possible for structures under physiological conditions. this paper, we focus on one lipids--monoelaidin (ME)--for its polymorphic varying conditions temperature and water content. the contribution (Soft Matter, 2010, 6, 3191), reported phase diagram ME above 30 °C compared...

A majority of cosmetic products that we encounter on daily basis contain lipid constituents in solubilized or insolubilized forms. Due to their amphiphilic nature, the molecules spontaneously self-assemble into a remarkable range nanostructures when mixed with water. This review illustrates formation and finely tunable properties self-assembled hierarchically organized derivatives, as well relevance development formulations. These systems can be modulated various physical forms suitable for...

Bile salts (BSs) are important for the digestion and absorption of fats fat-soluble vitamins in small intestine. In this work, we scrutinized, with small-angle X-ray scattering (SAXS), crucial functions bile beyond their capacity interfacial stabilization submicrometer-sized lipid particles. By studying a wide compositional range BS-lipid dispersions using two widely applied lipids drug-delivery systems (one monoglyceride being stabilizer-sensitive other an aliphatic alcohol relatively...

We present novel water-in-oil (W/O) emulsions with a nanostructured oil phase that resemble soft materials such as creams, pastes and spreadable used in cosmetics, pharma food applications. These have broad structural hierarchy involves 50 to 90 volume percent of micron sized water droplets (2–50 µm) confined by continuous hydrophobic film itself is made lyotropic nanostructure. This nanostructure can be modulated into inverse bicontinuous cubic, micellar hexagonal or microemulsion phases....

We characterize a recently introduced novel nanobilayer technique [Gornall, J. L., Mahendran, K. R., Pambos, O. J., Steinbock, L. Otto, O., Chimerel, C., Winterhalter, M., and Keyser, U. F. Simple reconstitution of protein pores in nano lipid bilayers. Nano Lett. 2011, 11 (8), 3334-3340] its practical aspects for incorporating the biological nanopore α-hemolysin from Staphylococcus aureus subsequent studies on translocation biomolecules under various conditions. This provides advantages over...

We present the first report on effects of hydrostatic pressure colloidally stabilized lipid nanoparticles enveloping inverse nonlamellar self-assemblies in their interiors. These internal were systematically tuned into bicontinuous cubic (Pn3m and Im3m), micellar (Fd3m), hexagonal (H2), (L2) phases by regulating lipid/oil ratio as was varied from atmospheric to 1200 bar back pressure. The these compared with those equilibrium bulk, nondispersed counterparts, namely, liquid-crystalline...

Lipid-based equilibrium self-assemblies and their hierarchically ordered forms have been known since the last few decades. Related progress in colloids interface science led development of oil-in-water type internally self-assembled lipid particles, as Isasomes, which aroused great interest biotechnological applications. These submicrometer-sized particles are nanostructured a form various liquid-crystalline or microemulsion phases, facilitate loading with hydrophilic, hydrophobic,...

Carbon nanotubes (CNTs) are increasingly studied for innovative biotechnological applications particularly where they combined with essential biological materials like lipids. Lipids have been used earlier enhancing the dispersibility of CNTs in aqueous solutions. Here we report a novel application stabilization internally self-assembled nanostructured lipid particles 2-5 μm size. Single-walled (pristine) as well -OH and -COOH functionalized multi-walled were employed to produce emulsions...

We present a facile method to prepare nanostructured lipid particles stabilized by carbon nanotubes (CNTs). Single-walled (pristine) and multi-walled (functionalized) CNTs are used as stabilizers produce Pickering type oil-in-water (O/W) emulsions. Lipids namely, Dimodan U Phytantriol emulsifiers, which in excess water self-assemble into the bicontinuous cubic Pn3m phase. This highly viscous phase is fragmented smaller using probe ultrasonicator presence of conventional surfactant or done...

The membrane protein bacteriorhodopsin (bR) can be reconstituted into the of lipid 1-monoolein (MO). This forms a lyotropic liquid crystalline phase whose has hyperbolic interfacial curvature. Using optical absorption spectroscopy and small angle X-ray scattering we have observed retinal unbinding from bR that is correlated with degree evidence suggests susceptible to induced saddle splay for modest perturbations equilibrium, but more extreme distortions becomes stiff resists