A5087992218- Peptidase Inhibition and Analysis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Ubiquitin and proteasome pathways
- Cancer Research and Treatments
- Pediatric Hepatobiliary Diseases and Treatments
- Cancer Mechanisms and Therapy
- Cancer-related gene regulation
- Pancreatic and Hepatic Oncology Research
- Advanced biosensing and bioanalysis techniques
- Liver Disease and Transplantation
- Liver Diseases and Immunity
- MicroRNA in disease regulation
- Protease and Inhibitor Mechanisms
- Metal complexes synthesis and properties
- Prostate Cancer Treatment and Research
- Cancer Immunotherapy and Biomarkers
- Cancer, Hypoxia, and Metabolism
University of the Basque Country
2020-2025
Biogipuzkoa Health Research Institute
2020-2025
Inflammation, particularly that mediated by bacterial components translocating from the gut to liver and binding toll-like receptors (TLRs), is central cholestatic injury. The triggering receptor expressed on myeloid cells-2 (TREM-2) inhibits TLR-mediated signaling exerts a protective role in hepatocellular injury carcinogenesis. This study aims evaluate of TREM-2 cholestasis.
Background and Rationale: Cholangiocarcinoma (CCA) includes a diverse group of biliary malignancies with poor prognosis. Alterations in post-translational modifications contribute to disrupted protein dynamics, cellular disturbances, disease. This study investigates the role SUMOylation cholangiocarcinogenesis its potential as therapeutic target. Approach Results: Analysis CCA tumors from four patient cohorts cell lines, revealed increased expression machinery genes SAE1 UBE2I , regardless...
Cholangiocarcinoma (CCA) comprises a heterogeneous group of malignant tumors associated with dismal prognosis. Alterations in post-translational modifications (PTMs), including NEDDylation, result abnormal protein dynamics, cell disturbances and disease. Herein, we investigate the role NEDDylation CCA development progression.Levels functions together response to pevonedistat (NEDDylation inhibitor) or CRISPR/Cas9 against NAE1 were evaluated vitro, vivo and/or patients CCA. The preneoplastic...