A5056394925- Dementia and Cognitive Impairment Research
- Functional Brain Connectivity Studies
- Alzheimer's disease research and treatments
- Health, Environment, Cognitive Aging
- Nutrition and Health in Aging
- Frailty in Older Adults
- Nutritional Studies and Diet
- Cognitive Abilities and Testing
- Advanced Neuroimaging Techniques and Applications
- Health disparities and outcomes
- Personality Traits and Psychology
- Attention Deficit Hyperactivity Disorder
- Orthopaedic implants and arthroplasty
- Bone Tissue Engineering Materials
- Behavioral Health and Interventions
- Counseling Practices and Supervision
- Cancer-related cognitive impairment studies
- Psychosomatic Disorders and Their Treatments
- Blood Pressure and Hypertension Studies
- Identity, Memory, and Therapy
- Sensory Analysis and Statistical Methods
- Titanium Alloys Microstructure and Properties
- Antioxidant Activity and Oxidative Stress
- Psychological Testing and Assessment
- Neurobiology of Language and Bilingualism
Massachusetts General Hospital
2023-2024
Brigham and Women's Hospital
2023-2024
Harvard University
2022-2024
University of Georgia
2018-2022
Franklin College
2018
University of Wisconsin–Madison
1998
Arizona State University
1995
Lutein (L) and zeaxanthin (Z) are two xanthophyll carotenoids that have antioxidant anti-inflammatory properties. Previous work has demonstrated their importance for eye health preventing diseases such as age-related macular degeneration. An emerging literature base also the of L Z in cognition, neural structure, efficiency. The present study aimed to better understand mechanisms by which relate particular, visual–spatial processing decision-making older adults. We hypothesized markers...
Self-reported cognitive decline is an early behavioral manifestation of Alzheimer disease (AD) at the preclinical stage, often believed to precede concerns reported by a study partner. Previous work shows cross-sectional associations with β-amyloid (Aβ) status and self-reported partner-reported decline, but less known about their tau deposition, particularly among those AD.
The influence of maximal exercise testing on state anxiety was examined in three separate studies. Highly trained male distance runners (Study 1, n = 12) as well college students with average 2, 16) and below 3, 32) physical fitness levels completed graded tests. This last group also randomly assigned to either a control or an 8 week training programme order determine the effect increased psychological responses testing. Physical determined by measurement oxygen uptake. State (State-Trait...
Given that black American older adults are more likely to have lower educational attainment and perform worse on cognitive tests than white Americans, we examined whether increased education would confer greater advantage Americans measures of global specific domains function. The sample included 522 community-dwelling from a larger study. An analysis covariance was conducted with race as between-participant factors cognition the dependent variable. A multivariate five (immediate memory,...
Objectives This study evaluated the role of personality in predicting functional ability (FA) older adults using self-report, collateral report, and performance-based measures FA.Methods Participants included (N = 131) who completed a measure (NEO-FFI), self-report FA (OARS ADL), participated assessment (DAFS-R). In addition, each participant had complete report ADL). Bivariate correlations were computed to assess how Five Factor Model traits related collateral, FA.Results Neuroticism was...
The population of older adults is increasing, indicating a need to examine factors that may prevent or mitigate age-related cognitive decline. current study examined whether microstructural white matter characteristics mediated the relation between physical activity and executive function in without any self-reported psychiatric neurological disorders impairment (N = 43, mean age 73 y). Physical was measured by average intensity number steps via accelerometry. Diffusion tensor imaging used...
Abstract INTRODUCTION The associations between subjective cognitive decline (SCD), cognition, and amyloid were explored across diverse participants in the A4 study. METHODS Five thousand one hundred fifty‐one non‐Hispanic White, 262 Black, 179 Hispanic‐White, 225 Asian completed Preclinical Alzheimer Cognitive Composite (PACC), self‐ study partner‐reported Function Index (CFI). A subsample underwent positron emission tomography ( 18 F‐florbetapir) N = 4384). We examined self‐reported CFI,...
Recent evidence suggests that physical activity may influence the functional connectivity of aging brain. The purpose this study was to examine on association between executive function and key brain networks graph theory metrics in community-dwelling older adults. Participants were 47 adults (M = 73 years; SD 5.92) who participated neuropsychological testing, measurements, magnetic resonance imaging (MRI). Seed-to-voxel moderation analyses conducted. Physical significantly positively...
Abstract Background PET quantifies tau and amyloid‐ß (Aß) pathology in preclinical AD. A 2‐min digital clock‐drawing test ( DCTclock TM ) captures outcomes processes, potentially more sensitive to cognitive deficits AD than pencil‐and‐paper tests. The summary score comprised subscores targeting multi‐domain performance (i.e., Drawing Efficiency, Information Processing, Spatial Reasoning, Simple Motor). These included unique features reflecting hesitation (pen‐stroke latencies) speed during...
Abstract Background Family history (FH) of AD increases risk for sporadic AD, and has been associated with increased amyloid accumulation. Most these studies were done in non‐Hispanic white groups, limiting the generalizability findings. The goal this study was to determine if FH levels White, Black, Hispanic/Latino participants. Methods This included cognitively normal individuals screening Anti‐Amyloid Treatment Asymptomatic Alzheimer’s (A4) cohort whom self‐identified as...
Objectives: The current study sought to evaluate the relationship between cognitive performance and Instrumental Activities of Daily Living (IADL) in a population community dwelling older adults, assess what extent this is moderated by reserve (Premorbid-IQ)Methods: 123 community-dwelling adults completed general assessment, word-reading based premorbid-IQ estimate (PMIQE) measure, performance-based Direct Assessment Functional Status, Revised (DAFS-R). Moderated regression analysis was used...
Understanding sex differences when assessing personality in older adults is important for researchers and clinicians. The current study utilized differential item functioning (DIF) to compare male female adults’ responses on the NEO-FFI detect potential sources of measurement bias. Participants included 244 (98 males, 146 females, mean age = 73). DIF by was determined using ordinal logistic regression response theory.Non-uniform present 31, uniform 26 Neuroticism scale. In Extraversion...
Objective: In the current study we seek to determine if frailty moderates relationship between cognitive reserve and function in a sample of community dwelling older adults.Identifying components their with functional outcomes is major focus clinical practice aging research, as status has implications for health outcomes.We proposed that would moderate positive such at higher levels protective effects on performance are diminished.Method: The consisted 73 community-dwelling adults (age...
Objective: 1) Evaluate the association of self- and study-partner report subjective cognitive decline (SCD) to objective performance across ethnoracial groups. 2) concordance study partner SCD Participants Methods: were 5241 non-Hispanic White (NHW), 267 Black (NHB), 225 Hispanic, 228 Asian participants screened for A4 (N=5961). completed Preclinical Alzheimer Cognitive Composite (PACC), partner-report using Function Index (CFI). Analysis variance was used assess difference in key variables...
Objective: White matter microstructure (WMM) potentially mediates the relation between APOE4 and memory performance. This study’s purpose was to understand whether p-tau effects this mediation model education level differentially impacts relations these genetic biological biomarkers’ influence on memory. Participants Methods: included 161 older adults (M=74 years, 40.4% female, 92% White, 74 e4 non-carriers, 87 carriers) with subjective objective cognitive impairment from Alzheimer’s Disease...
Abstract Background Digital cognitive tools may provide unique opportunities to detect subtle changes in preclinical Alzheimer’s disease (AD). Here, a maze test using digital pen was evaluated relation AD pathological measured by amyloid‐β and tau burden. Method 172 participants (CN = 161, MCI 6, dementia 5) completed the test, which included multiple “no‐choice” (NC; i.e., no decisions required complete maze) or “choice” (CH) conditions (i.e., problem‐solving maze). Maze composite scores...