A5032889479- Dementia and Cognitive Impairment Research
- Functional Brain Connectivity Studies
- Health, Environment, Cognitive Aging
- Health disparities and outcomes
- Cardiovascular Health and Disease Prevention
- Blood Pressure and Hypertension Studies
- Nutrition and Health in Aging
- Retinal Development and Disorders
- Nerve injury and regeneration
- Alzheimer's disease research and treatments
- Frailty in Older Adults
- Heart Rate Variability and Autonomic Control
- Adipose Tissue and Metabolism
- Advanced Neuroimaging Techniques and Applications
- Visual perception and processing mechanisms
- Cardiovascular Disease and Adiposity
- Personality Traits and Psychology
- EEG and Brain-Computer Interfaces
- Biochemical effects in animals
- Neural and Behavioral Psychology Studies
- Sleep and related disorders
- Urban and spatial planning
- Neurosurgical Procedures and Complications
- Neurogenesis and neuroplasticity mechanisms
- Psychological Testing and Assessment
University of Pittsburgh Medical Center
2024-2025
University of Pittsburgh
2024-2025
Vanderbilt University Medical Center
2022-2024
Vanderbilt University
2023
Aarhus University
2022
Herlev Hospital
2022
University of Georgia
2018-2022
Emory University
2014-2018
Atlanta VA Medical Center
2015-2018
Franklin College
2018
ABSTRACT Background Higher cardiorespiratory fitness and cardiovascular endurance (CE) have been shown to be neuroprotective in older adulthood, but the mechanisms underlying this neuroprotection across adult lifespan are poorly understood. The current study sought examine effects of CRF on gray matter (GM) white (WM) volumes, mean cortical thickness (MCT), using a large sample lifespan. We also examined sex differences these relationships. Methods This cross‐sectional included data from...
Aerobic exercise is a common intervention for rehabilitation of motor, and more recently, cognitive function (Intlekofer Cotman, 2013; Wood et al., 2012). While the underlying mechanisms are complex, BDNF may mediate much beneficial effects to these neurons (Ploughman 2007; Griffin 2011; Real 2013). We studied aerobic on retinal undergoing degeneration. exercised wild-type BALB/c mice treadmill (10 m/min 1 h) 5 d/week or placed control static treadmills. After 2 weeks exercise, were exposed...
Purpose: Our previous investigations showed that involuntary treadmill exercise is neuroprotective in a light-induced retinal degeneration mouse model, and it may act through activation of tropomyosin-related kinase B (TrkB) receptors. This study investigated whether voluntary running wheel can be an inheritable model the degenerative disease retinitis pigmentosa (RP), rd10 mice. Methods: Breeding pairs C57BL/6J mice were given free-spinning (active) or locked (inactive) wheels. Pups weaned...
Abstract Diabetic retinopathy is a leading cause of vision loss. Treatment options for early are sparse. Exercise protects dying photoreceptors in models retinal degeneration, thereby preserving vision. We tested the protective effects exercise on and cognitive deficits type 1 diabetes model determined whether TrkB pathway mediates this effect. Hyperglycaemia was induced Long Evans rats via streptozotocin injection ( STZ ; 100 mg/kg). Following confirmed hyperglycaemia, both control diabetic...
Lutein (L) and zeaxanthin (Z) are two xanthophyll carotenoids that have antioxidant anti-inflammatory properties. Previous work has demonstrated their importance for eye health preventing diseases such as age-related macular degeneration. An emerging literature base also the of L Z in cognition, neural structure, efficiency. The present study aimed to better understand mechanisms by which relate particular, visual–spatial processing decision-making older adults. We hypothesized markers...
Given that black American older adults are more likely to have lower educational attainment and perform worse on cognitive tests than white Americans, we examined whether increased education would confer greater advantage Americans measures of global specific domains function. The sample included 522 community-dwelling from a larger study. An analysis covariance was conducted with race as between-participant factors cognition the dependent variable. A multivariate five (immediate memory,...
Background An Alzheimer's Association (AA) workgroup published criteria for the diagnosis and staging of disease (AD). To date, there have not been empirical investigations professionals’ opinions regarding AA AD. Objective Our goal was to survey clinical neuropsychologists with expertise in dementia about these criteria. Methods Participants were recruited from a professional interest group focused on dementia. They rated their agreement 15 statements draft AD prior publication final...
Objectives This study evaluated the role of personality in predicting functional ability (FA) older adults using self-report, collateral report, and performance-based measures FA.Methods Participants included (N = 131) who completed a measure (NEO-FFI), self-report FA (OARS ADL), participated assessment (DAFS-R). In addition, each participant had complete report ADL). Bivariate correlations were computed to assess how Five Factor Model traits related collateral, FA.Results Neuroticism was...
The population of older adults is increasing, indicating a need to examine factors that may prevent or mitigate age-related cognitive decline. current study examined whether microstructural white matter characteristics mediated the relation between physical activity and executive function in without any self-reported psychiatric neurological disorders impairment (N = 43, mean age 73 y). Physical was measured by average intensity number steps via accelerometry. Diffusion tensor imaging used...
Recent evidence suggests that physical activity may influence the functional connectivity of aging brain. The purpose this study was to examine on association between executive function and key brain networks graph theory metrics in community-dwelling older adults. Participants were 47 adults (M = 73 years; SD 5.92) who participated neuropsychological testing, measurements, magnetic resonance imaging (MRI). Seed-to-voxel moderation analyses conducted. Physical significantly positively...
Background The relationship between subtle cognitive decline and Alzheimer's disease (AD) pathology as measured by biomarkers in settings outside of specialty memory clinics is not well characterized. Objective To investigate how longitudinal relates to neuroimaging individuals drawn from a population-based study an economically depressed, small-town area southwestern Pennsylvania, USA. Methods A subset participants without dementia (N = 115, age 76.53 years ± 6.25) the Monongahela...
Abstract Background Socioeconomic neighborhood disadvantage has been linked to accelerated biological aging, cognitive decline, and core Alzheimer’s disease neuropathology independent of individual‐level factors. Our recent work indicates is also implicated in cerebrovascular changes known exacerbate the development AD, including neurovascular hemodynamic dysfunction. Here, we investigated how relates microstructural white matter, a sensitive biomarker for emerging related neurodegeneration....
Abstract Background Neighborhood walkability may affect cognitive impairment through promotion of physical activity. However, most studies are conducted in urban, predominantly White samples. We assessed how is related to presence and whether the relation differs by neighborhood population density (differences likelihood promoting activity) and/or racial composition quality resources). hypothesized that lower greater having this association stronger areas with higher (i.e., more urban) a...
This commentary focuses on the clinical utility of plasma amyloid-β (Aβ) 42/40 to detect semantic intrusion errors in amnestic mild cognitive impairment, as investigated Curiel Cid et al. a recent issue Journal Alzheimer's Disease. highlights importance testing sensitivity Aβ symptoms quest develop comprehensive definition AD that incorporates both biological precursors and consequences.