A5001010122- Sepsis Diagnosis and Treatment
- Hemodynamic Monitoring and Therapy
- Renal function and acid-base balance
- Public Health and Nutrition
- Respiratory Support and Mechanisms
- Cardiac Arrest and Resuscitation
- Neonatal and Maternal Infections
- COVID-19 Impact on Reproduction
- Methodologies in Health Research and Practice
- Cardiac, Anesthesia and Surgical Outcomes
- Non-Invasive Vital Sign Monitoring
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Traumatic Brain Injury and Neurovascular Disturbances
- COVID-19 Clinical Research Studies
- Electrolyte and hormonal disorders
- Acute Kidney Injury Research
- Emergency and Acute Care Studies
- Adrenal Hormones and Disorders
- Infant Development and Preterm Care
- Inflammation biomarkers and pathways
- Malaria Research and Control
- Pediatric Hepatobiliary Diseases and Treatments
- Intensive Care Unit Cognitive Disorders
- Cardiovascular Health and Disease Prevention
- Liver Disease and Transplantation
Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo
2014-2024
University of Indonesia
2014-2024
Creative Commons
2023
Indonesian Pediatric Society
2021-2022
Institute of Child Health
2021
University of North Sumatra
2020
IPB University
2020
Universitas Gadjah Mada
2019
Udayana University
2013
Riau University
2010
BackgroundThe incidence of coronavirus disease 2019 (COVID-19) is still increasing rapidly, but little known about the prevalence and characteristics fatal cases in children Indonesia. This study aimed to describe with COVID-19 outcomes a tertiary referral hospital Indonesia.MethodsThis cross-sectional used data collected from medical records patients admitted Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia March October 2020.ResultsDuring period, 490 were diagnosed suspected probable...
Cardiopulmonary bypass in tetralogy of Fallot (TOF) corrective surgery induces hyperinflammation by activating NLRP3, caspase-1, and interleukin-1β (IL-1β), subsequently triggering an interleukin-10 (IL-10) response. Despite its known metabolic anti-inflammatory effects, the impact modified Atkins diet (MAD) pediatric cardiac remains unexplored, with no studies on use TOF patients undergoing open-heart surgery. The aim this study was to assess effect MAD expression IL-1β, IL-10, A...
Background: Indonesia has a high number of COVID-19 cases and mortalities relative to not only among the Asia Pacific region but world. Children were thought be less affected by virus compared adults. Most public data reported combined between adults children. The Indonesian Pediatric Society (IPS) was involved in response, especially area child health. One IPS's activities is collecting registries from each their chapters provide better understanding Objective: objective this study share...
Fluid challenge is often used to predict fluid responsiveness in critically ill patients. Inappropriate expansion can lead some unwanted side effects; therefore, we need a noninvasive predictive parameter assess responsiveness. We want the hemodynamic changes after passive leg raising, which mimic expansion, pediatric intensive care unit patients and get cutoff value of cardiac index predicting patients.Nonrandomized experimental study.Tertiary academic care.Children admitted...
Latar belakang. Sepsis merupakan penyebab utama kematian bayi dan anak. Status imun pejamu malnutrisi faktor penting yang menentukan luaran pada sepsis. Skor pediatric logistic organ dysfunction (PELOD) adalah sistem skoring disfungsi sakit kritis, untuk memprediksi mortalitas pasien sepsis.Tujuan. Mengetahui risiko usia, status gizi, skor PELOD terhadap sepsis.Metode. Retrospektif analitik berupa data rekam medis berusia 1 bulan – 18 tahun di PICU RSCM Apri1- Agustus 2011 dengan diagnosis...
Abstract Background High-flow nasal cannula (HFNC) is often used in pediatric populations with respiratory distress. In adults, the respiratory-rate oxygenation (ROX) index as a predictor of HFNC therapy; however, children have age-associated differences rate, thus may not be applicable to children. This study aims find reliability ROX and modified P-ROX predictors therapy failure patients. Methods Subjects this analytical cross-sectional were taken from January 2023 until November Cipto...
Purpose: Peroxisome proliferator-activated receptor gamma (PPAR-γ) has a key role in hepatic fibrogenesis by virtue of its effect on the stellate cells (HSCs).Although many studies have shown that PPAR-γ agonists inhibit liver fibrosis, mechanism remains largely unclear, especially regarding cross-talk between and other potent fibrogenic factors.Methods: This experimental study involved 25 male Wistar rats.Twenty rats were subjected to bile duct ligation (BDL) induce further divided into an...
While the number of cases multisystem inflammatory syndrome in children (MIS-C) is increasing, reported Asian countries are still low, particularly Indonesia. This study aimed to describe characteristics patients with MIS-C a tertiary referral hospital Indonesia.This cross-sectional collected data admitted Dr. Cipto Mangunkusumo from March 2020 April 2021.The first case was detected 5 months after coronavirus disease 2019 Thirteen out 158 positive for COVID-19 were diagnosed during period....
Latar belakang. Infeksi luka operasi (ILO) merupakan salah satu komplikasi pasca-bedah abdomen yang dapat meningkatkan morbiditas, mortalitas, dan biaya pengobatan. Diperlukan data prevalens ILO pada anak di RSCM faktor risiko memengaruhinya.Tujuan. Mengetahui karakteristik serta hubungan antara usia, jenis kelamin, status nutrisi, skor PELOD, ASA, operasi, kategori lama dengan anak.Metode. Data penelitian dari rekam medis tahun 2009-2011 besar sampel 180 subjek. Analisis statistik uji...
Mortality in pediatric septic shock remains very high. Vasoactive-inotropic score (VIS) is widely used to predict prognosis patients with heart disease. It a simple method that was initially as predictor of morbidity and mortality postoperative congenital diseases. Previous reports showed high VIS associated sepsis. However, its discriminative value unclear. We aim explore the predicting patients.We conducted retrospective cohort study on medical records who received care intensive unit...
All sectors are affected due to COVID-19 pandemic occurring worldwide, including the education industry. School closure had been taking place for more than a year in Indonesia. Despite controversies, Indonesian government decided begin school reopening.This study aims assess parental readiness reopening, and factors affecting attitude toward reopening.A cross-sectional using online questionnaire distributed via official Pediatric Society (IPS) social media account collected between March...
Latar belakang. Berdasarkan berbagai penelitian, diperlukan skala nyeri yang divalidasi untuk menilai di ruang perawatan intensif anak dari aspek respon otonom dan evaluasi bentuk intervensi tata laksana diberikan.Tujuan. Mengetahui validitas alat pengukur non verbal pain scale (NVPS) dapat dipakai anak.Metode. Subyek penelitian diberikan melalui prosedur pemeriksaan atau terapi, dinilai perekaman video. Respon selama 2-10 menit sebelum, selama, setelah diberikan. Sebagai baku emas digunakan...
We aimed to determine the correlations of human Atrial Natriuretic Peptide (ANP) on cardiac function and hemodynamics in pediatric septic shock.We conducted an observational prospective study 30 children with shock. Measurement level atrial natriuretic peptide was determined serum patients. Cardiac power (CP) is a parameter measured output (cardiovascular flow) mean arterial (intravascular) pressure. pressure were monitored using recording analytical methods (PRAM). Hemodynamic status...
Hypoganglionosis resembles Hirschsprung's disease as in both diseases, patients may present with severe constipation or pseudo-obstruction. To date, diagnosis of hypoganglionosis is still difficult to be established due lack international consensus regarding diagnostic criteria. This study aims evaluate the use immunohistochemistry provide objective support for our initial subjective impression well describe morphological features this study.This a cross-sectional study. Three resected...
Background The asynchrony rapid phase of cognitive, physical and emotional development occurring in adolescence may result various issues such as risk-taking behavior, psychosocial problems. School closure during the COVID-19 pandemic has caused a tremendous change adolescent lifestyle habits, including sleep patterns. causing added challenges to adolescents’ behavioral problems.
 Objective To identify association between disorders with problems urban rural adolescents.
 Methods We...
Background: Increased capillary permeability in sepsis is associated with several complications and worse outcomes. Glycocalyx degradation, marked by increased serum syndecan-1 levels, alters vascular permeability, which can manifest as albuminuria the glomerulus. Therefore, elevated urinary albumin to creatinine ratio (ACR) potentially provides an index of systemic glycocalyx degradation. The aim this study was analyze correlation between ACR levels.Methods: A longitudinal prospective...
Background According to the most recent Sepsis-3 Consensus, definition of sepsis is life-threatening organ dysfunction caused by dysregulated immune system against infection. Currently, one commonly used prognostic scoring pediatric logistic damage-2 (PELOD-2) score.
 Objective To determine and validate dysfunction-2 cut-off score predict mortality in patients.
 Methods A prospective cohort study was conducted intensive care units Cipto Mangunkusumo Hospital, Jakarta. We assessed...
Acute phase protein plasminogen activator inhibitor type-1 (PAI-1) is a key element in fibrinolysis inhibition sepsis-induced disseminated intravascular coagulation (DIC). Elevated PAI-1 level related to worse outcome sepsis. The aim of this study was investigate the relationship between plasma and clinical children with A total 35 sepsis were enrolled into prospective study. Plasma measured on day-1 day-4. Systemic profile Individuals followed up until 28 days. mean from day-4 overt DIC not...
Latar belakang. Pada sindrom syok dengue (SSD) dapat terjadi iskemia usus yang menyebabkangangguan gut barrier sehingga translokasi bakteri dan produknya (endotoksin) ke dalam sirkulasisistemik. Di Indonesia, terdapat beberapa pemeriksaan laboratorium tersedia untuk mendeteksi infeksibakteri antara lain procalcitonin (PCT), CRP, hitung leukosit, biakan bakteri, sedangkan pemeriksaanneoptrin endotoksin belum secara komersial. Biakan darah memerlukan waktu lama dandapat memperburuk prognosis...
Mild elevation of serum amino-terminal pro-B-type natriuretic peptide (NT-pro-BNP) is associated with myocardial dysfunction. A significantly lower Smith-Madigan inotropic index (SMII) has been shown to accurately represent cardiac contractility among heart failure subjects. We aim monitor the effect fluid resuscitation on function paediatric patients by measuring NT-pro-BNP and SMII.This an observational study 70 shock patients. noninvasive bedside haemodynamic monitoring were done using...
OBJECTIVE: To analyze the correlation between glycocalyx disruption measured via serum syndecan-1 level and organ dysfunctions assessed by PELOD-2 score to evaluate its association with mortality in pediatric sepsis. METHODS: We performed a prospective observational study tertiary public hospital. Sixty-eight patients diagnosed sepsis according International Pediatric Sepsis Consensus Conference criteria were consecutively recruited. measurements of day 1 5 levels components. Patients...