A5103210893- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Retinoids in leukemia and cellular processes
- Glaucoma and retinal disorders
- Cancer Genomics and Diagnostics
- Fatty Acid Research and Health
- Cerebral Venous Sinus Thrombosis
- Acute Myeloid Leukemia Research
- Migraine and Headache Studies
- Cerebrovascular and genetic disorders
- Antioxidant Activity and Oxidative Stress
- Genetics, Aging, and Longevity in Model Organisms
- Immunotherapy and Immune Responses
- Lipid metabolism and disorders
- Galectins and Cancer Biology
- Vitamin D Research Studies
- Infections and bacterial resistance
- Mycobacterium research and diagnosis
- Advanced biosensing and bioanalysis techniques
- Atherosclerosis and Cardiovascular Diseases
- Blood Coagulation and Thrombosis Mechanisms
- Infectious Diseases and Tuberculosis
- Ocular Oncology and Treatments
- interferon and immune responses
- Retinal Development and Disorders
Harvard University
2001-2012
Massachusetts Eye and Ear Infirmary
2001-2012
Harvard University Press
2007-2010
Nuffield Orthopaedic Centre
2006
The purpose of this study was to obtain information regarding the effects exercise on longevity in rats. used voluntary activity wheel running. runners gradually decreased their running from approximately 4 1 mile/day as they aged 9 30 mo. lived slightly but significantly longer than sedentary freely eating controls and pair-fed (1,012 +/- 138 vs. 923 160 928 186 days) less long food-restricted paired-weight (1,113 150 days). Although improved survival, it did not result an extension...
<h3>Objective</h3> To examine if the genes encoding complement factor H (<i>CFH</i>), apolipoprotein E (<i>APOE</i>), and elongation of very-long-chain fatty acids–like 4 (<i>ELOVL4</i>) confer risk neovascular age-related macular degeneration (AMD) in an independent or interactive manner when controlling for smoking exposure. <h3>Methods</h3> We studied 103 unrelated patients with AMD who each had at least 1 sibling normal maculae. Smoking histories were obtained. Genotyping was performed...
Vitamin D has been shown to have anti-angiogenic properties and play a protective role in several types of cancer, including breast, prostate cutaneous melanoma. Similarly, vitamin levels be for risk number conditions, cardiovascular disease chronic kidney disease, as well numerous autoimmune disorders such multiple sclerosis, inflammatory bowel diseases type 1 diabetes mellitus. A study performed by Parekh et al. was the first suggest age-related macular degeneration (AMD) showed...
Abstract Background To examine if the significantly associated SNPs derived from genome wide allelic association study on AREDS cohort at NEI (dbGAP) specifically confer risk for neovascular age-related macular degeneration (AMD). We ascertained 134 unrelated patients with AMD who had one sibling an classification 1 or less and was past age which affected diagnosed (268 subjects). Genotyping performed by both direct sequencing Sequenom iPLEX system technology. Single SNP analyses were...
We assessed for mutations in a large number of oncogenes and tumor suppressor genes primary uveal melanomas using high-throughput profiling system.DNA was extracted purified from 134 tissue samples fresh-frozen tissues (n = 87) or formalin-fixed, paraffin-embedded 47) 124 that underwent treatment by enucleation. DNA subjected to whole genome amplification MALDI-TOF mass spectrometry-based mutation (>1000 tested across 120 genes) the OncoMap3 platform. All candidate mutations, as well...
Objectives:The retinoic acid receptor (RAR)-related orphan ␣ gene (RORA) is implicated as a candidate for age-related macular degeneration (AMD) through previous microarray expression study, linkage data, biological plausibility, and 2 clinic-based crosssectional studies.We aimed to determine if common variants in RORA predict future risk of neovascular AMD. Methods:We measured genotypes 18 intron 1 the among 164 cases who developed AMD 485 age-and sex-matched controls prospective, nested,...
β‐Carotene is a naturally occurring carotenoid reported to have health‐promoting effects in several species. Advancing age known negative impact on various immune variables This study was conducted order assess the effect of response dogs and determine whether β‐carotene able reverse this age‐associated decline. To test hypothesis, young old (n = 36) were fed either control diet or experimental diets containing supplemental for 2‐month periods. Age significantly (P < .05) lowered CD4+ T...
A 68-year-old woman with a medical history significant for psoriatic arthritis was found to have an enlarged, painful lump on her left hip 15 months after intramedullary rod placement subtrochanteric femur fracture sustained in fall. Histopathological findings showed rice body formation (RBF) concurrent H. parainfluenza. RBF is relatively rare arthropathy of subset chronic inflammatory disease such as rheumatoid or tuberculous arthropathy. associated orthopedic hardware has been reported...
Abstract Comprehensive genetic evaluation of patients with blood cancer can be imperative for identifying and classifying myeloid malignancies in a patient. Since liquid tumors comprise highly variable percentages normal cells or multiple tumor clones, this type screening is critical early stage disease where cytogenetic profile informs diagnosis stratification, prognosis, treatment options. For late-stage disease, testing assist choosing options alternative treatments, including targeted...