Abstract Brain diseases including neurological disorders and tumors remain under treated due to the challenge access brain, blood-brain barrier (BBB) restricting drug delivery which, also profoundly limits development of pharmacological treatment. Focused ultrasound (FUS) with microbubbles is sole method open BBB noninvasively, locally, transiently facilitate delivery, while translation clinic challenging long procedure, targeting limitations, or invasiveness current systems. In order...

Current methods of cardiac strain imaging at high frame rate suffer from motion matching artifacts or poor lateral resolution. Coherent compounding has been shown to improve echocardiographic image quality while maintaining a rate, but never used strain. However, myocardial velocity can have an impact on coherent due displacements between frames. The objective this paper was investigate the feasibility and performance for low velocity. Left-ventricular contraction in short-axis view modeled...

Harmonic motion imaging for focused ultrasound (HMIFU) utilizes an amplitude-modulated HIFU beam to induce a localized focal oscillatory simultaneously estimated. The objective of this study is develop and show the feasibility novel fast beamforming algorithm image reconstruction using GPU-based sparse-matrix operation with real-time feedback. In study, was implemented onto fully integrated, clinically relevant HMIFU system. A single divergent transmit used while delay-and-sum method...

Abstract A significant risk of femoral neck (FN) fracture exists for men and women with an areal bone mineral density (aBMD) higher than the osteoporotic range, as measured dual-energy X-ray absorptiometry (DXA). Separately measuring cortical trabecular FN compartments combining results would likely be a critical aspect enhancing diagnostic capabilities new technique. Because shell determines large part strength novel quantitative ultrasound (QUS) technique that probes compartment was...

Intracardiac echocardiography (ICE) is a useful imaging modality which used during RF ablation procedures to identify anatomical structures. Utilizing ICE in conjunction with myocardial elastography (ME) can provide additional information on the mechanical properties of cardiac tissue and changes caused by ablation. The objective this study was demonstrate that be at high frame rate using diverging beam transmit sequence image strain differentiate before, during, after for clinical...

Passive acoustic mapping enables the spatiotemporal monitoring of cavitation with circulating microbubbles during focused ultrasound (FUS)-mediated blood-brain barrier opening. However, computational load for processing large data sets maps or more complex algorithms limit visualization in real-time treatment and adjustment. In this study, we implemented a graphical unit (GPU)-accelerated sparse matrix-based beamforming time exposure acoustics neuronavigation-guided system cavitation. The...

Characterization and mapping of arrhythmias is currently performed through invasive insertion manipulation cardiac catheters. Electromechanical wave imaging (EWI) a non-invasive ultrasound-based technique, which tracks the electromechanical activation that immediately follows electrical activation. Electrical activations were previously found to be linearly correlated in left ventricle, but relationship has not yet been investigated three other chambers heart. The objective this study was...

Noninvasive measurement of mechanical properties biological tissues in vivo could play a significant role improving the current understanding tissue biomechanics. In this study, we propose method for measuring elastic non-invasively by using internal indentation as generated harmonic motion imaging (HMI). HMI, an oscillating acoustic radiation force is produced focused ultrasound transducer at focal region, and resulting displacements are estimated tracking radiofrequency signals acquired...

Coherent compounding methods using the full or partial transmit aperture have been investigated as a possible means of increasing strain measurement accuracy in cardiac imaging; however, optimal parameters either approach yet to be determined. The relationship between estimation and parameters-specifically subaperture, angular aperture, tilt angle, number virtual sources, frame rate-in (subaperture compounding) (steered fundamental mode imaging was thus compared. Field II simulation 3-D...

A high volume rate and performance ultrasound imaging method based on a matrix array is proposed by using compressed sensing (CS) to reconstruct the complete dataset of synthetic transmit aperture (STA) from three-dimensional (3D) diverging wave transmissions (i.e. 3D CS-STA). Hereto, series apodized waves are transmitted fixed virtual source, with ith row Hadamard taken as apodization coefficients in event. Then CS used dataset, linear relationship between backscattered echoes STA. Finally,...

WSS measurement is challenging since it requires sensitive flow measurements at a distance close to the wall. The aim of this study develop an ultrasound imaging technique which combines vector with unsupervised data clustering approach that automatically detects region wall optimally linear profile, provide direct and robust estimation. proposed was evaluated in phantoms, mimicking normal atherosclerotic vessels, spatially registered Fluid Structure Interaction (FSI) simulations. A relative...

Harmonic Motion Imaging for Focused Ultrasound (HMIFU) is a technique that can perform and monitor high-intensity focused ultrasound (HIFU) ablation. An oscillatory motion generated at the focus of 93-element 4.5 MHz center frequency HIFU transducer by applying 25 Hz amplitude-modulated signal using function generator. A 64-element 2.5 imaging with 68kPa peak pressure confocally placed to acquire radio-frequency (RF) channel data. In this protocol, real-time monitoring thermal ablation an...

Atrial arrhythmias affect millions of people worldwide. Characterization and study in the atria clinic is currently performed point by using mapping catheters capable generating maps electrical activation rate or cycle length. In this paper, we describe a new ultrasound-based technique called electromechanical length (ECLM) estimating rate, length, i.e., mechanical myocardium which follows activation. ECLM relies on frequency analysis incremental strain within can be single acquisition. was...

Radio frequency (RF) ablation of the myocardium is used to treat various cardiac arrhythmias. The size, spacing, and transmurality lesions have been shown affect success procedure; however, there currently no method directly image size formation in real time. Intracardiac myocardial elastography (ME) has previously decrease strain during systole ablated region as a result lesion formation. However, feasibility imaging multiple identifying presence gaps between not yet investigated. In this...

Catheter ablation is a common treatment for arrhythmia, but can fail if lesion lines are noncontiguous. Identification of gaps and nontransmural lesions reduce the likelihood failure recurrent arrhythmia. Intracardiac myocardial elastography (IME) strain imaging technique that provides visualization line. Estimation size gap resolution were evaluated in an open-chest canine model ( n = 3 ), clinical feasibility was investigated patients undergoing to treat typical cavotricuspid isthmus (CTI)...

Unfocused ultrasound imaging, particularly coherent compounding with diverging waves, is a commonly employed high-frame rate transmit strategy in cardiac strain imaging. However, the accuracy and precision of wave imaging compared to focused-beam approaches human subjects unknown. Three strategies—coherent composite focused ECG gating narrow-beams, wide-beams—were simulation transthoracic healthy (n = 7). The narrow-beam sequence estimated radial end-systolic cumulative strains simulated...

Methods used in clinical practice to diagnose and monitor atherosclerosis present limitations. It has been reported that alters the mechanical properties of arterial wall, while stiffness a plaque can provide information on its risk for rupture stroke occurrence. Pulse Wave Imaging (PWI) is non-invasive, ultrasound-based technique, which provides wall by imaging pulse wave propagation along an segment. Wall shear stress also considered as one key cardiovascular parameters associated with...