A5066136090- Neuroscience and Music Perception
- Animal Vocal Communication and Behavior
- Music and Audio Processing
- Genetics and Neurodevelopmental Disorders
- Neurobiology of Language and Bilingualism
- Cancer-related molecular mechanisms research
- Health, Environment, Cognitive Aging
- Machine Learning in Bioinformatics
- Cardiovascular Health and Risk Factors
- Children's Physical and Motor Development
- Topic Modeling
- Language and cultural evolution
- Music Therapy and Health
- Functional Brain Connectivity Studies
- Fractal and DNA sequence analysis
Vanderbilt University Medical Center
2023-2024
Phenotypic investigations have shown that actively engaging with music, i.e., playing a musical instrument or singing may be protective of motor decline in aging. For example, music training associated enhanced sensorimotor skills accompanied by changes brain structure and function. Although it is possible the benefits active engagement "transfer" to domain, also genetic architecture behaviour system influence engagement. This study investigated whether polygenic scores (PGS) for five...
Language is a unique trait of the human species, which genetic architecture remains largely unknown. Through language disorders studies, many candidate genes were identified. However, such complex and multifactorial unlikely to be driven by only few case-control suffering from lack power, struggle uncover significant variants. In parallel, neuroimaging has significantly contributed understanding structural functional aspects in brain recent availability large scale cohorts like UK Biobank...
Impaired musical rhythm abilities and developmental speech-language related disorders are biologically clinically intertwined. Prior work examining their relationship has primarily used small samples; here, we studied associations at population-scale by conducting the largest systematic epidemiological investigation to date (total N = 39,092). Based on existing theoretical frameworks, predicted that impairment would be a significant risk factor for in general adult population. Findings were...
Rhythm and language-related traits are phenotypically correlated, but their genetic overlap is largely unknown. Here, we leveraged two large-scale genome-wide association studies performed to shed light on the shared genetics of rhythm (N=606,825) dyslexia (N=1,138,870). Our results reveal an intricate neurobiological architecture, lay groundwork for resolving longstanding debates about potential co-evolution human language musical traits.
Abstract This study aimed to test theoretical predictions over biological underpinnings of previously documented phenotypic correlations between human language-related and musical rhythm traits. Here, after identifying significant genetic rhythm, dyslexia various traits, we adapted multivariate methods capture signals common genome-wide association studies ( N = 606,825) 1,138,870). The results revealed 16 pleiotropic loci P < 5 × 10 −8 ) jointly associated with impairment dyslexia,...
Abstract Language is a unique trait of the human species, which genetic architecture remains largely unknown. Through language disorders studies, many candidate genes were identified. However, such complex and multifactorial unlikely to be driven by only few case-control suffering from lack power, struggle uncover significant variants. In parallel, neuroimaging has significantly contributed understanding structural functional aspects in brain recent availability large scale cohorts like UK...