A5032258130- Photoacoustic and Ultrasonic Imaging
- Optical Coherence Tomography Applications
- Antimicrobial agents and applications
- Ultrasound and Hyperthermia Applications
- Traumatic Brain Injury and Neurovascular Disturbances
- Phenothiazines and Benzothiazines Synthesis and Activities
- Angiogenesis and VEGF in Cancer
- Synthesis and Biological Evaluation
- Retinal Imaging and Analysis
- Advanced Fluorescence Microscopy Techniques
- Glaucoma and retinal disorders
- Biochemical effects in animals
- Neurological Disorders and Treatments
Far Eastern State Medical University
2015-2022
Seneca Polytechnic
2018-2021
Analysis of semi-transparent low scattering biological structures in optical coherence tomography (OCT) has been actively pursued the context lymphatic imaging, with most approaches relying on relative absence signal as a means detection. Here we present an alternate methodology based spatial speckle statistics, utilizing similarity distribution given voxel intensities to power function pure noise, visualize low-scattering interest. In human tumor xenograft murine model, show that these...
Texture analyses of optical coherence tomography (OCT) images have shown initial promise for differentiation normal and tumor tissues. This work develops a fully automatic volumetric delineation technique employing quantitative OCT image speckle analysis based on Gamma distribution fits. We test its performance in-vivo using immunodeficient mice with dorsal skin window chambers subcutaneously grown models. Tumor boundaries detection is confirmed epi-fluorescence microscopy, combined...
Radiation therapy (RT) is widely and effectively used for cancer treatment but can also cause deleterious side effects, such as a late-toxicity complication called radiation-induced fibrosis (RIF). Accurate diagnosis of RIF requires analysis histological sections to assess extracellular matrix infiltration. This invasive, prone sampling limitations, thus rarely used; instead, current practice relies on subjective clinical surrogates, including visual observation, palpation, patient...
We present an optical coherence tomography (OCT) lymphangiography visualization approach based on analysis of speckle statistics. For <i>in-vivo</i> experimentation, normal and tumor tissues are examined in mouse dorsal skin window chamber model. In order to evaluate the statistics, OCT datasets acquired 3 spatial 1 temporal dimensions be divided then into smaller volumes interests. dimension, repeated same-location scanning is performed for simultaneous blood vessel detection through...
We propose an alternative optical coherence tomography (OCT) contrast mechanism based on analysis of speckle temporal synchronization using B-mode OCT structural images.We show that the changes in synchronized intensities with time may be used to distinguish between different tissue types, thus providing a novel and potentially useful for imaging.The developed methodology is tested scattering flow phantoms, vivo cervical cancer tumour grown within mouse dorsal skin window chamber...
The aim of the study was to compare effect glyproline peptides RGRGP (Arg-Gly-Arg-Gly-Pro), RGP (Arg-GlyPro), PRPGP (Pro-Arg-Pro-Gly-Pro) and PGPL (Pro-Gly-Pro-Leu) peptide substances at various concentrations on free radical oxidation intensity brain tissues Wistar males after intraperitoneal administration solutions traumatic injury. Material methods . tissue aged 2–3 months ( n = 126) were used in experiment. RGRGP, RGP, PRPGP, provided by Academician N.F. Myasoyedov. Traumatic injury...