A5054154485- Biochemical Analysis and Sensing Techniques
- COVID-19 Clinical Research Studies
- Biochemical effects in animals
- Neurological Disorders and Treatments
- Free Radicals and Antioxidants
- Traumatic Brain Injury and Neurovascular Disturbances
- Dermatological and COVID-19 studies
- Helicobacter pylori-related gastroenterology studies
- Long-Term Effects of COVID-19
- Phytochemicals and Antioxidant Activities
- Reproductive System and Pregnancy
- Bioactive Compounds and Antitumor Agents
- S100 Proteins and Annexins
- Genomics, phytochemicals, and oxidative stress
- Diet, Metabolism, and Disease
- Pharmacological Effects of Natural Compounds
- Medicinal Plants and Bioactive Compounds
- Hematological disorders and diagnostics
- Amino Acid Enzymes and Metabolism
- Receptor Mechanisms and Signaling
- SARS-CoV-2 and COVID-19 Research
- Reproductive biology and impacts on aquatic species
- Bioactive natural compounds
- Ion Transport and Channel Regulation
- Eosinophilic Esophagitis
Far Eastern State Medical University
2007-2025
Brown University
2024
Ministry of Health of the Russian Federation
2012-2023
Far Eastern Federal University
2023
Khabarovsk Scientific Research Institute of Epidemiology and Microbiology
1994-1996
To date, about 70 drugs based on regulatory peptides have been registered, including proline-containing ones, such as the nootropics Semax and Selank. Further study of properties glyproline peptide sequences is relevant in order to describe their neuroprotective possible development new them. The purpose was compare effects three morphometric characteristics proliferative activity brain cells albino rats. Material methods . Sexually mature Wistar male rats were intraperitoneally injected...
Glyprolines have a wide range of pharmacological effects, including antioxidant effects. This can be used to correct functional and morphological disorders the brain after traumatic injury (TBI) by inhibiting secondary damage, prevention which is main way improve TBI outcomes. The aim study was investigate level apoptosis in cells proper parietal lobe (PPL) CA1 field hippocampus mature male Wistar rats mild course glyproline RPGP (Arg-Pro-Gly-Pro). Material methods . Rat tissues ( n = 38)...
Alpha-ketoglutarate (α-KG) is required for chromatin demethylation but mechanisms controlling α-KG abundance in the nucleus are poorly defined. Therefore, we designed a biosensor system to monitor this metabolite pool human cells using an α-KG-responsive cyanobacterial transcription factor, NtcA. We then coupled with genetic screen identify genes that regulate nucleus, defining inter-organelle pathway which sequential mitochondrial activities of GPT2 transaminase and SLC25A11 transporter...
Endosome maturation requires progressive lumen acidification. To what extent is acidification sensed by cytosolic-side molecules that drive endosome maturation? We show here "inside-out" proton signaling through the endosomal Na+/H+ Exchanger 6 (NHE6) activates late master regulator Rab7. The mechanism involves potent inactivation of Rab7 GTPase-activating protein (GAP) TBC1D5 with decreasing pH. NHE6 interacts in a complex Neurons from NHE6-null mice or engineered selective defect efflux...
Objective : Comparative evaluation of the effect regulatory peptides on lipid peroxidation in brain tissue after traumatic injury (TBI). Methods Reproductive Wistar male rats were divided into 3 groups: first group received 0.1 mg/kg “Selang” peptide solution (Thy-Lys-Pro-Arg-Pro-Gly-Pro) within 5 days experimental injury, second AGAPGP (Arg-Gly-Arg-Pro-Gly-Pro), third (control) – 0.9% sodium chloride solution. Drugs administered retroperitoneally. Results According to chemiluminescence...
Red bone marrow samples investigation in deceased COVID-19 patients enabled to identify the phenomena of secondary hemophagocytosis. Analysis data showed that phagocytic reactions during infection with SARS-CoV-2 are manifested both relation erythrocytes and leukocytes. The obtained make it possible expand strategy therapeutic measures, taking into account new on mechanisms pathogenesis severe viral based morphological findings additional information involvement young lymphocytes structure...
With the emerging of new strains SARS-CoV-2 coronavirus (such as B.1.1.529 for example), despite numerous studies to create effective vaccines, it becomes obvious that relevance studying pathomorphology tissue structures with damaged cellular targets has increased manifold. Most knowledge on genes pathogenicity loses its importance development antiviral agents since reservoir virus is cells, in which then persists. These data are more important and treatment strategy should be based targets....
The aim of the study was to compare effect glyproline peptides RGRGP (Arg-Gly-Arg-Gly-Pro), RGP (Arg-GlyPro), PRPGP (Pro-Arg-Pro-Gly-Pro) and PGPL (Pro-Gly-Pro-Leu) peptide substances at various concentrations on free radical oxidation intensity brain tissues Wistar males after intraperitoneal administration solutions traumatic injury. Material methods . tissue aged 2–3 months ( n = 126) were used in experiment. RGRGP, RGP, PRPGP, provided by Academician N.F. Myasoyedov. Traumatic injury...
Using the method of immune histochemistry, qualitative and quantitative features gender hormone receptors in structure mucous membrane epithelium woman cervix postmenopausal period were studied its relationship with proliferative activity keratinocytes was explored. The significance estrogen deficiency epithelial is shown. Additional targets for therapeutic action have been identified order to regulate normalize prevent neoplasia malignancy cervical epithelium. It has established that most...
Intensity of free radical oxidation processes in vivo (model induced oxidative stress) was studied after the probe introduction Vaccinium axillare Nakai fruit extract. Material and methods. Four groups (n = 40) white male CBA mice weighing 20–25 g were included experiment: 1 – intact control; 2–0.9 % sodium chloride solution administered per os for 10 days a dose ml/kg/day; 3 group “cisplatin” (animals received 0.9 similarly to 2, on fifth day experiment cisplatin once by intraperitoneal...