A5089946620- Neuropeptides and Animal Physiology
- Pharmacological Receptor Mechanisms and Effects
- Heat shock proteins research
- Toxin Mechanisms and Immunotoxins
- Viral Infections and Immunology Research
- Receptor Mechanisms and Signaling
- Heavy Metal Exposure and Toxicity
- Child Nutrition and Water Access
- Phenothiazines and Benzothiazines Synthesis and Activities
- Viral gastroenteritis research and epidemiology
- Endoplasmic Reticulum Stress and Disease
- Viral Infectious Diseases and Gene Expression in Insects
- Neuroscience, Education and Cognitive Function
- Antibiotic Use and Resistance
- Metabolism, Diabetes, and Cancer
- Antibiotic Resistance in Bacteria
- Pancreatic function and diabetes
- Diet and metabolism studies
- Antibiotics Pharmacokinetics and Efficacy
- Food Security and Health in Diverse Populations
- Hepatitis Viruses Studies and Epidemiology
- Bacterial Genetics and Biotechnology
- Sulfur-Based Synthesis Techniques
- Chemical synthesis and alkaloids
- Pediatric health and respiratory diseases
Sam Houston State University
2021-2024
Indiana University Bloomington
2022
University of Iowa
2015
City College of New York
2010-2013
International Centre for Diarrhoeal Disease Research
2005-2007
University of Minnesota
1992-1994
Twin Cities Orthopedics
1992-1994
University of Washington
1992
Abstract Approximately 20,000 stool specimens from patients with diarrhea visiting an urban and a rural hospital in Bangladesh during January 2001–May 2006 were tested for group A rotavirus antigen, 4,712 (24.0%) positive. G P genotyping was performed on subset of 10% the positive samples (n = 471). During 2001–2005 seasons, G1P[8] (36.4%) G9P[8] (27.7%) dominant strains, but G2[4] G12P[6] present 15.4% 3.1% rotavirus-positive patients, respectively. 2005–06 season, G2P[4] (43.2%) appeared...
Quality control systems facilitate polypeptide folding and degradation to maintain protein homeostasis. Molecular chaperones promote folding, whereas the ubiquitin/proteasome system mediates degradation. We show here that Saccharomyces cerevisiae Ubr1 Ubr2 ubiquitin ligases of unfolded or misfolded cytosolic polypeptides. also catalyzes ubiquitinylation denatured but not native luciferase in a purified system. This activity is based on direct interaction with Ubr1, although Hsp70 stimulates...
Abstract Background Rotavirus genotyping is performed by using reverse transcription PCR with type-specific-primers. Because the high rotavirus mutation rate generates an extensive genomic variation, different G-type-specific primer sets are applied in geographical locations. In Bangladesh, a significant proportion (36.9%) of strains isolated 2002 could not be G-typed routinely used set. To investigate reason why were untypeable, nucleotide sequencing VP7 genes was performed. Results Four...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of naltrexone-derived .delta.-opioid antagonists. Role conformation the .delta. address moietyP. S. Portoghese, M. Sultana, T. Moe, and A. E. TakemoriCite this: J. Med. Chem. 1994, 37, 5, 579–585Publication Date (Print):March 1, 1994Publication History Published online1 May 2002Published inissue 1 March 1994https://pubs.acs.org/doi/10.1021/jm00031a006https://doi.org/10.1021/jm00031a006research-articleACS PublicationsRequest reuse...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT.delta. Opioid antagonist activity and binding studies of regioisomeric isothiocyanate derivatives naltrindole: evidence for .delta. receptor subtypesP. S. Portoghese, M. Sultana, W. L. Nelson, P. Klein, A. E. TakemoriCite this: J. Med. Chem. 1992, 35, 22, 4086–4091Publication Date (Print):October 1, 1992Publication History Published online1 May 2002Published inissue 1 October...
The UBR1 ubiquitin ligase promotes degradation of proteins via the N-end rule and by another mechanism that detects a misfolded conformation. Although was shown recently to act on protein kinases whose misfolding promoted inhibition Hsp90, it unknown whether this targeted other client types chaperone. We analyzed role in nuclear receptors are classical clients Hsp90. Our results showed deletion impaired glucocorticoid receptor androgen but not estrogen α. These findings demonstrate...
Diarrheal diseases and respiratory infections (RI) are two leading causes of childhood mortality in low middle-income countries. Effective handwashing at critical time-points may mitigate these diseases. However, there is a lack published data investigating this association school-aged children India. This study part larger prospective intervention low-income community New Delhi, India examining the associations between behavior diarrhea RI schoolchildren. current reports findings baseline...
Nutritional metals (NM) are essential for neurodevelopment and cognitive performance during growth. Nevertheless, epidemiological evidence regarding the associations between NM brain function remains understudied, particularly among adolescents. Therefore, objective of this pilot study was to examine effects biomarkers such as iron (Fe), selenium (Se), zinc (Zn), magnesium (Mg), copper (Cu) on neurobehavioral functions a group rural Bangladeshi