A5023618206- Cancer Diagnosis and Treatment
- Electrochemical sensors and biosensors
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and biological activity
- Bone Tumor Diagnosis and Treatments
- Advanced Nanomaterials in Catalysis
- Palliative Care and End-of-Life Issues
- Graphene and Nanomaterials Applications
- Oral and Maxillofacial Pathology
- Quinazolinone synthesis and applications
- Ferroptosis and cancer prognosis
- Geriatric Care and Nursing Homes
- Carbon and Quantum Dots Applications
- Patient-Provider Communication in Healthcare
- Intracerebral and Subarachnoid Hemorrhage Research
- Anatomy and Medical Technology
- Epigenetics and DNA Methylation
- Spine and Intervertebral Disc Pathology
- Family and Patient Care in Intensive Care Units
- Dental Implant Techniques and Outcomes
- Childhood Cancer Survivors' Quality of Life
- Neuroinflammation and Neurodegeneration Mechanisms
- Nanoparticles: synthesis and applications
- Optical Imaging and Spectroscopy Techniques
- Neurological Disorders and Treatments
Rice University
2018-2023
Brigham and Women's Hospital
2023
Harvard University
2023
Harvard University Press
2023
Instituto Tecnológico Superior de Xalapa
2021
Jackson Memorial Hospital
2019-2020
Luzerner Kantonsspital
2019-2020
University of Mendoza
2018-2019
Baylor College of Medicine
2018-2019
University of Minnesota Children's Hospital
2018
WHAT THIS ARTICLE TELLS US THAT IS NEW: BACKGROUND:: Complications in pediatric regional anesthesia are rare, so a large sample size is necessary to quantify risk. The Pediatric Regional Anesthesia Network contains data on more than 100,000 blocks administered at 20 children's hospitals. This study analyzed the risk of major complications associated with children.This prospective, observational routine clinical practice. Data were collected every block placed by an anesthesiologist...
Graphene quantum dots (GQDs) have recently been employed in various fields including medicine as antioxidants, primarily because of favorable biocompatibility comparison to common inorganic dots, although the structural features that lead biological activities GQDs are poorly understood. Here, we report coal-derived and their poly(ethylene glycol)-functionalized derivatives serve efficient evaluate electrochemical, chemical, vitro activities.
Therapy for intracerebral hemorrhage (ICH) remains elusive, in part dependent on the severity of itself as well multiple deleterious effects blood and its breakdown products such hemin free iron. While oxidative injury genomic damage have been seen following ICH, details this implications remain unclear. Here, we discovered that, while iron produced mostly reactive oxygen species (ROS)-related single-strand DNA breaks, unexpectedly induced rapid persistent nuclear mitochondrial double-strand...
The superoxide dismutase-like activity of poly(ethylene glycolated) hydrophilic carbon clusters (PEG-HCCs), anthracite and bituminous graphene quantum dots (PEG-aGQDs PEG-bGQDs, respectively), two fullerene nanozymes, tris malonyl-C60 (C3) polyhydroxylated-C60 (C60-OHn), were compared using direct optical stopped-flow kinetic measurements, together with three native dismutases (SODs), CuZnSOD, MnSOD, FeSOD, at both pH 12.7 8.5. Computer modeling including SOD catalytic steps self-dismutation...
Introduction: While oxidative stress can be measured during transient cerebral ischemia, antioxidant therapies for ischemic stroke have been clinically unsuccessful. Many antioxidants are limited in their range and/or capacity quenching radicals and generate toxic intermediates overwhelming depleted endogenous protection. We developed a new class, 40 × 2 nm carbon nanoparticles, hydrophilic clusters, conjugated to poly(ethylene glycol) termed PEG-HCCs. These particles high superoxide...
Carbon-based superoxide dismutase (SOD) mimetic nanozymes have recently been employed as promising antioxidant nanotherapeutics due to their distinct properties. The structural features responsible for the efficacy of these nanomaterials antioxidants are, however, poorly understood. Here, process-structure-property-performance properties coconut-derived oxidized activated charcoal (cOAC) nano-SOD mimetics are studied by analyzing how modifications nanomaterial's synthesis impact size, well...
PEGylated hydrophilic carbon clusters are electron transfer catalysts between NADH and cytochrome C.
We evaluated the What Matters to Me Workbook, a patient-facing version of Serious Illness Conversation Guide co-created by Ariadne Labs and The Project. purposively recruited diverse seriously ill patients caregivers in US. Participants completed survey, semi-structured in-depth interview about their experience. Qualitative analysis interviews notes was employed extract themes. Simple descriptive statistics were analyze eight investigator authored questions. Twenty-nine study participants...
Background: The worldwide impact of the coronavirus disease 2019 (COVID-19) pandemic on healthcare system is evident. Primary facilities in Philippines face challenges due to lack unified local frameworks that outline strategies and implementation methods for sustaining maternal child health (MCH) services amid ongoing pandemic. This study aimed identify facilitators barriers accessing prenatal care among pregnant women primary during COVID-19
Hypotension worsens outcome after all severities of traumatic brain injury (TBI), with loss cerebral autoregulation being a potential contributor. Previously, we demonstrated that intravenous injection high capacity catalytic antioxidant, poly(ethylene)glycol conjugated hydrophilic carbon clusters (PEG-HCCs) rapidly restored perfusion and acutely oxidative balance in TBI model complicated by hemorrhagic hypotension without evidence toxicity. Here, tested whether these acute effects...
The synthesis of a variety novel 5-substituted titled compounds containing priviledged rhodanine scaffold is described.The involves microwave (MW) assisted Knoevenagel condensation 3-(2-methyl-5,6,7,8-tetrahydrobenzo[4,5]thieno [2,3-d]pyrimidin-4-yl)-2-thioxothiazolidin-4one with suitably substituted aromatic aldehydes.However, these condensations fail aliphatic aldehydes.The 2-thioxothiazolidin-4-one (rhodanine) precursor was prepared by the...
Abstract Knoevenagel condensation of thiazole (I) with various (het)aryl aldehydes gives the title compounds in high yields either under microwave irradiation or conventional heating.
Patient and family advisory councils (PFACs) represent one method of engaging patients families in clinical program development research, but existing practices too often exclude marginalized minority voices. As a kidney palliative care team (KidneyPal) at large academic medical center, we sought to create PFAC that explicitly considered equity inclusion its approach advisor recruitment. We developed two major innovations reduce selection bias our KidneyPal PFAC: adaptation an entirely...
We studied the acceptability, ease-of-use, usefulness, and safety of What Matters to Me Workbook, a patient-facing version Serious Illness Conversation Guide co-created by Ariadne Labs The Project.We recruited seriously ill patients caregivers in USA. Participants completed survey, semi-structured in-depth interview about their experience. Qualitative analysis interviews notes was employed extract themes. Simple descriptive statistics were analyze eight investigator authored questions...
Abstract The biologically important title structures (III) can be prepared in an easy manner with good to excellent yields.
Introduction: An attractive treatment target following intracerebral hemorrhage (ICH) are reactive oxidative stress (ROS) reactions occurring after contact with blood breakdown products, such as hemin and iron. Recent work suggests the ferroptosis cell death pathway predominates ICH, likely secondary to ROS free iron consuming key protection pathways. While studies directed at deferoxamine (DEF) underway, DEF suffers from poor cellular uptake, short shelf life toxicity. We report a new...