A5081840466- Synthesis of β-Lactam Compounds
- Infant Development and Preterm Care
- Estrogen and related hormone effects
- Animal Virus Infections Studies
- Enzyme function and inhibition
- Synthesis and Catalytic Reactions
- Phenothiazines and Benzothiazines Synthesis and Activities
- Antibiotics Pharmacokinetics and Efficacy
- Sleep and related disorders
- Streptococcal Infections and Treatments
- Wastewater Treatment and Nitrogen Removal
- Chemical Synthesis and Reactions
- Stress Responses and Cortisol
- Metal complexes synthesis and properties
- Microbial Community Ecology and Physiology
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Antibiotic Resistance in Bacteria
- Chemical Synthesis and Analysis
- Electrolyte and hormonal disorders
- Sleep and Wakefulness Research
- Hepatitis C virus research
- Kawasaki Disease and Coronary Complications
- Childhood Cancer Survivors' Quality of Life
- Chemical Reaction Mechanisms
- Seedling growth and survival studies
Hokkaido University Hospital
2021-2024
Tokyo Women's Medical University Yachiyo Medical Center
2021-2022
Tokyo Women's Medical University
1989-2022
Kansai Medical University
2017-2019
WellStar Health System
2018
Tohoku University
2014-2015
Okayama Prefecture
2014-2015
Tenshi Hospital
2014
Sapporo Hokuyu Hospital
2014
Obihiro Kosei General Hospital
2014
WHAT THIS ARTICLE TELLS US THAT IS NEW: BACKGROUND:: Complications in pediatric regional anesthesia are rare, so a large sample size is necessary to quantify risk. The Pediatric Regional Anesthesia Network contains data on more than 100,000 blocks administered at 20 children's hospitals. This study analyzed the risk of major complications associated with children.This prospective, observational routine clinical practice. Data were collected every block placed by an anesthesiologist...
Docetaxel is one of the most effective anticancer drugs available in treatment breast cancer. Nearly half treated patients, however, do not respond to chemotherapy and suffer from side effects. The ability reliably predict a patient's response based on tumor gene expression will improve therapeutic decision making save patients unnecessary effects.A total 44 tissues were sampled by biopsy before with docetaxel, therapy was clinically evaluated degree reduction size. Gene profiling samples...
SUMMARY The core protein of hepatitis C virus (HCV) is considered to be cleaved from the N terminus large precursor polyprotein by cellular signalase. HCV cDNA encoding was expressed (i) in monkey COS cells a plasmid expression vector driven SRα promoter, and (ii) insect recombinant baculovirus. product had an M r 22000 located cytoplasm. When C-terminal hydrophobic domains were deleted, however, truncated proteins translocated into nucleus. nucleus even when they as fusion with E. coli...
Estradiol (E2) and estrone (E1) levels as well mRNA expression of aromatase, sulfatase 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) in breast cancer tissues were studied to elucidate the mechanism involved maintenance intratumoral high E2 postmenopausal patients with very low serum levels. Intratumoral (127.2 ± 17.5 pg/g) (mean SE) not significantly different from those premenopausal (110.1 10.1 (p = 0.36). The aromatase sulfatase, determined by a quantitative real-time PCR, between...
Abstract We studied the relationship between response of breast cancer to docetaxel (DOC) or cylophosphamide + epirubucin (CE) treatment and CYP3A4 mRNA expression in tumors. inactivates DOC but not E, which is a predominant effector CE treatment. Twenty patients with locally advanced tumors 18 recurrent underwent tumor biopsy before chemotherapy, levels tissues were assayed by real‐time quantitative polymerase chain reaction. Twenty‐three treated (60 mg/m 2 q3w) 15 (C 600 E 60 q3w)....
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAngiotensin-converting enzyme inhibitors. Perhydro-1,4-thiazepin-5-one derivativesHiroaki Yanagisawa, Sadao Ishihara, Akiko Ando, Takuro Kanazaki, Shuichi Miyamoto, Hiroyuki Koike, Yasuteru Iijima, Kiyoshi Oizumi, Yoichi Matsushita, and Tadashi HataCite this: J. Med. Chem. 1987, 30, 11, 1984–1991Publication Date (Print):November 1, 1987Publication History Published online1 May 2002Published inissue 1 November...
The expression levels of the Wilms' tumor gene WT1 were examined in 34 primary thyroid cancers (24 papillary, 5 follicular, 1 anaplastic, and 4 medullary carcinomas), 17 follicular adenomas, 6 normal‐appearing tissues using quantitative real‐time reverse transcriptase‐polymerase chain reaction (RT‐PCR). In 33 cancers, mRNA was expressed at ranging from 5.0×10 −5 to 8.3×10 −2 ( level K562 leukemic cells defined as 1.0). significantly higher than those either adenomas (P<0.001) or...
alpha-[(3S)-3-[[(S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-2-oxo-6 or 7-phenylperhydroazepin-1-yl]acetic acids (monoester monoacids) and their dicarboxylic were synthesized, angiotensin-converting enzyme (ACE) inhibitory activities evaluated. The having phenyl substituents at the 6R, 6S, 7S positions on azepinone ring showed potent inhibition in vitro. corresponding monoester monoacids, when administered orally, suppressed pressor response to angiotensin I intravenously. monoacids...
Musty-odorous compounds, metabolites of some species blue-green algae, are usually contained in both the water and algal cell bodies. The compounds latter solid phase were found to be easily removed by coagulation sedimentation without breakpoint prechlorination (intermediate chlorination used instead). Chlorination algae results an artificial release metabolite content into surrounding water. When a large fraction was present bodies, more than 60% these intermediate-chlorination treatment....
Abstract An 18 year old girl with typical clinical features of Williams syndrome suddenly died intracerebral hemorrhage due to moyamoya disease. Autopsy revealed vascular abnormalities, such as supravalvular aortic stenosis (SAS) and an abnormal complicated cerebrovascular network in the cerebral arteries. The arterial wall SAS lesion consisted thickened medial tissue showing elastic disorganization prominence smooth muscle cells. narrowed vessels circle Willis showed intimal thickening...
A Chinese hamster ovary cell line was established which abundantly expresses the second envelope protein (E2) of hepatitis C virus under control an exogenous promoter. The expressed E2 found to be a glycoprotein 58 kDa by immunoprecipitation with sera from patients that had chronic C. Using this as antigen in immunofluorescence tests, high 93% non-A non-B antibodies against protein. In Western blots using SDS-denatured protein, however, detectability antibody drastically reduced 30%....
Sulfonamide or phosphonic acid analogs of oxolinic (I) and nalidixic (II), in which the carboxyl groups I II were replaced by sulfamoyl phosphono groups, synthesized conveniently modification Camps'es quinoline synthesis. They evaluated for antimicrobial activity but no significant was noted.
Abstract Background Children born with very low birth weight (VLBW) are at higher risk for cognitive impairment, including language deficits and sensorimotor difficulties. Voice-evoked response (P1m), which has been suggested as a development biomarker in young children, remains unexplored its efficacy VLBW children. Furthermore, the relation between P1m sensory difficulties children unclear. Methods 40 were recruited 5-to-6 years old (26 male, 14 female, mean age of months ± SD, 80.0 4.9)....