A5100437387- MicroRNA in disease regulation
- Sperm and Testicular Function
- Circadian rhythm and melatonin
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Reproductive Physiology in Livestock
- Reproductive Biology and Fertility
- Estrogen and related hormone effects
- Hormonal and reproductive studies
- Sleep and Wakefulness Research
- Cancer Mechanisms and Therapy
- Aluminum Alloy Microstructure Properties
- Hedgehog Signaling Pathway Studies
- Reproductive System and Pregnancy
- PI3K/AKT/mTOR signaling in cancer
- Immune Cell Function and Interaction
- RNA modifications and cancer
- Curcumin's Biomedical Applications
- Autophagy in Disease and Therapy
- NF-κB Signaling Pathways
- Microstructure and mechanical properties
- T-cell and B-cell Immunology
- Effects and risks of endocrine disrupting chemicals
- Hematopoietic Stem Cell Transplantation
Tongji University
2025
Tongji Hospital
2025
Harbin University of Science and Technology
2024
Xinjiang University
2023-2024
Northeast Normal University
2024
Northwest A&F University
2019-2023
Ministry of Agriculture and Rural Affairs
2021-2023
Jilin Agricultural University
2022
Ministry of Agriculture, Livestock, and Food Supply
2019-2020
University of Science and Technology of China
2019
Preserving hematopoietic stem cell (HSC) functionality is essential for maintaining healthy blood and the immune system throughout life. HSC function declines with age; however, underlying mechanisms are not fully understood. Using an inducible mosaic mouse model to overexpress transcription factor Bcl11a in compartment, we found that aging-related increase mitigated functional decline, promoted IL-1β production bone marrow (BM), accelerated attrition a non–cell-autonomous manner....
Osteosarcoma is an aggressive cancer of the skeletal system which remains a challenge for current therapeutic strategies due to unclear etiology and molecular mechanisms pathogenesis. The study aimed determine expression levels, role mechanism microRNA-708-5p (miR-708-5p) in development osteosarcoma. level miR-708-5p was detected using reverse transcription-quantitative polymerase chain reaction. overexpressed SaOS-2 cells mimics. Cell viability, apoptosis, migration invasion were determined...
Abstract Immature Sertoli cell (SC) proliferation determines the final number of mature SCs and further regulates spermatogenesis. Accumulating evidence demonstrated that microRNAs (miRNAs) play an important role in SC proliferation, differentiation, apoptosis. However, effect molecular mechanism miRNA on bovine immature remain to be poorly understood. In this study, sequencing testes collected (24-mo old) (neonatal) bulls was conducted determine expression profiles. MicroRNA-34b one...
To elucidate the complex physiological process of testis development and spermatogenesis in Sika deer, this study evaluated changes miRNA mRNA profiles four developmental stages juvenile (1-year-old), adolescence (3-year-old), adult (5-year-old), aged (10-year-old) stages. The results showed that a total 198 mature, 66 novel miRNAs, 23,558 differentially expressed (DE) unigenes were obtained; 14,918 (8,413 up 6,505 down), 4,988 (2,453 2,535 5,681 (2,929 2,752 down) DE unigenes, as well 88...
Prostaglandin G/H synthase 2 (PTGS2) is a rate-limiting enzyme in prostaglandin synthesis. The present study assessed the role of uterine circadian clock on Ptgs2 transcription response to steroid hormones during early pregnancy. We demonstrated that core genes (Bmal1, Per2, Nr1d1, and Dbp), Vegf, Ptgs2, their encoded proteins, have rhythmic expression mouse uterus from days 3.5 4.5 (D3.5-4.5) Progesterone (P4) treatment cultured endometrial stromal cells (UESCs) isolated mPer2Luciferase...
Abstract In ruminant, adequate endometrial function is a major factor affecting implantation and economic efficiency. However, the precise mechanisms regulating goat during peri‐implantation period of pregnancy are still unclear. Here, we investigated functional role signal transduction fifth component constitutive photomorphogenic‐9 signalosome (COPS5) in regulation epithelial cells (EECs). Our results showed that hormones decreased COPS5 expression, COPS5‐mediated function. We also found...
Previous study has found that PRSS50 (TSP50) is highly expressed in spermatocytes, and our aims to investigate its role testicular development spermatogenesis. We first knockdown hindered DNA synthesis of spermatocytes. Then we generated Prss50-/- (PRSS50 knockout) mice it exhibited abnormal compression spermatid nucleus reduced male fertility. Furthermore, dysplasia seminiferous tubules along with lower levels sex hormones were observed 4-week-old accompanied by defects meiotic progression...
MiRNAs play an important role in the occurrence and development of human disease. Identifying potential miRNA-disease associations is valuable for disease diagnosis treatment. Therefore, it urgent to develop efficient computational methods predicting reduce cost time associated with biological wet experiments. In addition, high-quality feature representation remains a challenge association prediction using graph neural network methods. this paper, we propose method named ESGC-MDA, which...
Hypopharyngeal carcinoma is notorious for its poor prognosis among all head and neck cancers, posing a persistent challenge in clinical settings. The continuous hyperactivation of the NFκB signalling pathway has been noted various cancer types, including hypopharyngeal carcinoma. In our quest to develop novel drug that targets via pathway, we employed curcumin, well-known lead compound, performed chemical modifications create mono-carbonyl analogue called L42H17. This compound exhibited...
Due to the lack of high-quality Sika Deer ( Cervus nippon ) transcriptome and sRNAome across multiple organs or development stages, it is impossible comprehensively analyze mRNA miRNA regulatory networks related growth, immunity response. In this study, we used single molecule-real time sequencing (SMRT-seq) Illumina methods generate from ten tissues four age groups help us understand molecular characteristics global expression profiles. The results showed that a total 240,846 consensus...