Lei Zhang

ORCID: 0000-0002-5832-7175
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About
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Research Areas
  • Pancreatic and Hepatic Oncology Research
  • Pancreatitis Pathology and Treatment
  • Salivary Gland Tumors Diagnosis and Treatment
  • Corneal Surgery and Treatments
  • Gallbladder and Bile Duct Disorders
  • Ocular Surface and Contact Lens
  • Cholangiocarcinoma and Gallbladder Cancer Studies
  • Organ Transplantation Techniques and Outcomes
  • Oral and Maxillofacial Pathology
  • Sarcoma Diagnosis and Treatment
  • COVID-19 Clinical Research Studies
  • Immune Cell Function and Interaction
  • Salivary Gland Disorders and Functions
  • Gastrointestinal Tumor Research and Treatment
  • Metastasis and carcinoma case studies
  • Vitamin C and Antioxidants Research
  • Diagnosis and treatment of tuberculosis
  • Head and Neck Anomalies
  • Lung Cancer Treatments and Mutations
  • Vitamin D Research Studies
  • thermodynamics and calorimetric analyses
  • Enhanced Recovery After Surgery
  • Ferroptosis and cancer prognosis
  • Oral Health Pathology and Treatment
  • Cerebral Venous Sinus Thrombosis

Nanjing University
2021-2024

Songjiang District Central Hospital
2024

Shanghai First People's Hospital
2024

Nanjing Medical University
2024

China-Japan Friendship Hospital
2020-2021

Affiliated Hospital of Nantong University
2021

Nantong University
2021

First Affiliated Hospital of Zhengzhou University
2021

Harbin Medical University
2015-2020

Second Affiliated Hospital of Harbin Medical University
2020

Adenoid cystic carcinoma (ACC) is a relatively rare slow-growing and often-aggressive epithelial-myoepithelial neoplasm that arises in multiple organs including the skin. The t(6;9) (q22-23;p23-24) translocation, resulting MYB-NFIB gene fusion has been found ACCs from salivary glands other organs. Recently, MYB aberrations occurring subset (40%) of primary cutaneous ACC (PCACC) examples was described. Herein, we report three additional cases PCACC harboring aberrations. tumors presented...

10.1111/cup.12856 article EN Journal of Cutaneous Pathology 2016-11-08

Mild acute pancreatitis (MAP) is a common abdominal disease, and exhibits rising incidence in recent decades. As an important component of systemic biology, metabonomics new discipline developed following genomics proteomics. In this study, the objective was to analyze serum patients with MAP, aiming screen metabolic markers potential diagnostic values.An analysis platform ultra performance liquid chromatography-high-resolution mass spectrometry used difference metabolites related MAP...

10.1002/jcla.21969 article EN Journal of Clinical Laboratory Analysis 2016-05-12

<i>Objective:</i> To observe the effects of cyclic adenosine monophosphate (cAMP) in peripheral lymphocytes on T helper 1 (TH1)/TH2 cytokine ratios and to investigate potential impact mechanism β-adrenergic receptor antagonists immune function patients with chronic heart failure (CHF). <i>Methods:</i> Sixty-nine New York Heart Association functional class II–IV CHF a radionuclide left ventricular ejection fraction less than 45% received carvedilol or metoprolol...

10.1159/000319375 article EN NeuroImmunoModulation 2010-10-13

Thoracic endovascular aortic repair (TEVAR) is widely used for type B dissection, although with satisfactory outcome in a limited proportion of patients. To better inform patient prognostication, the Registry Of dissection Utility STent graft (ROBUST) study aims to identify imaging-based predictors post-TEVAR adverse outcomes up 10-year follow-up.ROBUST designed as an ambispective, multicentre, open cohort study. All patients undergoing TEVAR from 1 January 2008 July 2027 at participating...

10.1136/bmjopen-2017-019317 article EN cc-by-nc BMJ Open 2017-12-01

Submandibular gland autotransplantation is effective for treating severe dry eye syndrome. However, more than 40% of patients show epiphora within 3-6 months after treatment. The mechanism underlying the hypersecretion in remains to be elucidated developing novel interventions. Since salivary secretion dependent on a variety proteins, we analyzed changes protein expression transplanted glands with 2-D gel electrophoresis and electrospray ionization quadrupole/time-of-flight mass spectrometry...

10.1021/pr100965q article EN Journal of Proteome Research 2011-03-09

Objectives This study was intended to establish normal values for velocities in the hepatic artery and portal veins pediatric patients after total pancreatectomy islet autotransplantation (TPIAT). Methods A retrospective review performed of liver Doppler studies TPIAT over 6 years at an academic children's hospital. vasculature resistive index were recorded. Results Sixty‐five evaluated. There no cases vein thrombosis or other vascular complications. The mean peak systolic velocity 157.6...

10.1002/jum.14617 article EN Journal of Ultrasound in Medicine 2018-04-15

Acute pancreatitis (AP) has been reported in patients treated with protease inhibitors (PIs), but there are few real-world studies comparing the occurrence and characteristics of AP after different PI regimens.Disproportionality analysis Bayesian were utilized for data mining Food Drug Administration's Adverse Event Reporting System (FAERS) database suspected adverse events involving PI. The times to onset fatality rates following regimens also compared.Based on 33,832 reports related PIs,...

10.1080/14740338.2021.1933942 article EN Expert Opinion on Drug Safety 2021-05-21

To investigate whether capsaicin and carbachol promote secretion from prevent duct obstruction in transplanted submandibular glands (SMGs).This retrospective cohort study included consecutive patients with severe keratoconjunctivitis sicca successful SMG transplantation. Patients were divided into 2 groups: an exposed group receiving both after surgery unexposed neither. Secretion changes response to administration recorded the group. The main outcome measures secretory flow rate...

10.1097/ico.0000000000000752 article EN Cornea 2016-01-24

Leukemoid reaction (LR) is defined as a reactive leucocytosis with WBC counts exceeding 50,000/mm3, and significant increase in early neutrophil precursors. LR may be paraneoplastic manifestation of various malignant tumors. Tumor-related kind neoplastic syndrome, unrelated to an infection or other diseases. A 74-year-old male visited local doctor 20-day history progressive dysphagia. The complete blood count revealed leucocytosis. Bone marrow aspirates biopsy confirmed excluded chronic...

10.1186/s13019-019-0893-z article EN cc-by Journal of Cardiothoracic Surgery 2019-04-08

To explore and analyze the feasibility of using indocyanine green (ICG) near-infrared fluorescence (NIF) imaging technology for early diagnosis oral potential malignant disorders squamous cell carcinoma.

10.7518/hxkq.2024.2024150 article EN PubMed 2024-12-01

To investigate the correlation between sonographic and computed tomography pathological features of basal cell adenomas (BCAs) parotid gland. This retrospective study included 41 patients (43 tumors) with BCAs. The tumors were divided into three types based on their location in gland imaging features. analyzed. Imaging manifestations corresponding results most BCAs glands resembled those benign tumors. Malignant transformation occurred membranous extensive cribriform structures. Type-II...

10.1155/2021/7906058 article EN cc-by Computational and Mathematical Methods in Medicine 2021-12-06

Abstract Background Breast cancer has the highest incidence rate and causes most fatalities among all female cancers worldwide. Triple-negative breast (TNBC) is known for its strong invasiveness higher rates of recurrence. In this research, we aimed to identify MIR4435-2HG as a promising long non-coding RNA (lncRNA) biomarker therapeutic target TNBC. Methods Utilizing clinicopathological information transcriptome data from The Cancer Genome Atlas (TCGA) database, assessed clinical relevance...

10.21203/rs.3.rs-3832143/v1 preprint EN cc-by Research Square (Research Square) 2024-01-16

Comparisons between brand and biosimilar basal insulin in hospitalized patients are lacking. We aimed to compare the efficacy safety of glargine vs. non-critical with type 2 diabetes mellitus (T2DM). This retrospective study was conducted using electronic medical records 194,006 at Qingdao Endocrine Diabetes Hospital January 2006 December 2017. A total 476 diagnosed T2DM, hospitalized, treated subcutaneous were included. After propensity score matching (1:3), who received (Basalin) (n = 34)...

10.1007/s12325-019-00922-9 article EN cc-by-nc Advances in Therapy 2019-03-21

Abstract Backgrounds: The potential therapeutic effects of protease inhibitors (PIs), such as lopinavir/ritonavir and darunavir, on COVID-19 are being tested in clinical trials. Although acute pancreatitis (AP) has been reported patients treated with PIs, there have few real-world studies comparing the occurrence characteristics AP after different PI regimens. Methods: Disproportionality analysis Bayesian were utilized for data mining Food Drug Administration's Adverse Event Reporting System...

10.21203/rs.3.rs-31947/v1 preprint EN cc-by Research Square (Research Square) 2020-06-09
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