Background Alcohol dependence is a complex psychiatric disorder demanding development of novel pharmacotherapies. Because the cyclic adenosine monophosphate ( cAMP ) signaling cascade has been implicated in mediating behavioral responses to alcohol, key components this may serve as potential treatment targets. Phosphodiesterase‐4 PDE 4), an enzyme that specifically catalyzes hydrolysis , represents point regulating intracellular levels. Thus, it was interest determine whether 4 involved...

New protein synthesis has been implicated as necessary for long-lasting changes in neuronal function. Behavioural sensitization to a single exposure addictive drugs is form of neuroplasticity, but little known about the importance new underlying mechanism. This study was designed investigate effects transcription inhibitor actinomycin D (AD) and cycloheximide (CHX) on induction behavioural morphine mice. In combination with experiments, gene expression mouse nucleus accumbens (NAc) were...

De-novo protein synthesis is required in the development of behavioural sensitization. A prior screening test from our laboratory has implicated heat shock 70 (Hsp70) as one proteins this plasticity. Thus, study was designed to extend understanding role Hsp70 sensitization induced by a single morphine exposure mice. First, employing transcription inhibitor actinomycin D (AD) and cycloheximide (CHX), we identified synthesis-dependent labile phase (within 4 h after first injection) exposure....

Drug addiction is a major public health issue, yet the underlying adaptation of neural networks by drugs abuse not fully understood. We have previously linked chaperone heat shock protein 70 (Hsp70) to drug-induced adaptations. Focusing on NAc core and shell, present study aims provide further findings for our understanding relation between behavioural sensitization morphine Hsp70 at transcriptional functional levels in rats. Firstly, we delineated characteristics induced single exposure...

Abstract Ginsenoside Re, an active ingredient in Panax ginseng , is widely used as a therapeutic and nutriment. The intestinal microbiota plays crucial roles modulating the pharmacokinetics pharmacological actions of ginsenoside Re. aim this study was to explore relationship between bacterial community variety metabolic profiles We developed two models with dysbacteriosis: pseudo‐germ‐free model induced by nonabsorbable antimicrobial mixture (ATM), Qi‐deficiency established via over‐fatigue...

Intrathecal morphine infusion therapy via a percutaneous port (IMITPP) has been used widely for its relatively low initial cost. However, there is scarce knowledge about IMITPP. In this study, we sought to evaluate efficacy, complications, and the interval required achieve cost equivalence of IMITPP in patients with refractory cancer pain China.A retrospective chart review was conducted on who had received at our hospital between April 2017 2019. Data from numeric rating scale Karnofsky...

Abstract: Intrathecal morphine provides superior analgesia and minimizes side effects with ~1/300th of the oral dose necessary to achieve this effect. The conversion ratios from route intrathecal vary greatly among individuals, may be related polymorphisms ATP-binding cassette B1 ( ABCB1 )/ multiple drug resistance 1 MDR1 ) gene encoding transporter P-glycoprotein in blood–brain barrier. In case presented herein, a patient cancer pain for over 3 months was treated oxycodone hydrochloride...

Acute pancreatitis (AP) has been reported in patients treated with protease inhibitors (PIs), but there are few real-world studies comparing the occurrence and characteristics of AP after different PI regimens.Disproportionality analysis Bayesian were utilized for data mining Food Drug Administration's Adverse Event Reporting System (FAERS) database suspected adverse events involving PI. The times to onset fatality rates following regimens also compared.Based on 33,832 reports related PIs,...

Digoxin is a frequently prescribed drug, particularly in the elderly population, which there an increased prevalence of atrial fibrillation and cardiac failure. With its complex pharmacokinetic profile narrow therapeutic index, use digoxin requires regular monitoring blood levels. Recent evidence suggests that lower concentration range (0.4-1.0 ng/mL) preferable patients with congestive heart failure higher (0.8-2.0 needed tachyarrhythmia. The Konishi equation widely used to predict serum...

Abstract Introduction Intrathecal therapy (ITT) via an implanted system was demonstrated for the treatment of refractory cancer pain decades. Recently, dissemination ITT is enhanced in external way Asia a lower implantation cost. This study compares efficacy, safety, and cost two systems patients China. Methods One hundred thirty‐nine who underwent were included. three received (external group), while 36 (implanted group). A 1:2 propensity score matching procedure used to yield total 89...

What is known and objective Teicoplanin widely used for the treatment of infections caused by drug-resistant Gram-positive bacteria. Since there a good correlation between trough levels clinical outcome, therapeutic drug monitoring (TDM) recommended to achieve better curative effects. However, TDM teicoplanin not routine in China. So, programme was initiated 2017, including both HPLC method establishment interlaboratory quality assessment, measurement teicoplanin. Methods A main centre...

The clinical use of opioid analgesics, such as morphine, is limited by analgesic tolerance, molecular mechanism which not well understood. Recently, chaperone heat shock protein 70 (Hsp70) has been demonstrated to play important roles in morphine-induced neuroadaptation. Here, we focused on the involvement Hsp70 development tolerance morphine. Rats were treated with morphine (5, 10, 20 mg/kg, subcutaneously) or saline once daily for 10 consecutive days. modulator N -formyl-3,...

The association between polymorphisms of the human ATP binding cassette subfamily B member 1 (ABCB1) gene and opioid response has attracted intense attention recently. As ABCB1 encodes for transporter P-glycoprotein in brain intestine involved pharmacokinetics opioids, we investigated effects genetic on doses opioids pain relief determined which pharmacokinetic process was affected cancer patients. Sixty-eight patients admitted intrathecal therapy (ITT) were included. (C3435T, C1236T,...

In Section 2.2. 'Animal Experiments' of their article, the authors noted that: "All animal studies were conducted in accordance with protocols approved by Animal Ethics Committee China Japan Friendship Hospital" (Zhang et al., 2018). Following concerns raised to journal a reader regarding study's ethical approval process, would like inform readers that, due translation error and misunderstanding prospective for this study was mistakenly not sought. However, followed relation care use animals...

Limited knowledge and poor attitudes toward pain are major barriers to nursing management of cancer pain. This study investigated the effect continuing education (CNE) on pain.Annual CNE was provided from 2016 2019, evaluation conducted every 2 years. The determined based results.After annual CNE, participating hospitals showed significant improvement in Annual significantly increased subscores all domains except domain initial assessment. In terms hospital levels, improved only for tertiary...

Abstract Backgrounds: The potential therapeutic effects of protease inhibitors (PIs), such as lopinavir/ritonavir and darunavir, on COVID-19 are being tested in clinical trials. Although acute pancreatitis (AP) has been reported patients treated with PIs, there have few real-world studies comparing the occurrence characteristics AP after different PI regimens. Methods: Disproportionality analysis Bayesian were utilized for data mining Food Drug Administration's Adverse Event Reporting System...

Purpose: To establish a pharmacist-led olaparib follow-up program for ovarian cancer patients, provide patient education, get information on adverse drug reactions (ADRs), and identify manage drug-related problems. Methods: Ambulatory adult patients with receiving were enrolled. At least one session was conducted by clinical pharmacists. Pharmacists collected data the type grade of ADRs, adherence, dosing, concomitant medications, pharmacists' suggestions. Results: 83 enrolled median age 58....

Pharmacists are key members of the pain management interdisciplinary team in many developed countries. However, implementation clinical pharmacy services is impeded by imbalance between physicians and pharmacists specializing China. The purpose this study was to elucidate perceptions, expectations current experience Chinese regarding services.An anonymous, self-administered questionnaire designed according previously published studies with minor modifications distributed online 1100 selected...

Objective: To observe the effect of low dose naloxone combinewith ropivacaine for supraclavicular brachial plexus block. Methods: Seventy patients undergoing elective upper limb surgery were randomly divided into two groups, group (Group R, n=35) and N, n=35). An ultrasound guided technique was used in both groups.The onset duration time sensory motor blockade, visual analog score(VAS)of 3, 6, 12, 18, 24 h postoperatively, first request fordezocine, total amount dezocine needed, incidence...

Objective To explore the clinical significance and gene mutation profiles of renal transplant patients with unconjugated hyperbilirubinemia (Gilbert’s syndrome). Methods Genomic DNA was extracted from peripheral blood samples 8 Gilbert’S syndrome. UGT1A1 * 6 28 genotypes were identified through digital fluorescence molecular hybridization sequencing. Results There are 2 cases UGT1A1*28 heterozygous mutant, 3 UGT1A1*6 homozygous case 1 mutant combined...