A5007622225- Click Chemistry and Applications
- Synthesis and biological activity
- Synthesis and Biological Evaluation
- Clinical Nutrition and Gastroenterology
- Diet and metabolism studies
- Histone Deacetylase Inhibitors Research
- Crystallization and Solubility Studies
- Gut microbiota and health
- X-ray Diffraction in Crystallography
- Cholinesterase and Neurodegenerative Diseases
- Bioactive Compounds and Antitumor Agents
Instituto Politécnico Nacional
2021-2023
Myeloperoxidase (MPO) is an enzyme present in human neutrophils, whose main role to provide defenses against invading pathogens. However, highly reactive oxygen species (ROS), such as HOCl, are generated from MPO activity, leading chronic diseases. Herein, we report the microwave-assisted synthesis of a new series stable (E)-(2-hydroxy)-α-aminocinnamic acids, good yields, which structurally analogous natural products (Z)-2-hydroxycinnamic acids. The radical scavenging activity (RSA),...
Although the aetiology of inflammatory bowel diseases (IBDs) is still unknown, one their main characteristics that immune system chronically affects permeability intestinal lamina propria, in turn altering composition microbiota. In this study, TNBS rat model colitis was used because it contains a complex milieu polymorphonuclear cells (PMN) and lymphocytes infiltrating propria. The aim present study to investigate six dehydrogenases respective adaptations tissue microenvironment by...
Breast cancer (BC) is the most frequently diagnosed and second-most common cause of death in women worldwide. Because this, search for new drugs targeted therapy to treat BC an urgent global need. Histone deacetylase 6 (HDAC6) a promising anti-BC drug target associated with its development progression. In present work, design synthesis family dihydropyrazole-carbohydrazide derivatives (DPCH) focused on HDAC6 inhibitory activity presented. Computational chemistry approaches were employed...
Breast cancer (BC) is the most frequently diagnosed and second cause of death in women worldwide. Then, search for new drugs targeted therapy to treat BC an urgent global need. Histone deacetylase 6 (HDAC6) a promising anti-BC drug target associated with its development progression. In present work, design synthesis family dihydropyrazole-carbohydazide derivatives (DPCH) focused on HDAC6 inhibitory activity presented. Computational chemistry approaches were employed rationalize evaluate...