A5067147695- Phytochemicals and Antioxidant Activities
- Exercise and Physiological Responses
- Antioxidant Activity and Oxidative Stress
- Computational Drug Discovery Methods
- Estrogen and related hormone effects
- Vitamin C and Antioxidants Research
- Breast Cancer Treatment Studies
- Histone Deacetylase Inhibitors Research
- Adipose Tissue and Metabolism
- Health and Lifestyle Studies
- Obesity, Physical Activity, Diet
- Cancer Risks and Factors
- Nitric Oxide and Endothelin Effects
- Pregnancy and preeclampsia studies
- Biosimilars and Bioanalytical Methods
- Ion channel regulation and function
- Monoclonal and Polyclonal Antibodies Research
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- HER2/EGFR in Cancer Research
- Phytoestrogen effects and research
- Cardiac electrophysiology and arrhythmias
- Neuroscience and Neural Engineering
- Cardiovascular and exercise physiology
- Effects and risks of endocrine disrupting chemicals
Instituto Politécnico Nacional
2015-2024
Joslin Diabetes Center
2019
Tecnológico Nacional de México
2016-2017
Instituto de Investigación Sanitaria del Hospital Clínico San Carlos
2014-2015
Hospital Clínico San Carlos
2015
Instituto de Salud Carlos III
2015
East Carolina University
2006
The University of Texas MD Anderson Cancer Center
2006
Complejo Hospitalario de Salamanca
2006
The University of Texas Health Science Center at Houston
2005
Natural compounds such as (-)-epicatechin show a variety of biological properties including anticancer activity. Nonetheless, (-)-epicatechin's therapeutic application is limited due to its low water solubility and sensitivity oxygen light. Additionally, previous studies have reported that the encapsulation flavonoids in nanoparticles might generate stable deliverable forms, which improves availability bioactive compounds. The aims this study were (-)-epicatechin-loaded lecithin-chitosan...
(-)-Epicatechin is a phenolic compound with antioxidant activity that present in natural food and drinks, such as cocoa red wine. Evidence suggests (-)-epicatechin exhibits anticancer activity; however, its mechanism of action poorly understood. Here, we investigated the effects breast cancer cells. We assessed by cell proliferation assays, apoptosis DNA fragmentation flow cytometry. The expression proteins associated was analyzed human array. MitoSOX
AbstractThe epidermal growth factor receptor (EGFR) is important for normal development, differentiation, and cell proliferation. Deregulation of EGFR has been observed in breast cancer. signal pathways activated by these receptors have associated with an advanced tumor stage a poor clinical prognosis cancer, however, the precise mechanisms responsible this process are still not known. Here we show that treatment MCF-7 cancer cells EGF Akt ERK, induced morphological changes, increased...
Epigenetic alterations are associated with cancer and their targeting is a promising approach for treatment of this disease. Among current epigenetic drugs, histone deacetylase (HDAC) inhibitors induce changes in gene expression that can lead to cell death tumors. Valproic acid (VPA) HDAC inhibitor has antitumor activity at mM range. However, it known VPA hepatotoxic drug. Therefore, the aim study was design set derivatives adding arylamine core suberoylanilide hydroxamic (SAHA) different...
Introduction and objective:The aim of this communication is to describe the cardiovascular risk factors affecting a Mexican urban middle-class population.Methods: A convenience sample 2602 middle class subjects composed cohort Lindavista Study, prospective study aimed determine if conventional risks have same prognosis impact as in other populations.For baseline data, several measurements were done: obesity indexes, smoking, blood pressure, fasting serum glucose, total cholesterol, HDL-c,...
For this study, procyanidins generated through the autoxidation of (-)-epicatechin (Flavan-3-ol) under mildly acidic conditions (pH = 6.0) were characterized with ultra high-performance liquid chromatography (UHPLC) coupled tandem mass spectrometry (MS/MS). Two (types A and B) a mix oligomers (-)-epicatechin. The antiproliferative activity mixture on MDA-MB-231, MDA-MB-436, MCF-7 breast cancer cells was evaluated. results indicate that procyanidin inhibited proliferation cells, where...
AbstractThe Epidermal Growth Factor (EGF) Receptor (EGFR) plays an important role in the growth and progression of breast cancer. Overexpression EGFR or high activity signal pathway has been related with increases cell proliferation a poor prognosis patients Several human cancer lines depend on estrogen for their proliferation. EGF may bypass requirement cells. To evaluate this hypothesis, MCF-7 cells were stimulated effects proliferation, pathways, cycle determined. The results demonstrate...
Recent reports have demonstrated the role of G Protein-Coupled Estrogen Receptor 1 (GPER1) on proliferation breast cancer. The coupling GPER1 to estrogen triggers cellular signaling pathways related cell proliferation.Develop new therapeutic strategies against cancer.We performed in silico studies explore binding mechanism a set G15 /G1 analogue compounds. We included carboxyl group instead acetyl from G1 form amides with several moieties increase affinity GPER1. designed ligands were...
Obesity and the metabolic syndrome affect a considerable segment of population worldwide, including health professionals. In fact, several studies have reported that physicians tend to more cardiovascular risk factors than their patients. The present cross-sectional study assessed whether Health Sciences students had healthier lifestyle, thus could preventive attitude towards chronic diseases general population.Students medical-biological areas were surveyed by answering questionnaire about...
<i>Background:</i> Studies show that diet and exercise are important in the treatment of obesity. The aim this study was to determine whether additional regular moderate aerobic during a with hypocaloric has beneficial effect on oxidative stress molecular damage obese patient. <i>Methods:</i> Oxidative 16 normal-weight (NW) 32 1 (O1) subjects (BMI 30–34.9 kg/m<sup>2</sup>) were established by biomarkers plasma. Recombinant human insulin incubated blood...
Several studies have demonstrated the protective effects of cocoa consumption, due to its anti-inflammatory and antioxidant properties. Acute exercise induces oxidative stress causes muscular damage during training. This study was designed examine effect consumption on markers muscle damage, physical fitness in professional soccer players.Fifteen players (15-18 years old) were included study. Biochemical parameters, stress, performance evaluated before after consumption. parameters...
The prevalence of diabetes is rapidly increasing. current number diagnosed cases ~422 million, expected to reach ~640 million by 2040. Type 2 diabetes, which constitutes ~95% the cases, characterized insulin resistance and a progressive loss β-cell function. Despite intense research efforts, no treatments are yet able cure disease or halt its progression. Since all existing animal models type have serious drawbacks, one needed that represents complete pathogenesis, low cost non-obese, can be...
Background: Breast cancer is an important cause of cancerrelated death in women. In this pathological condition, arginase plays a role by providing ornithine as substrate for the biosynthesis polyamines which are tumor progression. The aim work was to determine activity plasma and tumors patients with breast cancer; also, we investigated relationship between presence estrogen receptor. Patients Methods: We evaluated levels 80 women 42 healthy control subjects. also measured biopsies tissues....
Background: Some reports have demonstrated the role of G Protein-coupled Estrogen Receptor (GPER) in growth and proliferation breast cancer cells. Objective: In an effort to develop new therapeutic strategies against cancer, we employed silico study explore binding modes tetrahydroquinoline 2 4 be compared with reported ligands G1 G1PABA. Methods: This aimed design filter by studies determining their Lipinski's rule, toxicity properties GPER achieve experimental assays as anti-proliferative...
Communicating clearly about who is included in a population group critical element to effective dissemination and knowledge transfer. This narrative review highlights the inconsistency as it relates communicating individuals with intellectual disability (ID) developmental (DD).
The beta(1a) subunit, one of the auxiliary subunits Ca(V)1.1 channels, was expressed in COS-1 cells, purified by electroelution and electrodialysis techniques identified Western blot using monoclonal antibodies. subunit strongly interacted vitro with alpha interaction domain (AID) channels. actions on channel currents were assessed whole cell voltage clamp experiments performed vesicles derived from frog mouse adult skeletal muscle plasma membranes. L-type inward recorded solutions...
Obesity and its associated disorders constitute a growing epidemic across the world. Numerous studies have demonstrated presence of systemic oxidative stress in patients with obesity. In this study, we show effects present blood from obese on recombinant human insulin. Insulin was incubated whole (WB) overweight subjects (OW), 1 (O1), or normal weight volunteers (NW) (n=16 for each group). Whole OW O1, unlike WB NW, increased carbonyl content insulin; however, only O1 amount formazan...
Cocoa consumption is associated with health benefits due to its high content of polyphenols. However, the effects short-term cocoa remain unclear. We aimed determine generated by (for 7 days) in young adults normoweight and class II obesity.