A5007911342- Amoebic Infections and Treatments
- Parasitic Infections and Diagnostics
- Alzheimer's disease research and treatments
- Pediatric Hepatobiliary Diseases and Treatments
- Advanced Proteomics Techniques and Applications
- RNA modifications and cancer
- Machine Learning in Bioinformatics
- Antifungal resistance and susceptibility
- Quantum Dots Synthesis And Properties
- Plant tissue culture and regeneration
- COVID-19 Clinical Research Studies
- Diagnosis and treatment of tuberculosis
- Cholinesterase and Neurodegenerative Diseases
- Drug Transport and Resistance Mechanisms
- Polysaccharides and Plant Cell Walls
- Microbial Fuel Cells and Bioremediation
- Metabolomics and Mass Spectrometry Studies
- Genomics and Chromatin Dynamics
- S100 Proteins and Annexins
- Essential Oils and Antimicrobial Activity
- Fungal Infections and Studies
- Plant Stress Responses and Tolerance
- Selenium in Biological Systems
- Gold and Silver Nanoparticles Synthesis and Applications
- Genetic Neurodegenerative Diseases
Instituto Politécnico Nacional
2014-2024
Center for Research and Advanced Studies of the National Polytechnic Institute
2012-2024
Pir Mehr Ali Shah Arid Agriculture University
2023
Centro de Investigación en Materiales Avanzados
2010-2019
Tecnológico Nacional de México
2017
Mexican Social Security Institute
2012
Max Planck Institute for Molecular Biomedicine
1999
Universidad de Extremadura
1991
Universidad de Guanajuato
1991
We previously demonstrated that, in the early stages of tau processing Alzheimer's disease, N-terminal part molecule undergoes a characteristic cascade phosphorylation and progressive misfolding proteins resulting structural conformation detected by Alz-50. In this immunohistochemical study AD brain tissue, we have found that C-terminal truncation at Asp-421 was an event aggregation analyzed relationship between phospho-dependent epitopes located C-terminus with Glu-391. The aim to determine...
(-)-Epicatechin is a phenolic compound with antioxidant activity that present in natural food and drinks, such as cocoa red wine. Evidence suggests (-)-epicatechin exhibits anticancer activity; however, its mechanism of action poorly understood. Here, we investigated the effects breast cancer cells. We assessed by cell proliferation assays, apoptosis DNA fragmentation flow cytometry. The expression proteins associated was analyzed human array. MitoSOX
Caralluma tuberculata holds significant importance as a medicinal plant due to its abundance of bioactive metabolites, which offer wide range therapeutic potentials. However, the sustainable production this is challenged by overexploitation, changes in natural conditions, slow growth rate, and inadequate biosynthesis compounds wild populations. Therefore, current study was conducted establish an vitro based elicitation strategy (nano elicitors light regimes) for enhancement biomass secondary...
Background: Since December 2019, the SARS-CoV-2 virus has been highly contagious and pathogenic, causing mild to severe respiratory failure. The most investigated biomarkers can help predict disease progression guide treatment decisions. Expert clinicians suggested that neutrophil-lymphocyte ratio (NLR) platelet-lymphocyte (PLR) represent rapid, easy, widely available, relatively inexpensive tools. Objectives: We aimed explore NLR PLR in predicting poor prognosis of COVID-19 patients Mexican...
The cell surface of Candida albicans is enriched with highly glycosylated mannoproteins that are involved in the interaction host tissues. N- and O-glycosylation post-translational modifications initiate endoplasmic reticulum, finalize Golgi. KRE2/MNT1 family encode a set multifunctional mannosyltransferases participate O-, phosphomannosylation. In order to gain insights into substrate specificities these enzymes, recombinant forms Mnt1, Mnt2, Mnt5 were expressed Pichia pastoris enzyme...
Alzheimer's disease (AD) is the most common cause of dementia in elderly. AD brains are characterized by presence neurofibrillary tangles (NFTs) and neuritic plaques. NFTs constituted paired helical filaments, which structurally composed assembled hyperphosphorylated truncated tau polypeptides. To date, integral constituents remain unknown mainly due to high insolubility NFTs. The aim this study was identify tandem mass spectrometry, polypeptides contained both isolated laser capture...
In vitro plant cultures have emerged as a viable source, holding auspicious reservoirs for medicinal applications. This study aims to delineate the antioxidant and hypoglycemic potential of phytosynthesized selenium nanoparticle (SeNP)- light stress-mediated in callus Caralluma tuberculata extract. The morphophysicochemical characteristics biogenic SeNPs were assessed through combination analytical techniques, including UV–visible spectrophotometry, scanning electron microscopy,...
The commercial-scale production of Caralluma tuberculata faces significant challenges due to lower seed viability and sluggish rate root growth in natural conditions. To overcome these obstacles, using phyto-mediated selenium nanomaterials as an vitro rooting agent plant cultures is a promising approach facilitate rapid propagation enhance the valuable therapeutic compounds. This study aimed investigate impact phytosynthesized nanoparticles (SeNPs) on morphological attributes, physiological...
Alzheimer's disease (AD) is a degenerative and irreversible disorder whose progressiveness dependent on age. It histopathologically characterized by the massive accumulation of insoluble forms tau amyloid-β (Aβ) asneurofibrillary tangles neuritic plaques, respectively. Many studies have documented that these two polypeptides suffer several posttranslational modifications employing postmortem tissue sections from brains patients with AD. In order to elucidate molecular mechanisms underlying...
Abstract Cookies are an exceptional energy source due to their elevated fat and carbohydrate content. Beyond delectable taste, they also rich in essential nutrients, including valuable proteins minerals. This study evaluated the potential of wheat variety NARC‐2011 for cookie production, focusing on nutritional enhancement by adding white sesame seeds at different proportions (5%, 10%, 15%) both whole fine flour. White were added cookies mainly visual appeal, creating a nice contrast with...
The multidrug resistance (MDR) phenotype inEntamoeba histolytica is characterized by the overexpression of EhPgp5 gene in trophozoites grown high drug concentrations. Here we evaluated role ofEhPgp5 mRNA stability on MDR using actinomycin D.EhPgp5 from growing without emetine had a half-life 2.1 h, which augmented to 3.1 h cells cultured with 90 μm and 7.8 225 emetine. Polyadenylation sites were detected at 118-, 156-, 189-nucleotide (nt) positions EhPgp5mRNA 3′-untranslated region....
Background Giardia passes through two stages during its life cycle, the trophozoite and cyst. Cyst formation involves synthesis of cyst wall proteins (CWPs) transport CWPs into encystation-specific vesicles (ESVs). Active vesicular trafficking is essential for encystation, but molecular machinery driving remains unknown. The Rab are involved in targeting to several intracellular compartments their association with cytoskeletal motor proteins. Methodology Principal Findings In this study, we...
Amebiasis is one of the twenty major causes disease in Mexico; however, diagnosis difficult due to limitations conventional microscopy-based techniques. In this study, we analyzed stool samples using polymerase chain reaction-denaturing gradient gel electrophoresis (PCR-DGGE) differentiate between Entamoeba histolytica (pathogenic) and E. dispar (non-pathogenic). The target for PCR amplification was a small region (228 bp) adh112 gene selected increase sensitivity test. study involved 62...