A5024699206- Parasitic Infections and Diagnostics
- Amoebic Infections and Treatments
- Vector-borne infectious diseases
- Toxin Mechanisms and Immunotoxins
- Parasites and Host Interactions
- Vector-Borne Animal Diseases
- Wildlife Ecology and Conservation
- Research on Leishmaniasis Studies
- Viral Infections and Vectors
- Parasitic infections in humans and animals
- Trypanosoma species research and implications
- Parasite Biology and Host Interactions
- Advanced Proteomics Techniques and Applications
- Childhood Cancer Survivors' Quality of Life
- Urological Disorders and Treatments
- Insect and Pesticide Research
- Heat shock proteins research
- Influenza Virus Research Studies
- Urinary Tract Infections Management
- Insect symbiosis and bacterial influences
- Peptidase Inhibition and Analysis
- Mosquito-borne diseases and control
- Malaria Research and Control
- Heme Oxygenase-1 and Carbon Monoxide
- RNA and protein synthesis mechanisms
Instituto Politécnico Nacional
2015-2025
Universidad Nacional Autónoma de México
2023
Iowa State University
2021
Instituto Nacional de Cancerología
2015
Center for Research and Advanced Studies of the National Polytechnic Institute
2002-2007
Royal Holloway University of London
2003-2005
Mitochondrial remnant organelles (mitosomes) that exist in a range of "amitochondrial" eukaryotic organisms represent ideal models for the study mitochondrial evolution and establishment minimal set proteins required biogenesis an endosymbiosis-derived organelle. Giardia intestinalis, often described as earliest branching eukaryote, contains double membrane-bounded structures involved iron-sulfur cluster biosynthesis, essential function mitochondria. Here we present evidence mitosomes also...
<title>Abstract</title> Purpose Soil-transmitted helminth infections affect people who live in areas with poor sanitation, low socioeconomical level. <italic>Ascaris lumbricoides</italic> is one of the most frequent parasites worldwide and México. The General Directorate Epidemiology reports data related to weekly, this study was based on that. aim analyze SINAVE for twenty years (2003–2022) assess incidence ascariasis United Mexican States. Methods We conducted a retrospective observational...
The existence of mitochondrion-related relict organelles (mitosomes) in the amitochondrial human pathogen Entamoeba histolytica and detection extranuclear DNA-containing cytoplasmic structures (EhKOs) has led to suggestion that a remnant genome from original mitochondrial endosymbiont might have been retained this organism. This study reports on mutually exclusive distribution Cpn60 DNA E. Cpn60-containing mitosomes parasite. In situ nick-translation coupled immunofluorescence microscopy...
Babesia bovis belongs to the phylum Apicomplexa and is major causal agent of bovine babesiosis, most important veterinary disease transmitted by arthropods. In apicomplexan parasites, interaction between AMA1 RON2 necessary for invasion process, it a target vaccine development. B. bovis, existence has already been reported; however, presence homolog unknown. The aim this study was characterize in bovis. ron2 gene similar synteny with orthologous bigemina genome. entire sequenced from...
Microfilaments play a determinant role in different cell processes such as: motility, division, phagocytosis and intracellular transport; however, these structures are poorly understood the parasite Giardia lamblia.By confocal microscopy using TRITC-phalloidin, we found structured actin distributed entire trophozoite, label stand out at ventral disc, median body, flagella around nuclei. During encystation, sequence of morphological changes concurrent to modifications on distribution...
Background Giardia passes through two stages during its life cycle, the trophozoite and cyst. Cyst formation involves synthesis of cyst wall proteins (CWPs) transport CWPs into encystation-specific vesicles (ESVs). Active vesicular trafficking is essential for encystation, but molecular machinery driving remains unknown. The Rab are involved in targeting to several intracellular compartments their association with cytoskeletal motor proteins. Methodology Principal Findings In this study, we...
Interferon-induced transmembrane (IFITM) proteins mediate protection against enveloped viruses by blocking membrane fusion at endosomes. IFITM1 and IFITM3 are crucial for influenza, various single nucleotide polymorphisms altering their function have been linked to disease susceptibility. However, bulk mRNA expression dynamics correlation with clinical outcomes not extensively addressed in patients respiratory infections. In this study, we evaluated the of peripheral leukocytes from healthy...
In pathogen recognition, the nucleotide-binding domain (NBD) and leucine rich repeat receptors (NLRs) have noteworthy functions in activation of innate immune response. These respond to several viral infections, among them NOD2, a very dynamic NLR, whose role dengue virus (DENV) infection remains unclear. This research aimed determine human NOD2 THP-1 macrophage-like cells during DENV-2 infection. levels infected was evaluated by RT-PCR Western blot, an increase observed at both mRNA protein...
Babesiosis is a growing concern due to the increased prevalence of this infectious disease caused by Babesia protozoan parasites, affecting various animals and humans. With rising worries over medication side effects emerging drug resistance, there notable shift towards researching babesiacidal agents. Antimicrobial peptides, specifically cathelicidins known for their broad-spectrum activity immunomodulatory functions, have emerged as potential candidates. Aquiluscidin, cathelicidin from...
T-cell acute lymphoblastic leukemia (T-ALL) is a challenging childhood cancer to treat, with limited therapeutic options and high relapse rates. This study explores deamidated triosephosphate isomerase (dTPI) as novel target. We hypothesized that selectively inhibiting dTPI could reduce T-ALL cell viability without affecting normal T lymphocytes. Computational modeling recombinant enzyme assays revealed disulfiram (DS) curcumin (CU) bind inhibit activity the non-deamidated enzyme. At...
Human papillomaviruses (HPVs), the leading cause of cervical cancer, are distributed worldwide, with high prevalence in developing countries.The objective study is to know and genotypes HPV women from state Michoacán Women's Hospital Morelia, Michoacán.Cervical smear samples (159,288) were subjected detection by hybrid capture 2. A subsample 484 patients was studied Papanicolaou test linear array genotyping, when positive, also examined colposcopy histopathology.The overall for State 7.74%;...
Entamoeba histolytica is the causative agent of amoebiasis, a poverty-related disease that kills an estimated 100 000 people each year. E. does not contain ‘standard mitochondria’, but harbours mitochondrial remnant organelles called mitosomes. These are characterized by presence chaperonin Cpn60, little else known about functions and molecular composition In this study, gene encoding Cpn10 – functional partner Cpn60 was cloned, its structure expression were characterized, as well cellular...