A5065529255- Gut microbiota and health
- Histone Deacetylase Inhibitors Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Amoebic Infections and Treatments
- Epigenetics and DNA Methylation
- Heme Oxygenase-1 and Carbon Monoxide
- Pediatric health and respiratory diseases
- Diet and metabolism studies
- Stress Responses and Cortisol
- Estrogen and related hormone effects
- Nerve Injury and Rehabilitation
- Peripheral Nerve Disorders
- IL-33, ST2, and ILC Pathways
- Immune Cell Function and Interaction
- interferon and immune responses
- COVID-19 Clinical Research Studies
- Adipose Tissue and Metabolism
- Diabetes and associated disorders
- Dietary Effects on Health
- Cytokine Signaling Pathways and Interactions
- SARS-CoV-2 and COVID-19 Research
- Air Quality and Health Impacts
- Cancer, Hypoxia, and Metabolism
- Tuberculosis Research and Epidemiology
- Genomics, phytochemicals, and oxidative stress
Instituto Politécnico Nacional
2016-2025
Tecnológico Nacional de México
2016-2025
Objective: The aim of this study is to assess the motor outcomes patients undergoing surgical neurolysis and conduct a comprehensive review existing literature ascertain efficacy utility technique. Surgical procedure designed liberate an injured nerve from scar tissue or adjacent structure, thereby facilitating regeneration in cases brachial plexus neuropathy (BPN). Methods: This presents case series diagnosed with BPN who underwent neurolysis. primary focus was on clinical assessment...
Heat shock proteins (HSP) genes are a superfamily responsible for encoding highly conserved that important antigen presentation, immune response regulation, and cellular housekeeping processes. These can be increased by stress related to pollution, example, smoke from biomass burning and/or tobacco smoking. Single nucleotide polymorphisms (SNPs) in these could affect the levels of their proteins, as well susceptibility developing lung diseases, such chronic obstructive pulmonary disease...
Smoking and smoke from biomass burning (BB) are the main environmental risk factors for COPD. Clinical differences have been described between COPD related to smoking wood smoke, but no studies shown genetic patients exposed these two factors.To investigate a possible association of tumor necrosis factor (TNF) promoter polymorphisms, we conducted case-control study. A total 1,322 subjects were included in four groups: with diagnosis secondary (COPD-S, n=384), (COPD-BB, n=168), smokers...
Abstract Mitochondria are at the centre of molecular events involved in energy production, cell survival and apoptosis. Mitochondrial membrane potential (Δ ψ m ) is maintained by cellular catabolic reactions electron transport chain which cytochrome c a constituent, whereas proton leak pathway, ATP synthesis turnover consume it. alterations such as drop Δ , swelling release have been observed However, there paucity information concerning mitochondrial function course intracellular...
Background: Genetic association studies have identified single nucleotide polymorphisms (SNPs) related to COPD susceptibility. Aim: identify HHIP genetic variants associated with COPD, pulmonary function, and serum sputum protein levels in Mexican mestizo smokers. Material methods: Association analysis was performed by carrying out a case-control study smokers comprising two groups: tobacco-smoking subjects (COPD-TS, n = 222) without (SWOC, 333). We evaluated three SNPs (rs13147758,...
The few reports that have analyzed the effects of stress on immune cells intestinal mucosa or functions these tended to focus S-IgA levels in saliva, and studies shown contradictory results. principal objective this study was analyze repeated restraint number distribution Peyer’s patches (PPs) as well glucocorticoid catecholamine administration same stress-related parameters. Upon analyzing effect PPs, it found there no modification morphological structure PPs but reduced total lymphocytes...
N-(2′-hydroxyphenyl)-2-propylpentanamide (HO-AAVPA) is a VPA derivative designed to be histone deacetylase (HDAC) inhibitor. HO-AAVPA has better antiproliferative effect than in cancer cell lines. Therefore, this work, the inhibitory of on HDAC1, HDAC6, and HDAC8 was determined by silico vitro enzymatic assay. Furthermore, its cervical line (SiHa) translocation HMGB1 ROS production were evaluated. The results showed that inhibits which could related with from nucleus cytoplasm due HDAC1...
// Arturo Contis-Montes de Oca 1, * , Estefanía Rodarte-Valle 2, Martha Cecilia Rosales-Hernández 2 Edgar Abarca-Rojano 3 Saúl Rojas-Hernández 1 Manuel Jonathan Fragoso-Vázquez 4 Jessica Elena Mendieta-Wejebe Ana María Correa-Basurto Ismael Vázquez-Moctezuma and José 5 Laboratorio Inmunobiología Molecular y Celular, Sección Estudios Posgrado e Investigación, Escuela Superior Medicina, Instituto Politécnico Nacional, Ciudad México, México Biofísica Biocatálisis, Respiración Departamento...
Lung microbiome dysbiosis affects the immune system balance and promotes lung inflammation. We aimed to characterize compare bacteriome composition cytokine profile in women with normal function exposed risk factors for chronic diseases (tobacco smoking biomass-burning smoke exposure). included exposure (BE, n = 11) current smokers (TS, 10). The was performed induced sputum, sequencing 16 rRNA gene. Cytokine levels were measured using enzyme-linked immunosorbent assay multiplex supernatant...
A variety of organic materials (biomass) are burned for cooking and heating purposes in poorly ventilated houses; smoke from biomass combustion is considered an environmental risk factor chronic obstructive pulmonary disease COPD. In this study, we attempted to determine the participation single-nucleotide variants HHIP (hedgehog-interacting protein) gene lung function, serum levels, sputum supernatant levels Mexican women with without COPD who were exposed biomass-burning smoke.In a...
Tobacco smoking results in a multifactorial disease involving environmental and genetic factors; epigenome-wide association studies (EWAS) show changes DNA methylation levels due to cigarette consumption, partially reversible upon tobacco cessation. Therefore, could predict status. This study aimed evaluate the level of cg05575921 (AHRR) cg23771366 (PRSS23) their correlation with lung function variables, nicotine addiction Mexican population. We included 114 non-smokers (NS) 102 current...
Although the aetiology of inflammatory bowel diseases (IBDs) is still unknown, one their main characteristics that immune system chronically affects permeability intestinal lamina propria, in turn altering composition microbiota. In this study, TNBS rat model colitis was used because it contains a complex milieu polymorphonuclear cells (PMN) and lymphocytes infiltrating propria. The aim present study to investigate six dehydrogenases respective adaptations tissue microenvironment by...
Amebiasis is an intestinal infection caused by Entamoeba histolytica. Amebic liver abscess (ALA) the most common extraintestinal complication of amebiasis. In animal models ALA, neutrophils have been shown to be first cells come into contact with histolytica during initial phase ALA. One multiple mechanisms which exhibit amebicidal activity through reactive oxygen species (ROS) and enzyme NADPH oxidase (NOX2), generates transports electrons subsequently reduce molecular superoxide anion....