A5089308476- Smoking Behavior and Cessation
- Nutrition, Genetics, and Disease
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Nicotinic Acetylcholine Receptors Study
- Genetic Associations and Epidemiology
- Rheumatoid Arthritis Research and Therapies
- Peptidase Inhibition and Analysis
- Pharmacogenetics and Drug Metabolism
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Viral Infections and Immunology Research
- Blood Coagulation and Thrombosis Mechanisms
- Biochemical Analysis and Sensing Techniques
- Air Quality and Health Impacts
- Immune Cell Function and Interaction
- Neuroscience of respiration and sleep
- vaccines and immunoinformatics approaches
- Neurotransmitter Receptor Influence on Behavior
- Neurosurgical Procedures and Complications
- Genomics, phytochemicals, and oxidative stress
- Protease and Inhibitor Mechanisms
- Sarcoidosis and Beryllium Toxicity Research
- Takotsubo Cardiomyopathy and Associated Phenomena
- Cardiac Imaging and Diagnostics
- T-cell and B-cell Immunology
Hospital Universitario Virgen Macarena
2024
Instituto Nacional de Enfermedades Respiratorias
2017-2023
Universidad Nacional Autónoma de México
2023
Around 50% of rheumatoid arthritis (RA) patients show some extra-articular manifestation, with the lung a usually affected organ; in addition, presence anti-citrullinated protein antibodies (ACPA) is common feature, which caused by citrullination modifications, catalyzed peptidyl arginine deiminases (PAD) enzymes. We aimed to identify single nucleotide variants (SNV) PADI2 and PADI4 genes (PAD2 PAD4 proteins, respectively) associated susceptibility interstitial disease (ILD) RA PAD2 levels....
Genes encoding the receptors involved in dopaminergic and serotonergic pathways are potential candidates mechanisms of nicotine addiction.To identify genetic variants promoter regions exons DRD4 HTR2A genes associated with tobacco smoking degree addiction Mexican mestizos.The study included 438 non-smokers (NS) 1,157 current smokers, ranked based on their consumption cigarettes per day (cpd): 574 heavy smokers (HS, >20 cpd) 583 light (LS, 1-10 cpd). Genotyping was performed for 4 8 single...
Smoking and smoke from biomass burning (BB) are the main environmental risk factors for COPD. Clinical differences have been described between COPD related to smoking wood smoke, but no studies shown genetic patients exposed these two factors.To investigate a possible association of tumor necrosis factor (TNF) promoter polymorphisms, we conducted case-control study. A total 1,322 subjects were included in four groups: with diagnosis secondary (COPD-S, n=384), (COPD-BB, n=168), smokers...
Genetic variability defends us against pathogen-driven antigens; human leucocyte antigens (HLA) is the immunological system in charge of this work. The Mexican mestizo population arises mainly from mixture three founder populations; Amerindian, Spaniards, and a smaller proportion African population. We describe allele haplotype frequencies HLA class I (-A -B) II (-DRB1 -DQB1), which were analyzed by PCR-SSP urban populations Mexico: Chihuahua-Chihuahua City (n = 88), Mexico City-Tlalpan...
The protease inhibitor S (PiS) and Z (PiZ) variants have been stated as the only genetic cause of chronic obstructive pulmonary disease (COPD) in Caucasians. However, its frequency admixed populations is low. We aimed to identify susceptibility between PiS (rs17580) PiZ (rs28929474) polymorphisms with COPD related tobacco smoking biomass-burning smoke well determine frequencies Mestizo Amerindian from Mexico.One thousand eight hundred seventy-eight subjects were included two comparisons...
This article contains data on the single nucleotide polymorphisms (SNPs) rs1137115, rs1801272 and rs28399433 rs4105144 in CYP2A6 associated to smoking related variables Mexican Mestizo smokers (Pérez-Rubio et al., 2017) [1]. These SNPs were selected due previous associations with other populations. classified according their pattern. A genetic association test was performed.
Cigarette smoking is influenced by nicotine's effects on dopaminergic activity, which appear to be moderated genetic variation, particularly a variable number tandem repeat (VNTR, 48 bp) polymorphism in the third exon of dopamine receptor gene (DRD4). Smokers with VNTR ≥7 repeats (long, L allele) report markedly increased participation some behaviors; hence, our aim was evaluate association allele Mexican Mestizo smokers and without COPD. The DRD4 bp genotyped 492 smokers: 164 COPD patients...
Previous studies have identified variants in genes encoding proteins associated with the degree of addiction, smoking onset, and cessation. We aimed to describe thirty-one single nucleotide polymorphisms (SNPs) seven candidate genomic regions spanning six tobacco-smoking a cross-sectional study from two different interventions for quitting smoking: (1) thirty-eight smokers were recruited via multimedia participate e-Decídete! program (e-Dec) (2) ninety-four attended an institutional...
Protein citrullination is accomplished by a broad enzyme family named Peptidyl Arginine Deiminases (PADs), which makes this post-translational modification in many proteins that perform physiological and pathologic mechanisms the body. Due to these modifications, has become significant topic study of pathological processes. It been related some chronic autoimmune diseases, including rheumatoid arthritis (RA), interstitial lung diseases (ILD), multiple sclerosis (MS), certain types cancer,...
Rheumatoid arthritis (RA) is an autoimmune disease mainly characterized by joint inflammation. It presents extra-articular manifestations, with the lungs being one of affected areas. Among these, damage to pulmonary interstitium (Interstitial Lung Disease—ILD) has been linked proteins involved in inflammatory process and related extracellular matrix deposition lung fibrosis establishment. Peptidyl arginine deiminase enzymes (PAD), which carry out protein citrullination, play a role this...
Rheumatoid arthritis (RA) is an autoimmune disease mainly characterized by joint inflammation. It presents extra-articular manifestations, with the lungs one of affected areas. Among these, damage to pulmonary interstitium (Interstitial Lung Disease -ILD) has been linked proteins involved in inflammatory process and related extracellular matrix deposition lung fibrosis establishment. Peptidyl arginine deiminase enzymes (PAD), which carry out protein citrullination, play a role this context....
<b>Introduction:</b> Tobacco smoking is a complex and multifactorial disease involving both environmental genetic factors. In Mexican mestizo population, single-nucleotide polymorphisms (SNP) associated with cigarette greater degree of nicotine addiction have been identified; however, no possible roles explored the age initiation smoking, nor in success quitting smoking. <b>Methods:</b> present study 151 smokers were included, grouped according to at which they started (table 1), those who...
This article contains data on the allele and genotype frequency for single nucleotide polymorphisms (SNPs) in candidate genes CHRNA5 (rs16969968, rs17408276, rs680244) CHRNA3 (rs6495307, rs12914385) NRXN1 (rs10865246, rs1882296, rs985919) HTR2A (rs6311, rs6313) previously evaluated as genetic risk variants cigarette smoking at an early age relapse to cessation treatment Pérez-Rubio et al., 2018. These SNPs were selected due previous associations other populations, including Mexican Mestizos....