A5020160224- Blood groups and transfusion
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Immunodeficiency and Autoimmune Disorders
- Blood donation and transfusion practices
- Hemoglobinopathies and Related Disorders
- Blood disorders and treatments
- Mosquito-borne diseases and control
- Antifungal resistance and susceptibility
- Viral Infections and Vectors
- Diabetes and associated disorders
- Fungal Infections and Studies
- COVID-19 Clinical Research Studies
- Hematopoietic Stem Cell Transplantation
- Erythrocyte Function and Pathophysiology
- Parvovirus B19 Infection Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Acute Myeloid Leukemia Research
- Malaria Research and Control
- SARS-CoV-2 and COVID-19 Research
- Hepatitis Viruses Studies and Epidemiology
- Chronic Lymphocytic Leukemia Research
- Monoclonal and Polyclonal Antibodies Research
- Cytomegalovirus and herpesvirus research
- Liver Disease Diagnosis and Treatment
Biobanco del Sistema Sanitario Público de Andalucía
2021-2022
Banc de Sang i Teixits
2002-2021
Universidad de Granada
1996-2021
Andalusian Health Service
2016-2021
Ministry of Health
2021
Ayuntamiento de Sevilla
2021
Bank of Spain
2008-2020
Instituto de Investigación Biosanitaria de Granada
2020
South African National Blood Service
2017
Junta de Andalucía
2017
The recognition of pathogen-derived structures by C-type lectins and the chemotactic activity mediated CCL2/CCR2 axis are critical steps in determining host immune response to fungi. present study was designed investigate whether presence single nucleotide polymorphisms (SNPs) within DC-SIGN, Dectin-1, Dectin-2, CCL2 CCR2 genes influence risk developing Invasive Pulmonary Aspergillosis (IPA). Twenty-seven SNPs were selected using a hybrid functional/tagging approach genotyped 182...
Cases of West Nile neuroinvasive disease (WNND) in Spain increased summer 2020. Here we report on this increase and the local, regional national public health measures taken response. We analysed data from surveillance networks National Epidemiological Surveillance Network, both for human animal virus (WNV) infection. During 2020 season, a total 77 cases WNV infection (median age 65 years; 60% males) were detected south-west Spain; 72 (94%) these developed WNND, presenting as...
West Nile virus (WNV) and Usutu (USUV) circulate in several European Union (EU) countries. The risk of transfusion-transmitted (TT-WNV) has been recognized, preventive blood safety measures have implemented. We summarized the applied interventions EU countries assessed supply by compiling data on WNV positivity among donors reported TT-WNV cases. paucity infections screening results suggest that are effective. However, limited circulation presumed underrecognition or underreporting cases...
We compared the performance of SARS-CoV-2 neutralising antibody testing between 12 European laboratories involved in convalescent plasma trials. Raw titres differed almost 100-fold differences when blind-testing 15 samples. Calibration relation to reference reagent and standard curve obtained by a dilution series reduced inter-laboratory variability ca 10-fold. The harmonisation quantification is vital step towards determining protective therapeutic levels antibodies.
Tumour necrosis factor (TNF) is primarily secreted by monocytes/macrophages and activated T lymphocytes in response to fungal infections. TNF acts through receptor 1 (TNFR1) triggering a pro-inflammatory response, therefore plays pivotal role immune regulation host responses. We hypothesized that single nucleotide polymorphisms (SNPs) TNFR1 gene may influence the innate against Aspergillus. Three SNPs were genotyped 275 individuals (144 immunocompromised haematological patients with...
Of the sandfly fever viruses known to be human pathogens (serotypes Toscana [TOS], Sicilian [SFS], and Naples [SFN]), only TOS has demonstrated neurotropic activity. Infections by have been reported in Mediterranean countries, but virus was previously isolated Italy Portugal. We 15 strains of between 1988 1996 from cerebrospinal fluid patients with acute aseptic meningitis Granada, Spain. This finding led us study presence antibodies TOS, SFS, SFN 1,181 adults 87 children different regions...
Estimates of the risk transfusion-transmitted viral infections are essential for monitoring safety blood supply. The aim present study was to estimate residual blood-borne in Spain.Incidence rates seroconversion HIV, HBV, and HCV were calculated among 673,018 persons who donated more than once (repeat donors), from 1997 through 1999 at 22 donation centers (for a total 2,464,964 allogeneic donations 1,052,752 person-years).Incidence per 100,000 person-years their 95-percent CIs as follows:...
Estimates of the risk bloodborne viral infections are essential for monitoring safety blood supply and impact new screening tests. Incidence rates seroconversion residual HBV, HIV HCV were calculated among Spanish repeat donors between 1997 1999 at 22 donation centres, 7 centres 2000 2002. The per million donations was estimated to be 18.67 2.49 10.96 (between 1999). For 2000-2002 period, 9.78 2.48 3.94 HCV. Between 2003, about 3.4 tested by NAT, mainly in pools 44 donations, 12...
In Andalusia, Spain, West Nile virus (WNV) surveillance takes place from April to November, during the active vector period. Within this area seroconversion was evidenced in wild birds 2004, affecting horses and two humans for first time 2010. Since 2010, has been isolated every year horses, national regional plans have updated with epidemiological changes found. WNV is spreading rapidly throughout southern Europe caused outbreaks humans. Here we describe second outbreak three confirmed...
summary The frequencies of several human platelet antigens (HPAs) vary between different populations and are a major determinant for the prevalence HPA alloimmunization its clinical associated entities. aim this study was to characterize allele seven systems in two ethnic groups from Argentinean city Rosario, population minority Amerindian group recently arrived north country, Tobas. A total 192 healthy unrelated individuals blood donors hospital staff Hospital Italiano Garibaldi 27 Toba...
The aim of this study was to generate novel models bioartificial human oral mucosa with increased vascularization potential for future use as an advanced therapies medicinal product, by using different vascular and mesenchymal stem cell sources.Oral substitutes could contribute the clinical treatment complex diseases affecting cavity. Although several artificial have been described, biointegration is a major issue that be favored generation once grafted in vivo.Three types cells (MSCs) were...
Abstract Human neutrophil antigens (HNA) are polymorphic structures located in the membrane. The neutrophil‐specific HNA‐1a (NA1), 1b (NA2) and 1c (SH) well‐recognized allotypic forms of FcγRIIIb most frequent targets alloantibodies. aim this study was to determine gene frequencies belonging HNA‐1 system blood donors Toba Amerindians from Rosario, Argentina. Two hundred eighteen unrelated healthy Argentinean Rosario were typed for HNA‐1a, HNA‐1b HNA‐1c using polymerase chain reaction with...