A5056594222- Acute Ischemic Stroke Management
- Stroke Rehabilitation and Recovery
- Atrial Fibrillation Management and Outcomes
- Intracerebral and Subarachnoid Hemorrhage Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Multiple Sclerosis Research Studies
- Lipoproteins and Cardiovascular Health
- Venous Thromboembolism Diagnosis and Management
- Epilepsy research and treatment
- Cerebrovascular and Carotid Artery Diseases
- Vascular anomalies and interventions
- Neurogenesis and neuroplasticity mechanisms
- Neuroscience and Neuropharmacology Research
- Long-Term Effects of COVID-19
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurosurgical Procedures and Complications
- COVID-19 Clinical Research Studies
- Neurological disorders and treatments
- Cardiovascular Health and Disease Prevention
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- Intracranial Aneurysms: Treatment and Complications
- Acute Myocardial Infarction Research
- Vitamin K Research Studies
- Hormonal Regulation and Hypertension
University of Pennsylvania
2024-2025
McMaster University
2023-2024
Tehran University of Medical Sciences
2020-2024
California University of Pennsylvania
2024
Population Health Research Institute
2023
Neuroscience Institute
2022
Imam Khomeini Hospital
2022
In this study, we aimed to assess the association between development of cardiac injury and short-term mortality as well poor in-hospital outcomes in hospitalized patients with COVID-19. prospective, single-center enrolled laboratory-confirmed COVID-19 highly suspicious compatible chest computed tomography features. Cardiac was defined a rise serum high sensitivity Troponin-I level above 99th percentile (men: > 26 ng/mL, women: 11 ng/mL). A total 386 were included. present among 115 (29.8%)...
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Introduction: Carotid webs (CW) are rare shelf-like filling defects arising from the posterior wall of internal carotid artery (ICA) bulb and reportedly associated with a high risk recurrent stroke, particularly in young patients. Limited awareness understanding CW make diagnosis clinical research challenging. Methods: We searched radiology database 6 hospitals within health system between January 2021 June 2024 for reports that included “web” diagnostic impression. These were reviewed by...
Introduction: Embolic stroke of undetermined source (ESUS) may be associated with nonstenotic carotid artery plaques. Noncalcified plaque components such as intraplaque hemorrhage (IPH) well perivascular adipose tissue (PVAT) are increased risk, but the role calcifications is unclear. We examine a machine-learning approach using eXtreme Gradient Boosting (XGBoost) to classify plaques vulnerable or stable non-calcified features and calcification morphology. Methods: Patients neck CT...
Abstract Background and Aims Primary percutaneous coronary intervention (PCI) is the treatment of choice in ST‐elevation myocardial infarction (STEMI) patients. This study aims to evaluate predictors in‐hospital long‐term mortality among patients with STEMI undergoing primary PCI. Methods In this registry‐based study, we retrospectively analyzed PCI enrolled angioplasty registry Sina Hospital. Independent were determined using multivariate logistic regression Cox analyses, respectively....
Cognitive impairment (CI) and executive dysfunction (ED) are prevalent in patients with multiple sclerosis (PwMS). The Minimal Assessment of Function Multiple Sclerosis (MACFIMS) is the gold standard neuropsychological battery (NPB) for detecting CI. Delis-Kaplan Executive System (DKEFS) NPB evaluates ED. We aimed to find practical test(s) from DKEFS acceptable diagnostic utility early detection cognitive domains.Cognitive tasks, physical disability, depression scores 30 PwMS were assessed...
Cerebral microbleeds are magnetic imaging resonance (MRI) markers of hemorrhage-prone cerebral small vessel disease that predict future risk ischemic stroke and intracranial hemorrhage (ICrH). There exist concerns about the net benefit antithrombotic therapy in patients with microbleeds. We aimed to investigate effects an oral factor-XIa inhibitor (asundexian), is hypothesized inhibit thrombosis without compromising hemostasis, on development new over time interactions between asundexian...
Atrial fibrillation is the most common arrhythmia in adults and its prevalence growing rapidly. It has been shown that AF associated with increased risk of heart failure, ischemic hemorrhagic stroke, mortality. Hence, there interest among researchers seeking preventive therapeutic interventions regarding AF. In recent decades, it suggested statins may decrease incidence also recurrence after cardioversion catheter ablation. These effects are thought to be mediated by different mechanisms...
Introduction: Cerebral microbleeds are reported to predict risk of hemorrhagic transformation (HT) in patients with acute ischemic stroke. We aimed investigate whether the effect dabigatran (vs. aspirin) minor non-cardioembolic stroke/TIA is modified by baseline on MRI. Methods: This a post hoc analysis DATAS-II trial that randomized 305 (150/110 mg twice daily) or aspirin (81 for 30 days. MRIs T2*-weighted sequences their scans underwent blinded central adjudication microbleeds. Results: A...
Introduction: Up to 40% of ICH patients have unknown onset time, leading uncertainty regarding the use hyperacute treatments and their exclusion from acute treatment trials. We aimed develop a prediction score that can reliably identify presenting within 3 hours symptom onset. Methods: Spontaneous participating in iDEF trial with available prerequisite data were analyzed. A stepwise multivariable logistic regression model was used determine predictors early presentation (symptom...
Embolic stroke of undetermined source (ESUS) may be associated with carotid artery plaques <50% stenosis. Plaque vulnerability is multifactorial, possibly related to intraplaque hemorrhage (IPH), lipid-rich-necrotic-core (LRNC), perivascular adipose tissue (PVAT), and calcification morphology. Machine-learning (ML) approaches in plaque classification are increasingly popular but often limited clinical interpretability by black-box nature. We apply an explainable ML approach, using...
Abstract Background and objectiveDoor-to-needle (DTN) time is an important factor in stroke settings for which studies have reported delays women, resulting worse outcomes. We aimed to evaluate whether our modified algorithm could reduce sex disparities, especially DTN.MethodsThis longitudinal cohort study was conducted between September 1, 2019, August 31, 2021, at a comprehensive center. Previously we utilized the conventional “D’s of stoke care” timely management. The “modified 8 D’s...
Abstract Introduction: Door-to-needle (DTN) time is an important factor in managing stroke for which studies have reported delays women. We aimed to evaluate the effect of some simple modifications on reducing sex disparities, with a focus DTN. Methods: This longitudinal cohort study was conducted between September 2019, and August 2021, at comprehensive center. Previously we utilized conventional “D’s stoke care” timely management. Some were implemented 2020, special neurologist's...
Background: Door-to-needle (DTN) is the duration between patient’s arrival at hospital and receiving intravenous thrombolysis in ischemic stroke settings, for which studies have reported delays women. The “D’s of care” describes 8 steps (D1 to D8) patients’ time tracker. We implemented simple modifications by splitting D4 D6 into these substeps: emergency room (D4-A), early assessment a neurologist (D4-B), decision on eligibility receive recombinant tissue plasminogen activator (D6-A),...
Background: The prevalence of cognitive impairment among patients with epilepsy is about 70%. There still no approved medication for the treatment this problem. Objectives: present study aims to assess safety and efficacy memantine in improving function epilepsy. Materials & Methods: This a pilot, randomized, double-blind, placebo-controlled, parallel-group clinical trial, conducted hospital Tehran, Iran during 2018-2019. Participants were randomly allocated receive (5 mg/day first eight...
Medically refractory seizures affect one-third of patients with epilepsy (PwE), for whom surgery is considered. Video electroencephalography (vEEG) monitoring a fundamental tool pre-operative seizure localization. Facial and cranial myogenic artifacts can obscure vEEG findings, thus interfering Studies have shown the beneficial effects botulinum toxin type A (BTX-A) injection into muscles reducing artifacts. This longitudinal study aimed to assess BTX-A on these Twenty-two medically...