A5053290360- Epilepsy research and treatment
- Migration, Health and Trauma
- Ethics and Legal Issues in Pediatric Healthcare
- Pharmacological Effects and Toxicity Studies
- Global Health Workforce Issues
- Child Nutrition and Feeding Issues
- Food Security and Health in Diverse Populations
- Psychiatric care and mental health services
- Childhood Cancer Survivors' Quality of Life
- Pharmaceutical studies and practices
- Ethics in Clinical Research
- Breastfeeding Practices and Influences
- Emergency and Acute Care Studies
- Primary Care and Health Outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Forensic Toxicology and Drug Analysis
- Anesthesia and Sedative Agents
- Antibiotics Pharmacokinetics and Efficacy
- Health Sciences Research and Education
- Innovations in Medical Education
- Health and Medical Research Impacts
- Medical Malpractice and Liability Issues
- Dental Education, Practice, Research
- Posttraumatic Stress Disorder Research
- Grief, Bereavement, and Mental Health
University of Liverpool
2017-2020
Alder Hey Children's NHS Foundation Trust
2017-2020
MRC Clinical Trials Unit at UCL
2019
Grady Health System
1998
Emory University
1998
University Hospital of North Tees
1994
Phenytoin is the recommended second-line intravenous anticonvulsant for treatment of paediatric convulsive status epilepticus in UK; however, some evidence suggests that levetiracetam could be an effective and safer alternative. This trial compared efficacy safety phenytoin management epilepticus.This open-label, randomised clinical was undertaken at 30 UK emergency departments secondary tertiary care centres. Participants aged 6 months to under 18 years, with requiring treatment, were...
Background: The purpose of this study was to describe the relationship between breastfeeding intention among socioeconomically disadvantaged pregnant women and maternal demographics, previous experience, social support. Methods: A cross‐sectional, convenience sampling strategy employed for data collection. Low‐income ( n = 1001) in a public hospital completed six‐page questionnaire about their infant feeding plans, Simple regression analyses were conducted compare with hypothesized...
Convulsive status epilepticus (CSE) is the most common life-threatening neurological emergency in childhood. These children are also at risk of significant morbidity, with acute and chronic impact on family health social care systems. The current recommended first-choice, second-line treatment aged 6 months above intravenous phenytoin (fosphenytoin USA), although there a lack evidence for its use it associated side effects. Emerging suggests that levetiracetam may be effective as agent CSE,...
This study applied the Transtheoretical Model and Theory of Reasoned Action to understanding intention initiate breastfeeding among socioeconomically disadvantaged pregnant women. Study objectives included: (1) assessing feasibility using two theories explain (2) examining inter-relationships between regarding intention. A theoretically based examination factors related could lead improved promotion strategies. article examines preliminary development a relatively reliable instrument for...
Background Convulsive status epilepticus is the most common neurological emergency in children. Its management important to avoid or minimise morbidity and death. The current first-choice second-line drug phenytoin (Epanutin, Pfizer Inc., New York, NY, USA), for which there no robust scientific evidence. Objective To determine whether levetiracetam (Keppra, UCB Pharma, Brussels, Belgium) more clinically effective intravenous treatment of paediatric convulsive help better inform its...
Asylum seekers and refugees (AS&Rs) experience impaired mental health wellbeing, related to stresses in their country of origin, experiences transit reception on arrival, including significant barriers accessing mainstream services. Their contact with care is often crisis-driven mediated through non-governmental organisations (NGOs). Problem Management Plus (PM+) a psychosocial intervention recommended by the World Health Organisation address distress experienced adults affected humanitarian...
EcLiPSE (Emergency treatment with Levetiracetam or Phenytoin in Status Epilepticus children) is a randomised controlled trial (RCT) the United Kingdom. Challenges to success include need immediately administer an intervention without informed consent and changes staffing during conduct, mainly due physician rotations. Using literature on parents' perspectives research prior (RWPC) guidance, we developed interactive training package (including videos, simulation question answer sessions)...
Alternatives to prospective informed consent enable the conduct of paediatric emergency and critical care trials. Research without prior (RWPC) involves practitioners approaching parents after an intervention has been given seeking for their child continue in trial. As part embedded study 'Emergency treatment with Levetiracetam or Phenytoin Status Epilepticus children' (EcLiPSE) trial, we explored how described trial RWPC during recruitment discussions, well this information was understood...
Key challenges to the successful conduct of The Emergency treatment with Levetiracetam or Phenytoin in Status Epilepticus children (EcLiPSE) trial were identified at pre-trial stage. These included practitioner anxieties about conducting research without prior consent (RWPC), inexperience an ED-led and use a medication that was not usual ED practice. As part embedded study, we explored parent experiences recruitment, RWPC inform design future trials.
The case history presented illustrates that, following an overdose of 'Whizz' and alcohol, a protracted dystonic syndrome can develop, clinically indistinguishable from tetanus. A prolonged period ventilation may be necessary, but, in this case, complete recovery eventually occurred.
Abstract Background Asylum seekers and refugees (AS&Rs) experience impaired mental health wellbeing, related to stresses in their country of origin, experiences transit reception on arrival, including significant barriers accessing mainstream services. Their contact with healthcare is often crisis-driven mediated through non-governmental organisations (NGOs). Problem Management Plus (PM+) a psychosocial intervention recommended by the World Health Organization address distress...
<h3>Aims</h3> Challenges to the success of 'The Emergency treatment with Levetiracetam or Phenytoin in Status Epilepticus children (EcLiPSE)' trial included: practitioner anxieties about research without prior consent ('deferred consent'), including how parents would react being informed their child had already been randomised into trial; inexperience conducting an Department led a paediatric neurological emergency; and use anti-epileptic medication (Levetiracetam), which was not standard...
Abstract Background Asylum seekers and refugees (AS&Rs) experience impaired mental health wellbeing, related to stresses in their country of origin, experiences transit reception on arrival, including significant barriers accessing mainstream services. Their contact with healthcare is often crisis-driven mediated through non-governmental organisations (NGOs). Problem Management Plus (PM+) a psychosocial intervention recommended by the World Health Organization address distress...