A5012745373- Endoplasmic Reticulum Stress and Disease
- Regulation of Appetite and Obesity
- Cardiovascular Disease and Adiposity
- RNA regulation and disease
- Diet and metabolism studies
- Advanced MRI Techniques and Applications
- Eating Disorders and Behaviors
- Advanced Neuroimaging Techniques and Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Neonatal and fetal brain pathology
- Alzheimer's disease research and treatments
- Spine and Intervertebral Disc Pathology
- Glioma Diagnosis and Treatment
- Musculoskeletal pain and rehabilitation
- Medical Imaging and Analysis
- Functional Brain Connectivity Studies
- Meningioma and schwannoma management
- MXene and MAX Phase Materials
- Neurological and metabolic disorders
- Neurofibromatosis and Schwannoma Cases
- Adipokines, Inflammation, and Metabolic Diseases
- Pain Mechanisms and Treatments
- Retinal Development and Disorders
- HIV-related health complications and treatments
- Neurological Complications and Syndromes
Washington University in St. Louis
2019-2024
Oregon Health & Science University
2023
Mallinckrodt (United States)
2023
Mallinckrodt (Ireland)
2023
St. Louis Children's Hospital
2022
Arkansas Children's Nutrition Center
2018-2020
An-Najah National University
2016-2020
University of Arkansas for Medical Sciences
2018
National University Hospital
2016
Human obesity is associated with low-grade chronic systemic inflammation, alterations in brain structure and function, cognitive impairment. Rodent models of show that high-calorie diets cause inflammation (neuroinflammation) multiple regions, including the hippocampus, impairments hippocampal-dependent memory tasks. To determine if similar effects exist humans obesity, we applied Diffusion Basis Spectrum Imaging (DBSI) to evaluate neuroinflammation axonal integrity. We examined...
Abstract Neuroinflammation is both a consequence and driver of overfeeding weight gain in rodent obesity models. Advances magnetic resonance imaging (MRI) enable investigations brain microstructure that suggests neuroinflammation human obesity. To assess the convergent validity across MRI techniques extend previous findings, we used diffusion basis spectrum (DBSI) to characterize obesity-associated alterations 601 children (age 9–11 years) from Adolescent Brain Cognitive DevelopmentSM Study....
Obesity is related to quantitative neuroimaging abnormalities including reduced gray matter volumes and impaired white microstructural integrity, although the underlying mechanisms are not well understood. We assessed influence of obesity on neuroinflammation imaging that may mediate brain morphometric changes. Establishing role in will enhance understanding this modifiable disorder as a risk factor for Alzheimer's disease (AD) dementia. analyzed MRIs from 104 cognitively normal participants...
Metabolic syndrome (MetS) is one of the main reasons for elevated cardiovascular morbidity and mortality worldwide. Obese overweight individuals are at high risk developing these chronic diseases. The aim this study was to characterize establish sex-adjusted prevalence metabolic its components.A cross-sectional conducted in 2015, 689 (329 men 360 women) aged 18-65 years from three refugee camps West Bank. International Diabetes Federation modified National Cholesterol Education Program-Third...
Wolfram syndrome is a rare genetic disease with characteristic brain involvement. We reviewed the MR images of patients to determine frequency and characteristics common neuroradiologic findings.We retrospectively imaging data genetically-confirmed who had been recruited Washington University Syndrome Research Clinic. These were evaluated between 2010 2019 annual MRIs, along other measures. assessed for clinical signs at each individual's first last follow-up visits characterize frequency,...
Understanding how normal weight and obese young children process high-calorie food stimuli may provide information relevant to the neurobiology of eating behavior contributing childhood obesity. In this study, we used fMRI evaluate whether brain activation images differs between children. Brain maps in response non-food for 22 healthy, 8–10-years-old (N = 11/11 weight/obese respectively) were generated compared groups. When comparing differences viewing versus children, group observed areas...
Abstract Objective Basal ganglia regions are part of the brain’s reward‐processing networks and implicated in neurobiology obesity eating disorders. This study examines basal microstructural properties adults with without obesity. Methods Diffusion basis spectrum imaging (DBSI) images were analyzed to obtain putative markers neuroinflammation. Relationships between DBSI metrics reward sensitivity behaviors also explored. Results A total 46 participants (25 people obesity; aged 20‐40 years;...
The complex function of memory has been linked to both brain gray and white matter (WM). WM abnormalities are associated with impairment in pathological conditions. We investigated whether variation microstructure healthy children also correlates performance.Sixty-five 7.5 8.5-year-old had a MRI scan using diffusion tensor imaging (DTI). They were assessed for performance the Children's Memory Scale (CMS). Eight indices that evaluate verbal visual (immediate delayed) measured. DTI parameters...
Posterior reversible encephalopathy syndrome (PRES) is a clinical and radiological entity of acute neurological symptoms associated with characteristic MRI finding. Vasogenic edema in the white matter parieto-occipital regions classical findings. Spinal cord involvement PRES extremely rare frequently underrecognized condition. Recently, variant-type isolated infratentorial structures getting more attention. Herein, we present case hypertensive emergency features brain stem, cerebellum, spinal cord.
Langerhans Cell Histiocytosis (LCH) is a rare disorder characterized by neoplastic proliferation of Langerhans-type dendritic cells. LCH most frequently encountered in the pediatric populations, and involvement skeletal system common manifestation. Herein, we report case presented as an isolated skull lesion 66-year-old patient. This presentation has never been reported literature at this advanced age suggests that, despite being exceptionally rare, clinicians should consider differential...
The hippocampus is a frequent focus of quantitative neuroimaging research, and structural hippocampal alterations are related to multiple neurocognitive disorders. An increasing number studies focusing on subfield regional involvement in these disorders using various automated segmentation approaches. Direct comparisons among approaches limited. purpose this study was compare the agreement between two algorithms an adult population.We compared results 2 for subfields (FreeSurfer v6.0...
Abstract Neuroinflammation is both a consequence and driver of overfeeding weight gain in rodent obesity models. Advances magnetic resonance imaging (MRI) enable investigations brain microstructure that suggests neuroinflammation human obesity. To assess the convergent validity across MRI techniques extend previous findings, we used diffusion basis spectrum (DBSI) to characterize obesity-associated alterations 601 children (age 9-11 years) from Adolescent Brain Cognitive Development SM...
Objective This study determined whether striatal dopamine (DA) release is affected by food ingestion and the DA response to high‐calorie images greater in fasted than fed state people with obesity. Methods Striatal was evaluated 10 obesity prediabetes after consuming a meal satiation fasting overnight as well viewing of compared low‐calorie foods or using positron emission tomography [ 11 C]raclopride injection. Results D2/D3 receptor availability not different during conditions. Viewing...
Peters' anomaly is a rare congenital eye condition characterized by anterior segment dysgenesis and commonly presents as unilateral or bilateral corneal opacity in the early neonatal period. often associated with brain skull abnormalities, which are frequently overlooked. In this paper, we present case of 5-day-old female neonate anomaly, review literature for similar reports that describe imaging findings. our case, studies show abnormalities involving segments both globes absent...
Background Well-conducted meta-analyses are considered to be at the top of evidence-based hierarchy pyramid, with an expansion these publications within cardiovascular research arena. There limited data evaluating trends and quality such publications. The objective this study was evaluate methodological rigor temporal medicine-related published in highest impact journals. Methods Results Using Medline database, we retrieved systematic reviews