Abstract Background The association between dental status and mortality in community-dwelling older adults has been documented by several studies. aim of this study was to analyze the contribution self-assessed chewing ability, number remaining teeth serum albumin levels interactions three factors. Methods A 20-year follow-up conducted with 666 subjects aged 80 years (from 1996 2017) who resided 8 areas served one health center Iwate Prefecture. Health check-ups including physical fitness...

Poor oral hygiene during pregnancy is associated with pre-term birth, low birth weight, and pregnancy-induced hypertension, suggesting its significant effects on both maternal fetal health. However, global guidelines indicate that care remains an underdeveloped field, no large-scale reports dental studies conducted exist in Japan. Therefore, we assessed the key factors contribute to maintaining health a cohort of Japanese women. We examinations 907 pregnant women Matsudo City, Japan,...

Osteoclasts are bone-specific multinucleated cells generated by the differentiation of monocyte/macrophage lineage precursors. Regulation osteoclast is considered an effective therapeutic approach to treatment bone-lytic diseases. Periodontitis inflammatory disease characterized extensive bone resorption. In this study, we investigated effects sodium fluoride (NaF) on osteoclastogenesis induced Porphyromonas gingivalis, important colonizer oral cavity that has been implicated in...

Dental professionals are at increased risk of being infected with airborne pathogens such as SARS-CoV-2 because they often exposed to droplets/aerosols production during dental treatment. To scientifically clear the effects extraoral and oral suctions on droplets aerosols produced by treatments using an ultrasonic scaler was analyzed. The adenosine triphosphate bacteria in simulated scaling were quantitatively observed reactions luciferin/luciferase incubation culture plates grow bacteria,...

Abstract Background/Aims Lacerations of the oral mucosa and fractures alveolar processes commonly occur in traumatic dental injuries (TDIs). Impaired wound healing tissue regeneration have severe consequences on quality life. Bone marrow mesenchymal stem cells (BMMSCs) possess ability self‐renewal multipotential differentiation. Treatment with low‐level sodium fluoride (NaF) has emerged as a promising approach to enhance repair. The aim this study was assess effects NaF soft proliferation,...

Quality of life (QOL) and mortality are true endpoints epidemiological or medical research, especially for community-dwelling older adults. Nutritional status activities daily living (ADLs) associated with QOL mortality. Good oral health supports a good nutritional status. The aim this study was to elucidate the complex structure these important health-related factors. We surveyed 354 healthy adults at age 85. evaluated by serum level albumin. QOL, ADLs, self-assessed chewing ability,...

The oral microbiome of healthy older adults has valuable information about a microbiome. In this study, we collected and analyzed the denture plaque tongue coating samples from four female centenarians. After DNA extraction purification, pyrosequencing V3–V4 hypervariable regions 16S rRNA was carried out. bacterial taxonomy for each lead assigned based on search EzBioCloud database. We obtained total 199,723 valid, quality-controlled reads 210,750 coating. were 407 operational taxonomic...

Phenytoin (PHT)‑induced gingival overgrowth is caused by the increased proliferation and reduced apoptosis of fibroblasts in inflammatory gingiva. Licorice has long been used as a component therapeutic preparations. It inhibits cell proliferation, induces anti‑inflammatory effects. 18‑α‑glycyrrhetinic acid (18α‑GA), active compound licorice, promotes various types cells. The present study determined whether 18α‑GA affects exposed to PHT. aimed establish basis for application treat induced...

Since 1998, the authors have been working to improve oral health of children at kindergartens and primary schools in Kingdom Tonga (Tonga). Our activity has a school-based fluoride mouth-rinsing (FMR) program. FMR is performed using 7-10 mL 0.2% NaF solution for 1 min once per week each school. In present study, we evaluated effect on dental caries incidence among Tongan schoolchildren. A total 109 aged 10 years were six Tongatapu Island. The group comprised 46 who had participated program...

Objective In this study, we investigated the role of phenytoin ( PHT ) in death receptor‐induced apoptosis gingival fibroblasts to clarify mechanism ‐induced overgrowth. Methods Human were cultured semiconfluence and treated with (0.025, 0.1, 0.25, 1.0 μ M) for 48 h, then, apoptotic cell numbers relatively determined by absorptiometry. After 24 h 0.25 M treatment, caspase activity was measured absorptiometry, cycle phase distribution analyzed flow cytometry, expression levels genes...

Brushing with a toothbrush is effective for removing oral biofilms. However, toothbrushes can be source of infectious diseases after use. Recently, the environmental impacts plastics, such as marine pollution, have become an issue. This includes disposal plastic toothbrushes. Consequently, bamboo toothbrushes, low impact, widely-used alternatives. Although there are many reports on hygiene use, few Thus, we compared those and biomass use storage. Three types were immersed in bacterial...

Lactobacillus crispatus KT-11, which was originally isolated from the feces of healthy infants, has been reported to show multiple immunoregulatory effects. However, there have no reports about effect on periodontal disease, a chronic destructive inflammatory disease tissues supporting teeth. We used model in mice were infected with Porphyromonas gingivalis. As we report here, oral ingestion KT-11 exerted inhibitory effects alveolar bone resorption this model, suggesting potential preventive...

Mortality is obviously intended for epidemiological studies of community-dwelling older adults. There are several health-related factors associated with nutritional status and mortality. The aim this study was to elucidate the risk factor mortality in oldest-older adults at age 90 clarify structure A 10-year follow-up performed 93 subjects 90. mean median their survival days were 2373 2581 women, 1694 1793 men. By Cox's proportional hazards model, self-assessed chewing ability, activities...

Autophagy is a highly conserved intracellular digestion process that degrades damaged proteins and organelles but the biological roles of autophagy in pathological aspects oral tissues remain largely unknown. We sought to elucidate function autophagy, especially its interplay with apoptosis oxidative stress, toxicity induced by exposure 5 mM sodium fluoride (NaF). Human cementoblasts (HCEM-2) culture were exposed NaF for min, after which cell viability assessed using MTS assay an Annexin...

Background: Public oral health surveys have shown that the prevalence of dental caries in adults is increasing worldwide, resulting increased workload and costs other clinical services. Total streptococci are broadly grouped into mutans three species. They constitute a majority bacteria found mouth. Of total streptococci, group primarily causes which consists seven Streptococcus (S. mutans) streptococcus most strongly associated with caries. To date, no simple assay (kit) has been developed...

Candidiasis of the oral mucosa arises chiefly as a re- sult infection with Candida albicans. Many clinico- pathological analyses macroscopic findings have been described, although clinical candidiasis vary considerably and conditions are complex. The present study analyzes distribution, clinical, cytological histological diagnoses candidiasis, associated complex diseases di-agnostic value cytology. ratio in-fection was 28.9% among 1551 participants. Females were infected significantly more...

The South Pacific Medical Team, a voluntary group organized by Japanese dentists, has worked to improve oral health in the Kingdom of Tonga since 1998. Its main activity is planning and administration school-based program known as MaliMali Program.The Program been promoted Tongan team for preventive dentistry from Dental Office Ministry Health. In present study, we describe results consider its effects 1998 2009.The consists following three programs, plus additional activities: an education...

Background:The aim of this study was to evaluate the association between dental caries and concomitant infections Streptococcus mutans (S. mutans) sobrinus sobrinus) according ratio cariogenic bacteria in plaque samples from adults obtain basic data develop clinical chairside culture assay (kits) for assessment risk. Methods Materials:Plaque 192 adult volunteers (age range, 20-28 years) were obtained using sterile toothbrushes.Caries history number decayed, missing, filled (DMF) teeth...

Objectives: Cyclosporine A promotes gingival fibrosis by enhancing the proliferation of fibroblasts, leading to overgrowth. The population fibroblasts is regulated cell cycle machinery, which balances growth and inhibition. Cells that detect DNA damage pause at G1/S checkpoint repair instead progressing S phase. Previous studies have linked drug-induced overgrowth response lipopolysaccharide (LPS) cyclosporine A. This research investigates effects on its mediators in LPS-treated clarify...

Gingival overgrowth caused by cyclosporine A is due to increased fibroblast proliferation in gingival tissues. Cell cycle system balances and anti-proliferation of fibroblasts plays a role the maintenance its population When cells detect respond abnormalities (e.g. DNA damage), cell progression arrested G 1 phase until completion damage restoration. In this study, we investigated effects on arrest regulators clarify mechanism A-induced overgrowth. Human from healthy donors were cultured...

Since 1972, community water fluoridation programs have not been practiced in Japan. Risk perception among the population plays an important role implementation of programs. The oral health behavior Japanese children has changed, especially due to recent increases use fluoridated products and fluoride applications by dentists. purpose this study was examine associations between behavior, risk perception, desire implement residents. We distributed a questionnaire survey (response rate: 92.8%)...

A decrease in oral function is a risk factor for aspiration pneumonia and suffocation, leading to reduction physical malnutrition at elderly people.. Therefore, there need develop simple method improve older adults, including those requiring long-term care. This study aimed elucidate the effects of chewing gum mastication training habitation on environment, eating habits residents users facility. Subjects were randomly assigned two groups, intervention control groups. The group consisted 28...

The use of high-volume intra-oral suction(HVIOS)is effective in reducing droplets and aerosols during dental treatment. However, there are few reports on the effects different uses HVIOS aerosols. We examined differences generation with HVIOS. teeth were scaled ground. number associated was evaluated by settle plate sampling, aerosol particle measurement, high-speed camera photography. bacterial colonies front dentist significantly reduced when a placed at left side mouth compared to it not...