A5013512585- Oral microbiology and periodontitis research
- Stress Responses and Cortisol
- Bone and Dental Protein Studies
- Endodontics and Root Canal Treatments
- Immune Response and Inflammation
- Bone Metabolism and Diseases
- Antimicrobial Peptides and Activities
- Plant-based Medicinal Research
- Connexins and lens biology
- Bone and Joint Diseases
- Hypothalamic control of reproductive hormones
- Circadian rhythm and melatonin
- Neuroendocrine regulation and behavior
- Bone health and treatments
- Adrenal Hormones and Disorders
- Biochemical Analysis and Sensing Techniques
- Geological formations and processes
- Amino Acid Enzymes and Metabolism
- Oral and Maxillofacial Pathology
- Geology and Paleoclimatology Research
- Advanced Chemical Sensor Technologies
- Dental Research and COVID-19
- Bioactive Compounds and Antitumor Agents
- Remote Sensing and LiDAR Applications
- Numerical methods in inverse problems
Kanagawa Dental University
2011-2022
The University of Tokyo
1957-2016
Teikyo University
1996-2011
University of California, San Francisco
1975
Hokkaido University
1969-1970
National Institute of Infectious Diseases
1957-1960
The purpose of this study was to characterize blood-brain barrier (BBB) transport oxycodone, a cationic opioid agonist, via the pyrilamine transporter, putative organic cation using conditionally immortalized rat brain capillary endothelial cells (TR-BBB13). Oxycodone and [<sup>3</sup>H]pyrilamine were both transported into TR-BBB13 in temperature- concentration-dependent manner with <i>K</i><sub>m</sub> values 89 28 μM, respectively. initial uptake oxycodone significantly enhanced by...
Central and peripheral humoral responses of the adrenocortical system were measured for 2 h after application several stimuli. Two min onset stressesof shamadrenalectomy or laparotomy with intestinal traction there was a 4-6-fold increase inhypothalamic CRF content as compared to control content. This is usual response stress. In contrast, adrenalectomy manipulation pedicles adrenal glands, at only slightly increased above baseline values. finding suggests that touching vascular nervous...
The postnatal development of circadian rhythm and stress-induced changes in hypothalamic corticotropin-releasing activity (CRF) was studied the rat. CRF estimated by method direct intrapituitary microinjection. It found that a became evident between 14th 21st day life, whereas responsiveness to stress as early 7th day. Thus, dissociation onset time stressinduced clearly shown, indicating initiation ACTH secretion is different mechanism 2 cases. Furthermore, it suggested may at least be one...
Osteoclasts are bone-specific multinucleated cells generated by the differentiation of monocyte/macrophage lineage precursors. Regulation osteoclast is considered an effective therapeutic approach to treatment bone-lytic diseases. Periodontitis inflammatory disease characterized extensive bone resorption. In this study, we investigated effects sodium fluoride (NaF) on osteoclastogenesis induced Porphyromonas gingivalis, important colonizer oral cavity that has been implicated in...
Postnatal development of circadian rhythm the hypothalamo-pituitary-adrenocortical axis was examined by sacrificing rats twice a day, i. e., 8: 30 a.m. and 6: p.m. Circadian plasma corticosterone level became evident during third week life. Hypothalamic content corticotropin-releasing factor (CRF) not detectable till end second after birth. A significant increase CRF activity manifested in evening postnatal life, whereas morning remained undetectable. Thus, it is apparent that hypothalamic...
In this study, a Porphyromonas gingivalis (P.g.)-infected mouse periodontitis model was used to investigate the effect of omega-3 fatty acid intake on differentiation and maturation cultured osteoclast. Four-week-old C57BL/6JJcl mice were divided into four groups according diets they fed from beginning experiment (i.e., food containing or omega-6 acids) whether orally administered P.g. Thirty-three days after experiment, bone marrow cells sampled femoral each group differentiated...
An attempt was made to detect diurnal periodicity in the hypothalamic content of corticotropin-releasing factor (CRF) activity normal pigeon (Columba livia) employing intrapituitary microinjection method. It found that CRF hypothalamus exhibits a typical rhythm, with its peak value at 6 a.m. and trough 8 p.m. under lighting regimen 12-h light dark daily cycle. Moreover, this rhythm shown be well correlated plasma corticosterone level definite phase shift. These findings support concept...
Variation of the hypothalamic CRF activity following various stressful stimuli was examined in normal and adrenalectomized rats by use intrapituitary microinjection method. Following were used such as systemic injections vasopressin, epinephrine histamine or exposure to ether vapor plus laparotomy, formalin gas, noise strong light a strange environment. In spite postulated difference among these stimuli, animals responded rather uniformly with an increment median eminence, although magnitude...
It is important to understand the onset of periodontal disease in terms bacterial infection and host factors. Host-bacteria interactions can be elicited human cultured cells animal models, but these models provide only limited biological information about reactions against attacks. Development an vivo model using gingival tissue needed. We established nu/nu mice evaluated defense following gingiva. Human samples were collected from periodontitis patients transplanted mouse subdermis. After 2...
Abstract Objectives In this study, we aimed to evaluate the bactericidal effect and cytotoxicity of an ethylenediaminetetra-acetic acid (EDTA)-based root canal irrigant solution capable efficiently removing both organic matter smear layer. We prepared a strong alkaline EDTA (AE) with buffer capacity similar that sodium hypochlorite. Materials Methods AE was used at concentrations 1%, 2%, 3%. The on Enterococcus faecalis evaluated by determining colony number biofilm removal rate. Biofilms...
The effects of electrical stimulation the lateral hypothalamic area (LHA), periventricular arcuate nucleus (ARC) and ventromedial (VMH) on rates 14C transfer from 14C-1 acetate into ovarian steroids in slices hypophysectomized adrenalectomized (H-A) rats were investigated. estrogen 20 alpha-hydroxypregn-4-en-3-one (20 alpha-OH-P) decreased by LHA stimulation. ARC VMH increased estrogen, progesterone alpha-OH-P. From these results, it might be suggested that structures involved regulation...