A5100612466- Blood groups and transfusion
- RNA modifications and cancer
- Retinoids in leukemia and cellular processes
- Immune Cell Function and Interaction
- Cancer-related molecular mechanisms research
- interferon and immune responses
- RNA Research and Splicing
- Histone Deacetylase Inhibitors Research
- Complement system in diseases
- Virus-based gene therapy research
- Cytokine Signaling Pathways and Interactions
- Hematological disorders and diagnostics
- Hematopoietic Stem Cell Transplantation
- Hemoglobin structure and function
- Polyomavirus and related diseases
- Protein Degradation and Inhibitors
- Signaling Pathways in Disease
- Kawasaki Disease and Coronary Complications
- Bone Metabolism and Diseases
- Extracellular vesicles in disease
- Cardiovascular Issues in Pregnancy
- Blood disorders and treatments
- Acute Myeloid Leukemia Research
- Reproductive System and Pregnancy
- Mechanical Circulatory Support Devices
Tianjin Medical University General Hospital
2007-2025
Tianjin Medical University
2007-2018
Myelodysplastic syndromes (MDS) represent a heterogeneous group of clonal hematopoietic disorders characterized by ineffective haematopoiesis, refractory cytopenia, and an increased risk progression to acute myeloid leukaemia. This study investigates the presence cellular senescence in bone marrow (BM) CD235a+ erythrocyte precursors MDS patients explores its correlation with anaemia. We assessed senescence-related markers cell cycle distribution BM patients. Correlation analyses were...
Abstract Recent research showed that invariant natural killer T ( iNKT ) cells take part in the regulation of osteoclastogenesis. While role myeloma bone disease MBD remains unclear. In our study, quantity and levels cytokines produced by them were measured flow cytometry. osteoclasts induced from peripheral blood mononuclear after activation α‐GalCer or RANKL vitro. Then, gene expressions determined RT ‐ PCR ELISA , respectively. The results production IFN ‐γ significantly decreased newly...
Topic: 11. Bone marrow failure syndromes incl. PNH - Biology & Translational Research Background: On the basis of our previous studies, we found that SUZ12 participate in proliferation clone by regulating H3K27me3. And then used immunoprecipitation and mass spectrometry to identify MIB2 interacting with SUZ12. Aims: We explore mechanism clones. hope improve pathogenesis a new target. Methods: have constructed PIGA gene knock-out K562 cell line(K562-KO) CRISPR/cas9. Immunoprecipitation were...