A5024019433- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Nicotinic Acetylcholine Receptors Study
- Photoreceptor and optogenetics research
- Eosinophilic Disorders and Syndromes
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Receptor Mechanisms and Signaling
- Chronic Kidney Disease and Diabetes
- Pharmacological Effects and Toxicity Studies
- Heme Oxygenase-1 and Carbon Monoxide
- Angiogenesis and VEGF in Cancer
- Dialysis and Renal Disease Management
- Polyomavirus and related diseases
- Platelet Disorders and Treatments
- Chronic Myeloid Leukemia Treatments
- Psoriasis: Treatment and Pathogenesis
- Viral-associated cancers and disorders
- Heparin-Induced Thrombocytopenia and Thrombosis
- Apelin-related biomedical research
- Atherosclerosis and Cardiovascular Diseases
- Alcoholism and Thiamine Deficiency
- Traumatic Brain Injury and Neurovascular Disturbances
- Antifungal resistance and susceptibility
- Cancer Immunotherapy and Biomarkers
- Kidney Stones and Urolithiasis Treatments
- Renal and Vascular Pathologies
Hôpital Necker-Enfants Malades
2021-2024
Assistance Publique – Hôpitaux de Paris
2021-2024
Paris Cardiovascular Research Center
2024
Inserm
2018-2024
Bicêtre Hospital
2020-2024
Neurosciences Paris-Seine
2018
Sorbonne Université
2018
Institut de Biologie Paris-Seine
2018
Centre National de la Recherche Scientifique
2018
Abstract Background Recreational nitrous oxide (N 2 O) use has become more widespread worldwide, leading to an increase in myelopathies and peripheral neuropathies. The aim of this study was describe clinical socioeconomical characteristics severe N O-induced (NI) neurological disorders (NI-NDs), determine its incidence the Greater Paris area compare it with that similar inflammatory disorders. Methods We performed a retrospective multicentric cohort all adult patients NI-NDs neurology...
Dopamine (DA) neurons of the ventral tegmental area (VTA) integrate cholinergic inputs to regulate key functions such as motivation and goal-directed behaviors. Yet temporal dynamic range mechanism action acetylcholine (ACh) on modulation VTA circuits reward-related behaviors are not known. Here, we used a chemical-genetic approach for rapid precise optical manipulation nicotinic neurotransmission in living mice. We provide direct evidence that ACh tone fine-tunes firing properties DA...
Primary hyperoxaluria is a rare autosomal recessive genetic disorder due to impaired glyoxylate liver metabolism resulting in the accumulation of oxalate. Three types are described with wide range severity. Type 1 primary most common, caused by mutations alanine-glyoxylate aminotransferase (AGXT) gene. This results recurrent nephrolithiasis and nephrocalcinosis from childhood early adulthood, development chronic end-stage kidney disease at any age 1.
Abstract Background and Aims Myeloproliferative neoplasms (MPN) are chronic blood disorders defined by an overproduction of clonal, differentiated hematopoietic cells. A high prevalence kidney disease (CKD) is described in patients with MPN. The glomerular histological pattern MPN-related disease, glomerulopathy (MPN-RG), may not account for the entirety CKD risk this population, as it appears to be rare has mostly been reported myelofibrosis. inflammatory prothrombotic state clonal cells...
T-helper 17 (Th17) cell differentiation and downstream interleukin-17 (IL-17) production signaling is critical for neutrophil granulocyte recruitment activation subsequent host defense against Candida Staphylococcus1. This was highlighted by the description of specific defects this pathway, such as autosomal recessive IL17RA or dominant IL17F deficiencies, in patients with chronic mucocutaneous candidiasis staphylococcal skin disease2,3. Of interest, kidney, IL-17 also plays a significant...
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Summary Dopamine (DA) neurons of the ventral tegmental area (VTA) integrate cholinergic inputs to regulate key functions such as motivation and goal-directed behaviors. Yet temporal dynamic range mechanism action acetylcholine (ACh) on modulation VTA circuits reward-related behaviors are not known. Here we used a chemical-genetic approach for rapid precise optical manipulation nicotinic neurotransmission in vivo . We provide direct evidence that ACh tone fine-tunes firing properties DA...