A5006354813- Genomics and Rare Diseases
- Galectins and Cancer Biology
- Glycosylation and Glycoproteins Research
- Monoclonal and Polyclonal Antibodies Research
- BRCA gene mutations in cancer
- Genetic Associations and Epidemiology
- Behavioral Health and Interventions
- Personality Traits and Psychology
- DNA Repair Mechanisms
- Youth Development and Social Support
- Genomic variations and chromosomal abnormalities
- Mycobacterium research and diagnosis
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Genetic and phenotypic traits in livestock
- Bioinformatics and Genomic Networks
- Thyroid and Parathyroid Surgery
- Adventure Sports and Sensation Seeking
- Cardiac, Anesthesia and Surgical Outcomes
- Chromosomal and Genetic Variations
- Digestive system and related health
- Thyroid Cancer Diagnosis and Treatment
- CRISPR and Genetic Engineering
- Natural Language Processing Techniques
University of Tartu
2019-2021
Effector functions of immunoglobulin G (IgG) are regulated by the composition a glycan moiety, thus affecting activity immune system. Aberrant glycosylation IgG has been observed in many diseases, but little is understood about underlying mechanisms. We performed genome-wide association study N-glycosylation (
Abstract Genotype imputation has become a standard procedure prior genome-wide association studies (GWASs). For common and low-frequency variants, genotype can be performed sufficiently accurately with publicly available ethnically heterogeneous reference datasets like 1000 Genomes Project (1000G) Haplotype Reference Consortium panels. However, the of rare variants been shown to significantly more accurate when matched panel is used. Even more, greater genetic similarity between target...
This study mapped the personality and genetics of risky excitement-seekers focusing on skydiving behavior. We compared 298 skydivers to demographically matched controls across NEO Personality Inventory-3 domains, facets, 240 items. The most significant item-level effects were aggregated into a poly-item score skydiving-associated markers (Study 1), where higher scores describe individuals who enjoy situations but have no self-control issues. marker was associated with greater physical...
ABSTRACT Genotype-first approach allows to systematically identify carriers of pathogenic variants in BRCA1 / 2 genes conferring a high risk familial breast and ovarian cancer. Participants the Estonian biobank have expressed support for disclosure clinically significant findings. With an cohort, we applied genotype-first approach, contacted offered return results with genetic counseling. We evaluated participants’ responses clinical utility reporting actionable Twenty-two 40 17 responded...
This study mapped the personality and genetics of risky excitement-seekers focusing on skydiving behavior. We compared 298 skydivers to demographically matched controls across NEO Personality Inventory-3 domains, facets 240 items. The most significant item-level effects were aggregated into a poly-item score skydiving-associated markers (SPM; Study 1), where higher scores describe individuals who enjoy situations but have no self-control issues. SPM was associated with greater physical...