The development of cancer nanotherapeutics has attracted great interest in the recent decade. Cancer have overcome several limitations conventional therapies, such as nonspecific biodistribution, poor water solubility, and limited bioavailability. Nanoparticles with tuned size surface characteristics are key components nanotherapeutics, designed to passively or actively deliver anti-cancer drugs tumor cells. We provide an overview nanoparticle-based drug delivery methods therapies based on...

Bifunctional electrocatalysts with excellent activity and durability are highly desirable for alkaline overall water splitting, yet remain a significant challenge. In this contribution, palm-like Mo

Abstract Composite polymer solid electrolytes (CPEs), possessing good rigid flexible, are expected to be used in solid‐state lithium‐metal batteries. The integration of fillers into matrices emerges as a dominant strategy improve Li + transport and form ‐conducting electrode–electrolyte interface. However, challenges arise traditional fillers: 1) inorganic fillers, characterized by high interfacial energy, induce agglomeration; 2) organic with elevated crystallinity, impede intrinsic ionic...

This study is devoted to developing amphiphilic block polymers based on phenylborate ester, which can self-assemble form nanoparticles, as a glucose-sensitive drug carrier. Poly(ethylene glycol)-block-poly[(2-phenylboronic esters-1,3-dioxane-5-ethyl) methylacrylate] (MPEG5000-block-PBDEMA) was fabricated with MPEG5000-Br macroinitiator via atom transfer radical polymerization (ATRP). Using the solvent evaporation method, these disperse in aqueous milieu into micellar aggregates spherical...

Efficient therapeutic strategies that concurrently target both Aβ aggregation and oxidative stress in the Alzheimer's disease (AD) microenvironment emerge as a cutting-edge tool to combat intricate pathogenesis of AD. Here, multivalent nanobody conjugate with rigid, reactive oxygen species (ROS) scavenging scaffold is developed achieve simultaneous amyloidogenesis mitigation, ROS elimination, plaque clearance. Grafting segment (33-GLMVGGVVIA-42) into third complementary-determining region...

Accurate diagnosis and timely therapeutic intervention of inflammatory bowel disease (IBD) is essential in preventing the progression disease, although it still represents an insurmountable challenge. Here we report design bacterial-flagella-inspired polydiiododiacetylene (PIDA) nanofibers its performance targeted computed tomography (CT) imaging on-demand IBD. With a morphology mimicking bacterial flagella, PIDA attach on mucus layer gastrointestinal (GI) tract after oral administration,...

Diabetic wounds are usually entangled in a disorganized and self-perpetuating microenvironment accompanied by prolonged delay tissue repair. Sustained coordinated regulation regeneration key to the healing process of diabetic wounds, yet they continue pose formidable challenge. Here we report rational double-layered dressing design based on chitosan degradable conjugated polymer polydiacetylene, poly(deca-4,6-diynedioic acid) (PDDA), that can meet this intricate requirement. With an...

Controllably tuned infrared emissivity has attracted great interest for potential application in adaptive thermal camouflage. In this work, we report a flexible multilayer graphene based device on porous polyethylene membrane, where the could be by ionic liquid intercalation. The Fermi level of surface shifts to high energy through intercalation, which blocks electronic transition below level. Thus, optical absorptivity/emissivity controlled Experimentally, was found from 0.57 0.41 after...

Composite polymer electrolytes (CPEs) containing Li6.4La3Zr1.4Ta0.6O12 (LLZTO) is widely regarded as leading candidate for high energy density solid-state lithium-metal batteries due to its exceptional ionic conductivity and environmental stability. However, Li2CO3 LiOH layers at LLZTO surface greatly hinder Li+ transport between LLZTO-polymer the electrode-electrolyte interface. Herein, of boronized obtain functionalized LLZTO, conversion mechanism clarified. By dissolving crystal structure...

Silicosis is a pulmonary disease characterized by inflammation and progressive fibrosis. Previous studies have shown that polydatin (PD) has potential biological activity in key signaling pathways regulating apoptosis. To investigate the effect of PD on rats with silicosis, this study used network pharmacology molecular docking methods to determine target treatment for silicosis. The therapeutic silicosis was confirmed measuring lung injury score, hydroxyproline content, mRNA expression...

Abstract α‐Synuclein (α‐Syn) amyloidogenesis is considered a promising diagnostic marker and therapeutic target for Parkinson's disease (PD). Simultaneously visualizing mitigating α‐Syn are essential future PD theranostics, yet they continue to pose an insurmountable challenge. This study have herein developed nanobody‐decorated polydiacetylene approach straightforward solution. Grafting α‐Syn61‐95 segment into the third complementary determining region of parent nanobody generates...

Abstract Aims GZR18, a novel long‐acting GLP‐1 receptor agonist, has demonstrated substantial metabolic improvements in diabetic and obese animal models. The present studies aimed to evaluate the safety, tolerability, pharmacokinetics (PK) pharmacodynamics (PD) of ascending dose GZR18 healthy American Chinese subjects. Materials Methods In these phases 1, randomized, double‐blind, placebo‐controlled, sequential, dose‐escalation US studies, adults with similar age were enrolled once‐weekly...

Abstract Li‐O 2 batteries are promising energy storage devices with ultra‐high theoretical density. However, in practice they show severe capacity fading and limited cycle life, meaning that more suitable electrolytes urgently needed. Here, solvents combined high donor number low number, a Li salt to produce new local strong solvation effect electrolyte. High discharge good cycling performance achieved when the optimized electrolyte is used battery. The inhibits side reactions within battery...

Silicon (Si)-based materials have been considered as one of the most promising anodes for development high-energy-density lithium-ion batteries (LIBs). However, poor interfacial stability and structural degradation are critical challenges successful application Si-based in LIBs. Herein, use a novel fluorinated carbonate (trifluoropropylene carbonate, TFPC) with high reduction potential rapid film-forming ability an electrolyte cosolvent is reported, which overcomes deterioration electrode...

Open AccessCCS ChemistryCOMMUNICATIONS30 Jun 2024Three-Dimensional Interlocked Crystalline Frameworks for Photocatalytic CO2 Conversion Wei Zhou, Mengqian Xu, Xiao Wang, Xu Fang, Xi Chen, Qingkun Kong, Ruiling Zhang, Lei Sun, Liyuan Zhao, Xing Lu, Wei-Qiao Deng and Chengcheng Liu Zhou , Wang Fang Chen Kong Zhang Sun Zhao Lu https://doi.org/10.31635/ccschem.024.202404171 SectionsSupplemental MaterialAboutPDF ToolsAdd to favoritesDownload CitationsTrack Citations ShareFacebookTwitterLinked...

Zearalenone (ZEN) contamination in cereals poses a serious threat to human and animal health, yet existing rapid test methods still suffer from poor stability low sensitivity. The studied sensor reduces inspection time while enabling applications for on-site grain inspection. Specifically, ZEN detector that can sensitively detect content grains was developed. Ion implantation is an effective method modifying screen-printed electrodes (SPEs). Gold nanoparticles (AuNPs; 5-10 nm) were uniformly...

Amyloid fibril assembly is associated with many human disorders, and to approach an inhibitor of amyloid formation that effective at ultralow stoichiometric concentrations remains a big challenge. Taking islet polypeptide (IAPP) as model system, we demonstrate here conjugating rationally designed sequence-specific nanobody M1 gold nanoparticles (AuNPs) can significantly enhance the inhibition potency M1, leading complete IAPP fibrillation very low M1:IAPP molar ratios. Thioflavin T kinetics...

Solar evaporation is an economically feasible method for desalination and distillation.

Li–O2 batteries are believed to be practical energy storage devices for electric vehicles due their ultrahigh theoretical specific energy. The major challenges the poor interface stability of electrode/electrolyte caused by degradation electrolyte and cathode formation lithium dendrites, which drain battery life. Meanwhile, high temperatures will accelerate reaction lead rapid death batteries. Herein, we present a multifunctional quasi-solid-state based on metal–organic framework (MOF) an...