A5083956940- Particle accelerators and beam dynamics
- Particle Accelerators and Free-Electron Lasers
- Superconducting Materials and Applications
- Gyrotron and Vacuum Electronics Research
- Bone and Dental Protein Studies
- Magnetic confinement fusion research
- Liver physiology and pathology
- dental development and anomalies
- Cancer Cells and Metastasis
- Liver Disease Diagnosis and Treatment
- Particle Detector Development and Performance
- Mesenchymal stem cell research
- Cancer, Hypoxia, and Metabolism
- Digestive system and related health
- Cancer Research and Treatments
- Spacecraft and Cryogenic Technologies
- Chemical Reactions and Isotopes
- Earthquake Detection and Analysis
- AI in cancer detection
- Circular RNAs in diseases
- Heat Transfer and Optimization
- Embedded Systems and FPGA Design
- Cytokine Signaling Pathways and Interactions
- Diabetes and associated disorders
- earthquake and tectonic studies
Institute of High Energy Physics
2015-2024
Chinese Academy of Sciences
2012-2024
University of Chinese Academy of Sciences
2015-2024
East China University of Technology
2024
Taiyuan University of Technology
2024
Ningxia Medical University
2021
Loyola University Medical Center
2012-2016
Loyola University Chicago
2011-2016
Duke University
2006-2011
Duke Medical Center
2004-2011
<h3>Background</h3> Chronic liver injury triggers a progenitor cell repair response, and fibrosis occurs when becomes deregulated. Previously, we reported that reactivation of the hedgehog pathway promotes fibrogenic repair. Osteopontin (OPN) is hedgehog-target, cytokine highly upregulated in fibrotic tissues, regulates stem-cell fate. Thus, hypothesised OPN may modulate thereby, outcomes. We further evaluated impact OPN-neutralisation on murine fibrosis. <h3>Methods</h3> Liver progenitors...
Osteopontin (OPN) promotes hepatic fibrosis, and developing therapies targeting OPN expression in settings of injury holds promise. The polyphenol epigallocatechin-3-gallate (EGCG), found high concentrations green tea, downregulates through mRNA degradation, but the mechanism is unknown. Previous work has shown that microRNAs can decrease levels, other studies have EGCG modulates multiple microRNAs. In our study, we first demonstrated induces stellate cells to transform into an activated...
Recently, heat treatment in the range of 250 °C–500 °C has been attempted with aim improving quality factor (Q) superconducting radio-frequency (SRF) cavities worldwide. Herein, medium-temperature (mid-T) furnace baking experiments were conducted at Institute High Energy Physics to obtain higher Q values. First, 1.3 GHz 1-cell received mid-T different temperatures, resulting not only improvement but also an anti-Q-slope behavior. Furthermore, was applied six 9-cell cavities, all which...
A low-frequency superconducting cavity is needed in main accelerators for storage ring light sources with ultralow emittance. compact 166.6 MHz proof-of-principle was designed adopting a quarter-wave β = 1 geometry High Energy Photon Source (HEPS). It 6 GeV diffraction-limited synchrotron source currently being developed at the Institute of Physics. The exceedingly size yet possessing low resonant frequency. nearest higher order mode largely separated from fundamental, making an attractive...
The world’s first 1.3 GHz cryomodule containing eight 9-cell superconducting radio-frequency (rf) cavities treated by medium-temperature furnace baking (mid-T bake) was developed at the Institute of High Energy Physics, Chinese Academy Sciences. in achieved an unprecedented high average intrinsic quality factor (<a:math xmlns:a="http://www.w3.org/1998/Math/MathML" display="inline"><a:mrow><a:msub><a:mi>Q</a:mi><a:mn>0</a:mn></a:msub></a:mrow></a:math>) <c:math...
Medium-temperature (mid-T) furnace baking was conducted at 650 MHz superconducting radio-frequency (SRF) cavity for circular electron positron collider (CEPC), which enhanced the unloaded quality factor (Q0) significantly. In vertical test (2.0 K), Q0 of reached 6.4 × 1010 30 MV/m, is remarkably high this unexplored frequency. Additionally, quenched 31.2 MV/m finally. There no anti-Q-slope behavior after mid-T baking, characteristic 1.3 GHz cavities. The microwave surface resistance (RS)...
A superconducting 166.6 MHz quarter-wave beta=1 cavity was recently proposed for the High Energy Photon Source (HEPS), a 6 GeV kilometer-scale light source. Four cavities will be used main acceleration in newly planned on-axis beam injection scheme realized by double-frequency RF system. The fundamental frequency, MHz, dictated fast kicker technology and preference of using 499.8 SC as third harmonic. Each operated at 4.2 K providing 1.2 MV accelerating voltage 150 kW power to electron beam....
The storage ring of the high energy photon source will be driven by five 166.6 MHz β = 1 quarter-wave superconducting cavities operating at 4 K. A higher-order-mode-damped cavity was designed with excellent rf and mechanical properties based on successful development proof-of-principle cavity. design dressed focused addressing stress safety throughout processes, tunability, frequency detuning due to pressure fluctuation, Lorentz force, among other factors. new liquid helium vessel along a...
CEPC is a 100-km double-ring circular electron–positron collider operating at 90–240 GeV center-of-mass energy of Z-pole, WW-pair production threshold and Higgs resonance. The conceptual design report (CDR) has been published as an important step to move the project forward. superconducting RF (SRF) system one most challenging accelerator systems due wide range beam current. In this paper, layout, parameters configuration for ring will be introduced. Issues cavity interactions including...
Superconducting β=1 quarter-wave geometry of 166.6 MHz has been proposed as main accelerating cavities for the high-energy photon source (HEPS) storage ring. HEPS is a 6-GeV kilometer-scale synchrotron light promising ultralow emittance currently being constructed in Beijing. A proof-of-principle cavity previously in-house developed and vertical-tested achieving excellent cryogenic performances. helium jacket was subsequently designed adopting simple structure an integrated magnetic field...