A5044871495- Autophagy in Disease and Therapy
- Phytochemistry and Biological Activities
- Adipose Tissue and Metabolism
- Sirtuins and Resveratrol in Medicine
- Cardiac Ischemia and Reperfusion
- Pancreatitis Pathology and Treatment
- Phytochemistry and biological activity of medicinal plants
- Phytochemical Studies and Bioactivities
- Force Microscopy Techniques and Applications
- Research on Leishmaniasis Studies
- Inflammatory Bowel Disease
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Nuclear Structure and Function
- Medicinal Plants and Bioactive Compounds
- Calcium signaling and nucleotide metabolism
- Lipid metabolism and disorders
- Mechanical Circulatory Support Devices
- Blood Coagulation and Thrombosis Mechanisms
- Cell death mechanisms and regulation
- Cytokine Signaling Pathways and Interactions
- Inflammasome and immune disorders
- Gut microbiota and health
- Cellular Mechanics and Interactions
- Lung Cancer Treatments and Mutations
- Epigenetics and DNA Methylation
Harbin Medical University
2012-2022
Fourth Affiliated Hospital of Harbin Medical University
2016-2022
University at Buffalo, State University of New York
2016
China Medical University
2011-2013
First Hospital of China Medical University
2011
Picroside II, from the herb Picrorhiza scrophulariiflora Pennell, has antioxidant and anti-inflammatory activities. However, its function on severe acute pancreatitis (SAP) molecular mechanism remains unknown. The effects of picroside II SAP induced by cerulean were investigated. rats treated with (25 mg/kg). severity was evaluated using biochemical histological analyses. Pancreatic cancer cell PANC-1 transfected ptfLC3 (an indicator autophagic activity), pcDNA3.1-NF-κB (nuclear factor kappa...
Picroside II, an iridoid glucoside found in the root of Picrorhiza scrophulariiflora Pennell (Scrophulariaceae), has been demonstrated to reduce apoptosis neuronal cells and other cell types. However, whether picroside II a protective effect against cardiomyocyte is poorly understood. In present study, we investigated cardioprotective role underlying mechanisms hypoxia/reoxygenation-induced apoptosis. The pretreatment with markedly attenuated damage dose-dependently, which was evident by...
Panax ginseng is a well-known medicinal herb that widely used in traditional Chinese medicine for treating various diseases. Ginsenoside Rg3 (Rg3) thought to be one of the most important active ingredients ginseng. However, molecular mechanism underlying beneficial effects has been elusive.In mouse heart injury model induced by isoproterenol (ISO), we brain natriuretic peptide (BNP), lactate dehydrogenase (LDH) and caspase-3 ELISA kits test myocardium injury. To whether protects myocardial...
Hydrostatin-SN1 (peptide sequence, DEQHLETELHTLTSVLTANGFQ), a kind of peptides extracted from snake venom, has been reported to have anti-inflammatory effect, but its truncated mutant hydrostatin-SN10 DEQHLETELH) on pancreatitis-induced acute lung injury not well documented. Interleukin- (IL-) 6-induced Janus Kinase 2/Signal Transducer and Activator Transcription 3 (JAK2/STAT3) pathway is involved with inflammatory oxidative stress activities may be associated the pathogenesis injury,...
The impairment of microcirculation is associated with the unfavorable outcome for extracorporeal membrane oxygenation (ECMO) patients. Studies revealed that pulsatile modification improves hemodynamics and attenuates inflammation during ECMO support. However, whether flow pattern impacts endothelial integrity rarely documented. objective this work was to explore how pulsatility affects ECMO. Canine animal models cardiac arrest were supported by ECMO, i-Cor system used generate nonpulsatile...
Picroside II, an iridoid glucoside found in the root of Picrorhiza scrophulariiflora Pennell (Scrophulariaceae), has been demonstrated to possess potent antioxidant activity. However, whether picroside II a protective effect against hypoxia/reoxygenation (H/R)-induced cardiomyocyte injury is poorly understood.To explore cardioprotective role oxidative stress induced by H/R neonatal rat cardiacmyocytes.The viability and cellular damage cardiomyocytes were assessed...
DNMT3B polymorphisms are associated with the susceptibility of lung cancer. -2437T>A is a novel polymorphism, and its influence on risk cancer in Chinese was investigated this study. In addition, effect -149C>T polymorphism also explored.Genotyping subjects were performed by PCR-RFLP. Haplotype frequencies estimated estimating haplotype software. Adjusted odds ratios (ORs) 95% confidence intervals (CIs) calculated unconditional logistic regression analysis.Neither two correlated (-149C>T:...
Endothelial dysfunction plays a central role in the pathogenesis of diabetic vascular complications. 2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucoside (TSG), an active component extracted from roots Polygonum multiflorum Thunb, has been shown to have strong antioxidant and antiapoptotic activities. In present study, we investigated protective effect TSG on apoptosis induced by high glucose human umbilical vein endothelial cells (HUVECs) possible mechanisms. Our data demonstrated that...
<h3>Objectives</h3> Picroside II, an iridoid glucoside found in the root of Picrorhiza scrophulariiflora Pennell (Scrophulariaceae), has been demonstrated to reduce apoptosis neuronal cells and other cell types. However, whether picroside II a protective effect against cardiomyocyte is poorly understood. In present study, we investigated cardioprotective role underlying mechanisms hypoxia/reoxy-genation-induced apoptosis. The pretreatment with markedly attenuated...