Paul Heinrich
A5067260332- Gut microbiota and health
- Mycobacterium research and diagnosis
- Hematopoietic Stem Cell Transplantation
- Immune Cell Function and Interaction
- Neutropenia and Cancer Infections
- Clostridium difficile and Clostridium perfringens research
- Clinical Nutrition and Gastroenterology
- Cancer Immunotherapy and Biomarkers
- Metabolomics and Mass Spectrometry Studies
Leibniz Association
2023-2024
University of Regensburg
2023-2024
University Hospital Regensburg
2022-2024
Leibniz Institute for Immunotherapy
2023
Inter-individual differences in response to immune checkpoint inhibitors (ICI) remain a major challenge cancer treatment. The composition of the gut microbiome has been associated with differential ICI outcome, but underlying molecular mechanisms unclear, and therapeutic modulation challenging.
Summary Intestinal stem cells (ISC) promote tissue repair after genotoxic or immune-mediated injury. However, ISCs are particularly sensitive to various stressors and primary targets of overwhelming immune responses such as interferon-γ (IFNγ)-mediated killing. In mouse models gut damage biopsies from patients having undergone allo-hematopoietic cell transplantation, we observed IFNy expression by intestinal T reg cells. leverage combined IFNγ interleukin 10 (IL-10) stimulation nurture the...