A5086857428- Gut microbiota and health
- Mycobacterium research and diagnosis
- Hematopoietic Stem Cell Transplantation
- Neutropenia and Cancer Infections
- Pancreatic and Hepatic Oncology Research
- Clostridium difficile and Clostridium perfringens research
- Immune Cell Function and Interaction
- Metabolomics and Mass Spectrometry Studies
- Oral health in cancer treatment
- Gastrointestinal Tumor Research and Treatment
- Acute Myeloid Leukemia Research
- Gastric Cancer Management and Outcomes
Technical University of Munich
2022-2024
Klinikum rechts der Isar
2022-2024
LMU Klinikum
2023
Paclitaxel in combination with ramucirumab is the standard of care second-line therapy gastro-esophageal adenocarcinoma (GEA). As number taxane pretreated patients perioperative or first-line setting increasing, it unknown whether these benefit from re-applying a using paclitaxel and ramucirumab. Furthermore, rates neurotoxicity FOLFOX FLOT range 30%-70%, making taxane-containing less suitable to meaningful portion patients. This patient group likely taxane-free chemotherapy regimen, such as...
Reduced intensity conditioning (RIC) and reduced toxicity (RTC) regimens enable allogeneic hematopoietic stem cell transplantation (alloSCT) to more patients due reduction in transplant-related mortality (TRM). The with fludarabine treosulfan (Flu/Treo) or fludarabine, amsacrine, cytarabine (FLAMSA)-RIC have shown their efficacy tolerability various malignancies. So far, no prospective study comparing the two is available. Two studies compared retrospectively, which both provided similar...
Abstract The intestinal bacteriome directly affects outcome in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-SCT). Besides bacteria, fungal and viral communities as well microbiota-derived metabolites play a role. Yet, it is still unclear how dynamic shifts these three contribute to (1) clinical of allo-SCT patients, (2) production (3) they are affected by microbiome modulation via antibiotics or fecal microbiota (FMT). Here, we performed prospective,...