A5027890813- Chronic Lymphocytic Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- Origins and Evolution of Life
- Neonatal Respiratory Health Research
- Mechanical Circulatory Support Devices
- Congenital Diaphragmatic Hernia Studies
- Microbial Metabolic Engineering and Bioproduction
- Extraction and Separation Processes
- Advancements in Battery Materials
- Metabolomics and Mass Spectrometry Studies
- Lymphoma Diagnosis and Treatment
- Advanced Breast Cancer Therapies
- Hematopoietic Stem Cell Transplantation
- Mass Spectrometry Techniques and Applications
- Cardiac Structural Anomalies and Repair
- Cardiovascular Conditions and Treatments
- Advanced Battery Materials and Technologies
- Trauma Management and Diagnosis
- Aortic Disease and Treatment Approaches
- Transplantation: Methods and Outcomes
- Blood disorders and treatments
- Cardiac Valve Diseases and Treatments
- Infectious Aortic and Vascular Conditions
University of Chicago
2022-2025
Yamanashi Prefectural Central Hospital
2011-2024
National Hospital Organization Saitama Hospital
2021
Tokyo Dental College
2021
Sasaki Institute
2021
National Hospital Organization
2021
Shoei Chemical (Japan)
2013-2018
Shoei Junior College
2013-2018
University of Yamanashi
2003-2017
Mitsui (Japan)
2015
A novel ionization platform for matrix-free laser desorption/ionization-mass spectrometry (LDI-MS) was developed using self-assembled germanium nanodots (GeNDs) of uniform size (∼150−200-nm width and ∼50-nm height) grown on a silicon wafer produced by molecular beam epitaxy. The performance LDI-MS GeNDs (GeND-MS) investigated through measurements broad range analytes, including peptides, proteins, synthetic oligomers, polymer additives. Mass spectra tryptic digests were clearly observed even...
In patent ductus arteriosus (PDA) in preterm infants, the relationship between treatment timing and long-term developmental prognosis remains unclear. The purpose of this study was to clarify age days when closure occurred development. Preterm infants with a birth weight less than 1500 g who were admitted our NICU over period 9 years (2011–2019) diagnosed PDA included. A new version K-type test for corrected ages 1.5 3 used as an index duration evaluated using Pearson’s correlation...
Prognosis of childhood acute lymphoblastic leukemia (ALL) has been dramatically improved. However, prognosis the cases refractory to primary therapy is still poor. Recent phase 2 study on efficacy combination chemotherapy with bortezomib (BTZ), a proteasome inhibitor, for ALL demonstrated favorable clinical outcomes. septic death was observed in over 10% patients, indicating necessity biomarkers that could predict BTZ sensitivity. We investigated vitro sensitivity large panel cell lines...
The COVID-19 pandemic, spanning from early 2020 to late 2022, posed unprecedented challenges for global public health. However, it also spurred innovative approaches pandemic management, notably the development of pathogen detection in wastewater. It was successfully demonstrated that wastewater analysis can not only reflect ongoing infections but serve as an indicator disease prevalence within communities. Recognizing value longitudinal analyses various pathogens, we identified need...
Article Late-Onset Circulatory Dysfunction After Thyroid Hormone Treatment in an Extremely Low Birth Weight Infant was published on February 1, 2010 the journal Journal of Pediatric Endocrinology and Metabolism (volume 23, issue 1-2).
S-phase progression of the cell cycle is accelerated in tumors through various genetic abnormalities, and, thus, pharmacologic inhibition altered cell-cycle would be an effective strategy to control tumors. In current study, we analyzed antileukemic activity three available small molecules targeting CDK4/CDK6 against lymphoid crisis chronic myeloid leukemia (CML-LC) and Philadelphia chromosome-positive acute lymphoblastic (Ph(+) ALL), found that all showed specific activities leukemic lines...
Abstract Fms-like tyrosine kinase 3 (FLT3) is highly expressed in acute lymphoblastic leukemia with the mixed-lineage (MLL) gene rearrangement refractory to chemotherapy. We examined biological effect of FLT3-ligand (FL) on 18 B-precursor leukemic cell lines variable karyotypic abnormalities, and found that nine MLL-rearranged wild-type FLT3, contrast other lines, are significantly inhibited their proliferation a dose-dependent manner by FL. This inhibition was due induction G0-G1 arrest. A...
In surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS), a chemical background signal, arising from organic contaminants such as plasticizers, is frequently observed mainly under m/z ca. 600, which impairs the advantages of matrix-free approach. Silver salts, are used for cationization aromatic compounds, also difficult to remove completely after measurements. this study, surface cleaning techniques in semiconductor processing were clean our developed silicon-based SALDI...
Novel hybrid Li2MnSiO4 nanoparticles with carbon have been in-site synthesized by spray pyrolysis of a precursor solution, exhibiting stable cycling performance high discharge capacity about 200 mAh/g. The TEM observation showed the unique morphology particles only 10–20 nm in size surrounded phase, which can contribute to short diffusion path Li+ ions and easy relaxation structural distortion through delithiation/lithiation. XRD, XANES, EXAFS studies charged/discharged structures revealed...
The purpose of this study was to evaluate the effects once daily (OD) or every 48 hours (every-48-h) administration amikacin (AMK) on renal function and ototoxicity in neonates. We investigated frequency nephrotoxicity neonates who received AMK OD every-48-h from April 2015 March 2021 underwent dose evaluation by therapeutic drug monitoring (TDM). In addition, relationships among birth weight, gestational age, peak trough values, total duration administration, were examined separately for...
The β peptide (113-125), derived from a conserved sequence of the subunit integrins, was synthesized to investigate its adhesive properties matrix proteins and effects on cell adhesion immobilized fibronectin. In this study, we observed that biotinylated able bind efficiently fibronectin, fibrinogen, collagen Type I vitronectin with different degrees affinity. It also demonstrated fibronectin or fibrinogen could coated peptide. This kind binding, which might be non-covalent linkage,...
Abstract Background: Fetal goitrous hypothyroidism is mainly caused by maternal treatment of Graves’ disease. goiter sometimes compresses the trachea and esophagus may cause polyhydramnios, preterm labor, complications labor delivery, neonatal respiratory disorder. Case presentation: We report a case fetal in which mother had disease, was treated with propylthiouracil. Intra-amniotic levothyroxine (L-T Conclusions: Previous reports on that intra-amniotic L-T
We reviewed 50 patients with Marfan syndrome who underwent surgery for aortic root pathologies comprising a aneurysm without (n = 25; group A) and B) dissection. Aortic repair included Bentall 37) valve-sparing 13) procedures. Hospital mortality was 4.0%. Twenty-two required 36 repeat surgeries on the distal aorta. The main indication re-intervention dilation of false lumen. In A, aorta stable up to 7 years, but new dissection developed in 5 (33.3%) 15 were followed >7 years after repair....